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Tissue Engineered Vascularized Bone Formation Using in vivo Implanted Osteoblast-Polyglycolic acid Scaffold

Kim WS, Kim HK

Repair of skeletal defects with vascularized bone grafts has many advantages over non-vascularized free grafts, but the availability of these grafts is extremely limited. This study was designed to determine...
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The Effects of Recombinant Human BMP-7, Prepared from a COS-7 Expression System, on the Proliferation and Differentiation of Rat Newborn Calvarial Osteoblasts

Lee DH, Suh H, Han DW, Park BJ, Lee JW, Park JC

A family of proteins, the bone morphogenetic proteins (BMPs), which promote osteoblast differentiation and bone mineralization, have recently been identified. One, BMP-7, has shown the ability to induce cartilage and...
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High extracellular Ca2+ alone stimulates osteoclast formation but inhibits in the presence of other osteoclastogenic factors

Shin MM, Kim YH, Kim SN, Kim GS, Baek JH

  • KMID: 1094697
  • Exp Mol Med.
  • 2003 Jun;35(3):167-174.
High ambient Ca2+ at bone resorption sites have been implicated to play an important role in the regulation of bone remodeling. The present study was performed to clarify the mode...
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Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates

Lee YJ, Jeong JK, Seol JW, Xue M, Jackson C, Park SY

  • KMID: 2154228
  • Exp Mol Med.
  • 2013 Feb;45(2):e9.
Activated protein C (APC) is a cytoprotective anticoagulant that can promote cutaneous healing. We examined the effect of APC on viability and differentiation of the osteoblastic line, MG63, in the...
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MiR-17-5p modulates osteoblastic differentiation and cell proliferation by targeting SMAD7 in non-traumatic osteonecrosis

Jia J, Feng X, Xu W, Yang S, Zhang Q, Liu X, Feng Y, Dai Z

MicroRNAs (miRNAs) have recently been recognized to have a role in human orthopedic disorders. The objective of our study was to explore the expression profile and biological function of miRNA-17-5p...
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