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A Comparative Analysis of Monofunctional Biosynthetic Peptidoglycan Transglycosylase (MBPT) from Pathogenic and Non-pathogenic Bacteria

Baker AT, Takahashi , Chandra SB

  • KMID: 2166479
  • Genomics Inform.
  • 2010 Jun;8(2):63-69.
Monofunctional biosynthetic peptidoglycan transglycosylase (MBPT) catalyzes the formation of the glycan chain in bacterial cell walls from peptidoglycan subunits: N-acetylglucosamine (NAG) and acetylmuramic acid (NAM). Bifunctional glycosyltransferases such as the...
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Texiobactin, a Potent Killer of Antibiotic Resistant Pathogens

Arooj M, Koh YS

Antibiotic resistance is a major global concern that primarily affects public health. Texiobactin is a newly discovered antibiotic produces by soil microbes isolated from natural environment. Drug is active against...
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Peptidoglycan Induces the Production of Interleukin-8 via Calcium Signaling in Human Gingival Epithelium

Son A, Shin DM, Hong JH

The etiology of periodontal disease is multifactorial. Exogenous stimuli such as bacterial pathogens can interact with toll-like receptors to activate intracellular calcium signaling in gingival epithelium and other tissues. The...
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The effects of bee venom pretreatment of an acupoint on inflammation and hyperalgesia induced by peptidoglycan

Park JT, Lee JY, Lee YB, Kang DY

BACKGROUND: Systemic injection of peptidoglycan (PGN) special polymers, which are the primary structural components of most bacterial cell walls, leads to acute inflammation and pain behavior. This study was conducted...
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Peptidoglycan Up-Regulates CXCL8 Expression via Multiple Pathways in Monocytes/Macrophages

Lee CW, Chung SW, Bae MJ, Song S, Kim SP, Kim K

Peptidoglycan (PG), the gram positive bacterial pathogen-associated molecular patterns (PAMP), is detected in a high proportion in macrophage-rich atheromatous regions, and expression of chemokine CXCL8, which triggers monocyte arrest on...
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Nucleotide-binding oligomerization domain 1 is dispensable for host immune responses against pulmonary infection of Acinetobacter baumannii in mice

Kang MJ, Choi JA, Choi JH, Jang AR, Park JY, Ahn JH, Lee TS, Kim DY, Park JH

Nucleotide-binding domain 1 (Nod1) is a cytosolic receptor that is responsible for the recognition of a bacterial peptidoglycan motif containing meso-diaminophimelic acid. In this study, we sought to identify the...
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Expression of Human beta Defensin-2 in HaCaT Cell by Lipoteichoic Acid and Peptidoglycan

Kim JE, Jeong MS, Kim MN, Hong CK, Ro BI, Seo SJ

  • KMID: 1605841
  • Korean J Dermatol.
  • 2004 Dec;42(12):1559-1565.
BACKGROUND: Defensin, a major family of antimicrobial peptides, is small cationic, cysteine rich peptides with wide range of antimicrobial activity against Gram negative and Gram positive bacteria, fungi, yeast, and...
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Overexpression, purification and truncation analysis of RmlC protein of Mycobacterium tuberculosis

Lee JS, Lee TY, Park JH, Kim JS, Lee TJ, Lee JY, Kim SK

  • KMID: 2146871
  • J Korean Soc Microbiol.
  • 2000 Aug;35(4):273-282.
dTDP-rhamnose provides L-rhamnose to the bridge-like structure between mycolyl arabinogalactan and peptidoglycan of the mycobacterial cell wall. dTDP-rhamnose is composed of glucose-1-phosphate and dTTP by four enzymes encoded by rmlA-D. To determine the...
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IL-17 and Toll-like Receptor 2 or Toll-like Receptor 4 Combined Engagement Upregulates RANKL and IL-6 in Human Rheumatoid Synovial Fibroblasts

Kim KW, Lee SH, Cho ML, Oh HJ, Woo YJ, Kim SH, Kim HR

OBJECTIVE: The aim of this study was to clarify whether stimulation of recombinant IL-17, TLR2 and TLR4 by their specific ligands induces the production of RANKL and IL-6 in the...
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Mitochondrial calcium uniporter inhibition attenuates mouse bone marrow-derived mast cell degranulation induced by beta-1,3-glucan

Cuong DV, Kim HK, Marquez J, Kim N, Ko KS, Rhee BD, Han J

Mast cells are primary mediators of allergic inflammation. Beta-1,3-glucan (BG) protects against infection and shock by activating immune cells. Activation of the BG receptor induces an increase in intracellular Ca2+,...
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Antibacterial effects of sodium tripolyphosphate against Porphyromonas species associated with periodontitis of companion animals

Lee JH, Moon JH, Ryu JI, Kang SW, Kwack KH, Lee JY

Porphyromonas species are closely associated with companion animal periodontitis which is one of the most common diseases in dogs and cats and leads to serious systemic diseases if left untreated....
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Helicobacter pylori Virulence Factors and Host Factors

Kang BK, Kim BW

Helicobacter pylori (H. pylori) is one of the most common human infection world-wide. However, only a limited proportion of the infected population developed gastrointestinal diseases such as peptic ulcer disease,...
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The Expression Pattern of Toll-like Receptor (TLR) and Cytokine Production to TLR Agonists in Human Retinal Pigment Epithelial Cells

Choi SJ, Lee KH, Park SJ, Park HS, Kim J, Kim SK, Park JY

Retinal pigment epithelium (RPE) constituting the outer blood-retina barrier plays an important role in ocular defense mechanism. Many studies reported that RPE participates in ongoing immune responses in the retina....
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Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells

Kim KH, Lee J, Han JH, Myung SC

PURPOSE: The present study aimed to determine the role played by beta-defensin 124 (DEFB124) in the innate immunity of prostate epithelial RWPE-1 cells during bacterial infection. MATERIALS AND METHODS: The expression...
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Expression of Toll-like Receptors, Pro-, and Anti-inflammatory Cytokines in Relation to Gut Microbiota in Irritable Bowel Syndrome: The Evidence for Its Micro-organic Basis

Shukla R, Ghoshal U, Ranjan P, Ghoshal UC

  • KMID: 2422853
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):628-642.
  • doi: 10.5056/jnm18130
BACKGROUND/AIMS: A Subset of patients with irritable bowel syndrome (IBS) may have mild inflammation due to immune activation. Toll-like receptors (TLRs) and cytokines may cause intestinal inflammation. We studied their...
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Modulation of Antimicrobial Peptide Human beta-defensin-3 by Toll-like Receptor Ligands in Vaginal Epithelial Cells

Lee SY, Kim HJ, Chang IH, Han JH, Kim KD, Moon YT, Myung SC

PURPOSE: Vaginal epithelial cells have always been exposed to various pathogens. However, this has not always caused clinical infection. In addition to a previously reported protection effect of the vagina,...
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Toll-like Receptors 2 and 4 and Their Mutations in Patients with Otitis Media and Middle Ear Effusion

Lee YC, Kim C, Shim JS, Byun JY, Park MS, Cha CI, Kim YI, Lee JW, Yeo SG

  • KMID: 2278727
  • Clin Exp Otorhinolaryngol.
  • 2008 Dec;1(4):189-195.
OBJECTIVES: Toll-like receptors (TLRs) detect microbial infections and they can directly induce innate host defense responses. TLR 2 has been shown to be primarily involved in the recognition of peptidoglycans...
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