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Peroxisomal disorders

Lee SY

  • KMID: 2168072
  • Hanyang Med Rev.
  • 2005 Aug;25(3):42-48.
Peroxisomes are subcellular organells catalyzing a number of important functions in cellular metabolism. Their functions are mostly related to lipid metabolism. Genetic disorders of peroxisomes are divided into 2 categories:...
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Role of Peroxisome Proloferator-activated Receptor in the Lipid Metabolism

Kim YS

  • KMID: 2331102
  • J Korean Soc Endocrinol.
  • 1998 Sep;13(3):303-307.
No abstract available.
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Association Study of the Peroxisome Proliferators-Activated Receptor gamma2 Pro12Ala Polymorphism with Diabetic Nephropathy

Kwon MJ, Park JH

No abstract available.
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Zellweger Syndrome : First Confirmed Neonatal Case in Korea

Kim SS, An YH, Chang YS, Jin DK, Park WS, Lee MH, Kim JW, Yoon HK, Kim BK

  • KMID: 1606284
  • J Korean Pediatr Soc.
  • 2001 Jun;44(6):694-698.
We describe below a case of Zellweger syndrome case with facial dysmorphism, profound hypotonia, and hepatomegaly. He died at the age of 2 months. Zellweger syndrome is a disease marked...
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Current Understanding of Peroxisome Proliferator-Activated Receptor delta

Ham J, Won DH, Kang H

  • KMID: 2200302
  • J Korean Soc Endocrinol.
  • 2003 Jun;18(3):239-249.
No abstract available.
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Therapeutic Target for Regulating IL-17 Expression in Asthma: Phosphoinositide 3-Kinase and Peroxisome Proliferator-Activated Receptor Activator gamma

  • KMID: 2299558
  • Korean J Asthma Allergy Clin Immunol.
  • 2009 Sep;29(3):157-163.
No abstract available.
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Novel ABCD1 Gene Mutation in a Korean Patient with X-Linked Adrenoleukodystrophy Presenting with Addison's Disease

Cho YK, Lee SY, Kim SW

X-linked adrenoleukodystrophy (X-ALD) occurs due to mutations in the ABCD1 gene that encodes the peroxisomal membrane protein peroxisomal transporter ATP-binding cassette sub-family D member 1 (ABCD1). Degradation of very long-chain...
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Colorectal Cancer Expression of Peroxisome Proliferator-Activated Receptor gamma Is Associated with Good Prognosis

Lee BI

  • KMID: 2174123
  • Intest Res.
  • 2009 Jun;7(1):71-72.
No abstract available.
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Abnormal Prenatal Sonographic findings in Two Cases of Zellweger Syndrome

Park SJ, Oh JY, Jung E, Kim SK, Shim JY, Won HS, Lee PR, Kim A

  • KMID: 1876152
  • Korean J Perinatol.
  • 2005 Mar;16(1):54-59.
Zellweger syndrome is a lethal autosomal recessive disorder characterized by neonatal hypotonia, neonatal seizure, psychomotor retardation, facial dysmorphism, and hepatomegaly. It is characterized by an absence or marked decrease of...
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Role of Reactive Oxygen Species in Hypothalamic Regulation of Energy Metabolism

Diano S

To understand the etiology of metabolic disorders, including obesity and type II diabetes, it is essential to gain better insight into how stored and available energy sources are monitored by...
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Peroxisome Proliferator-activated Receptors (PPARs) in Diabetic Nephropathy

Park CW

  • KMID: 1575476
  • J Korean Diabetes Assoc.
  • 2004 Jun;28(3):149-159.
No abstract available.
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Dehydroepiandrosterone-dependent induction of peroxisomal proliferation can be reduced by aspartyl esterification without attenuation of inhibitory bone loss in ovariectomy animal model

Kwak CS, Kang CM, Kang HS, Song KY, Lee MS, Seong SC, Park SC

The purpose of this study was to determine whether esterification of dehydroepiandrosterone with aspartate (DHEA-aspartate) could reduce peroxisomal proliferation induced by DHEA itself, without loss of antiosteoporotic activity. Female Sprague-Dawley...
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Functional Studies of Acyl-CoA Synthetase 4 in the Rat Liver

Jeong YH, Moon SJ, Kang MJ

  • KMID: 1618343
  • Korean J Nutr.
  • 2003 May;36(4):376-381.
Acyl-CoA synthetase 4 (ACS4) is an arachidonate-preferring enzyme abundant in steroidogenic tissues. We examined ACS4 in rat liver, which contains a variety of pathways that use acyl-CoAs, in order to...
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Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice

Park HS, Jang JE, Ko MS, Woo SH, Kim BJ, Kim HS, Park HS, Park IS, Koh EH, Lee KU

BACKGROUND: Non-alcoholic fatty liver disease is the most common form of chronic liver disease in industrialized countries. Recent studies have highlighted the association between peroxisomal dysfunction and hepatic steatosis. Peroxisomes...
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Effect of dietary protamine on lipid metabolism in rats

Hosomi R, Fukunaga K, Arai H, Kanda S, Nishiyama , Yoshida M

  • KMID: 2313481
  • Nutr Res Pract.
  • 2010 Dec;4(6):462-469.
Protamine has been widely used as a pharmaceutical product and natural food preservative. However, few studies have been conducted to assess the beneficial function of dietary protamine. This study examined...
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Endogenous catalase delays high-fat diet-induced liver injury in mice

Piao L, Choi J, Kwon G, Ha H

Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in parallel with worldwide epidemic of obesity. Reactive oxygen species (ROS) contributes to the development and progression of...
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Phthalate exposure and childhood obesity

Kim SH, Park MJ

Phthalates are commonly used as plasticizers and vehicles for cosmetic ingredients. Phthalate metabolites have documented biochemical activity including activating peroxisome proliferator-activated receptor and antiandrogenic effects, which may contribute to the...
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New and emerging drugs in type 2 diabetes

Park IB

  • KMID: 2256406
  • Korean J Med.
  • 2007 May;72(5):446-450.
Recent advances in understanding insulin secretion, action and signaling have led to the development of new pharmacological agents. Several new emerging drugs and drug classes for the management of diabetes...
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Peroxisome Proliferator Activated Receptor-delta (PPAR-delta)

Choi KM

The development of novel treatments for the metabolic syndrome is imminent for decreasing the prevalence of type 2 diabetes and cardiovascular disease. Peroxisome proliferator-activated receptors (PPARs) are members of the...
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Role of Peroxisome Proliferator-Activated Receptor alpha in Diabetic Nephropathy

Chung S, Park CW

With a developing worldwide epidemic of diabetes mellitus, the renal complications associated with diabetes have become a serious health concern. Primary therapy for treating diabetic nephropathy is a multifactorial process....
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