- Trichostatin A-mediated upregulation of p21
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Yi T, Baek JH, Kim HJ, Choi MH, Seo SB, Ryoo HM, Kim GS, Woo KM
- KMID: 1094662
- Exp Mol Med.
- 2007 Apr;39(2):213-221.
Histone deacetylase inhibitors (HDIs), a new class of anti-cancer agents, have been reported to suppress formation of osteoclast precursors and their fusion into multinucleated cells. However, little is known about... -
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- B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis
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Choi Y, Kim JJ
- KMID: 1093611
- Exp Mol Med.
- 2003 Oct;35(5):385-392.
Host immune response has been considered as an important disease-modifying factor of periodontitis, however, which immune cell(s) or factor(s) are involved in the destruction of periodontium remains unclear. Previously, we... -
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- Involvement of the Ca2+ signaling pathway in osteoprotegerin inhibition of osteoclast differentiation and maturation
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Fu Y, Gu J, Wang Y, Yuan Y, Liu X, Bian J, Liu ZP
- KMID: 2164523
- J Vet Sci.
- 2015 Jun;16(2):151-156.
- doi: 10.4142/jvs.2015.16.2.151
The purpose of this study was to determine whether the Ca2+ signaling pathway is involved in the ability of osteoprotegerin (OPG) to inhibit osteoclast differentiation and maturation. RAW264.7 cells were... -
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- Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-alpha by inhibiting activation of NF-kappaB
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Kyung TW, Lee JE, Shin HH, Choi HS
- KMID: 1103588
- Exp Mol Med.
- 2008 Feb;40(1):52-58.
- doi: 10.3858/emm.2008.40.1.52
Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappaB ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its... -
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- Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species
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Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK
- KMID: 1025163
- Exp Mol Med.
- 2011 Nov;43(11):605-612.
- doi: 10.3858/emm.2011.43.11.067
Osteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen... -
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