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Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects

Lee JA, Ku Y, Rhyu IC, Chung CP, Park YJ

PURPOSE: Fibronectin (FN) has been shown to stimulate bone regeneration in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic...
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The biological effects of fibrin-binding synthetic oligopeptides derived from fibronectin on osteoblast-like cells

Kim YJ, Park YJ, Lee YM, Rhyu IC, Ku Y

PURPOSE: The aim of this study was to investigate the effects of synthetic fibronectin (FN) fragments, including fibrin binding sites from amino-terminal FN fragments containing type I repeats 1 to...
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General Features and Post-Exposure Prophylaxis of Rabies

Park JS, Han MG

Rabies is a representative zoonotic disease caused by rabies virus. The discriminative features of rabies are broad range of hosts including humans, a wide variety of incubation periods ranging from...
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Antihypertensive Angiotensin I-Converting Enzyme Inhibitory Activity and Antioxidant Activity of Vitis hybrid-Vitis coignetiae Red Wine Made with Saccharomyces cerevisiae

Jang JH, Lee JS

  • KMID: 2312631
  • Mycobiology.
  • 2011 Jun;39(2):137-139.
A Vitis hybrid-Vitis coignetiae red wine was vinified by fermentation of a mixture of a Vitis hybrid-Vitis coignetiae must with Saccharomyces cerevisiae KCTC 7904 at 25degrees C for 10 days....
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Acetaminophen Poisoning

Chung SP, Kim SH, Lee HS

  • KMID: 2203492
  • J Korean Soc Clin Toxicol.
  • 2008 Jun;6(1):1-8.
Acetaminophen (AAP) overdose can result in potentially serious hepatotoxicity. The ingested dose and time from ingestion to presentation are important prognostic factors. Toxic dose in adult is thought to be...
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The biologic effect of fibrin-binding synthetic oligopeptide on periodontal ligament cells

Lee JA, Ku Y, Park YJ, Koo KT, Kim TI, Seol YJ, Lee YM, Rhyu IC, Chung CP

PURPOSE: Fibronectin(FN), one of the major components of ECM, mediates wide variety of cellular interactions including cell adhesion, migration, proliferation and differentiation. In this study, we used synthetic peptides based...
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A case of extratubal secondary trophoblastic implants after laparoscopic treatment of ectopic pregnancy

Lee JH, Kim SR

  • KMID: 2273357
  • Korean J Obstet Gynecol.
  • 2008 May;51(5):584-587.
Persistent ectopic pregnancy (PEP) is defined as persisting pregnancy after conservative surgical treatment of ectopic pregnancy. PEP usually occurs in the original implantation site after incomplete removal of the trophoblast,...
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Treatment of chronic hepatitis C

Jun DW

  • KMID: 2342151
  • J Korean Med Assoc.
  • 2012 Nov;55(11):1113-1120.
In the past 10 years, the standard treatment for chronic hepatitis C has been pegylated interferon and ribavirin for 24 to 48 weeks, based on genotype. Until now, fixed schedule...
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Biodistribution of 99mTc Tricarbonyl Glycine Oligomers

Jang BS, Lee JS, Rho JK, Park SH

  • KMID: 1432306
  • Toxicol Res.
  • 2012 Dec;28(4):235-240.
99mTc tricarbonyl glycine monomers, trimers, and pentamers were synthesized and evaluated for their radiolabeling and in vivo distribution characteristics. We synthesized a 99mTc-tricarbonyl precursor with a low oxidation state (I)....
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Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with synthetic cell binding peptide sequences

Choi H, Park NJ, Jamiyandorj O, Hong MH, Oh S, Park YB, Kim S

PURPOSE: The aim of this study was to evaluate the improvement of osteogenic potential of biphasic calcium phosphate (BCP) bone substitute coated with synthetic cell-binding peptide sequences in a standardized...
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The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application

Kim DH, Lim YY, Kim HM, Kim SY, Kim BJ, Park SG, Lee T, Cho SM

  • KMID: 2052551
  • Toxicol Res.
  • 2012 Mar;28(1):51-56.
A novel synthetic hexapeptide (SFKLRY-NH2) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the...
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Ingestion Exposure to Nitrosamines in Chlorinated Drinking Water

Kim H, Han K

  • KMID: 2380153
  • Environ Health Toxicol.
  • 2011 ;26(1):e2011003.
OBJECTIVES: N-Nitrosodimethylamine (NDMA) is classified as a probable human carcinogen by the United States Environmental Protection Agency (US EPA) and is formed during the chlorination of municipal drinking water. In...
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The Therapeutic Approaches for Hepatitis C Virus: Protease Inhibitors and Polymerase Inhibitors

Kwo PY, Vinayek R

  • KMID: 2284229
  • Gut Liver.
  • 2011 Dec;5(4):406-417.
The current standard of care for hepatitis C infection is peginterferon/ribavirin (PegIFN/RBV). We are entering the era where direct-acting antiviral agents (DAAs) will be added to PegIFN/RBV, leading to higher...
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Effect of Ritonavir-boosting on Atazanavir Discontinuation due to Jaundice in HIV-infected Koreans

Choe PG, Park WB, Song KH, Bang JH, Kim ES, Park SW, Kim HB, Kim NJ, Oh MD, Choe KW

BACKGROUND: Data regarding differences of intolerance between a ritonavir-unboosted and a ritonavir-boosted atazanavir regimen in HIV-infected Koreans is limited. MATERIALS AND METHODS: A review was conducted of the incidence of severe...
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Oral vs. Intravenous Administration of N-acetylcysteine in the Acetaminophen Poisoning

Chae HJ, Rhee NG, Kim HJ, You JS, Chung SP, Lee HS

  • KMID: 1426777
  • J Korean Soc Clin Toxicol.
  • 2012 Dec;10(2):97-102.
PURPOSE: Serious acetaminophen (AAP) poisoning causes hepatotoxicity. N-acetylcysteine (NAC) is the most effective therapy for AAP poisoning and can be administered orally and intravenously (IV). Several studies have compared the...
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A New Synthesis of TE2A-a Potential Bifunctional Chelator for (64)Cu

Pandya DN, Kim JY, Kwak W, Park JC, Gawande MB, An GI, Ryu EK, Yoo J

  • KMID: 1455394
  • Nucl Med Mol Imaging.
  • 2010 Sep;44(3):185-192.
PURPOSE: The development of a new bifunctional chelator, which holds radiometals strongly in living systems, is a prerequisite for the successful application of disease-specific biomolecules to medical diagnosis and therapy....
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Extended Blood Drug Concentrations in Extended Release Formulated Acetaminophen Overdose Patients

Bum JH, Rhee N, Kim MJ, Park JS, Kim HJ, Chung SP, Lee HS

  • KMID: 2101638
  • J Korean Soc Clin Toxicol.
  • 2011 Dec;9(2):71-76.
PURPOSE: The Rumack-Matthew nomogram cannot be applied in managing overdose by extended release (ER) preparation acetaminophen (AAP). This study analyzed the clinical characteristics of ER preparation AAP overdose in order...
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Effect of Augmentation Therapy with Atypical Antipsychotics on Weight Gain of Major Depressive Inpatients: A Preliminary Study

Seo HJ, Jung YE, Kim SH, Chae JH, Jun TY, Kim KS, Bahk WM

  • KMID: 2287421
  • Korean J Psychopharmacol.
  • 2008 Jul;19(4):209-216.
OBJECTIVE: Few studies have investigated the effect of atypical antipsychotics augmentation with antidepressant in patients with depression. We monitored the weight of major depressive patients treated with either standard or...
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The Use of Gabexate Mesylate and Ulinastatin for the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Yoo YW, Cha SW, Kim A, Na SY, Lee YW, Kim SH, Lee HI, Lee YJ, Yang HW, Jung SH

  • KMID: 2284273
  • Gut Liver.
  • 2012 Apr;6(2):256-261.
BACKGROUND/AIMS: Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography (ERCP). Only a few pharmacologic agents have been shown to have potential efficacy for the prophylactic treatment of post-ERCP...
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Co-expression of CdtA and CdtC subunits of cytolethal distending toxin from Aggregatibacter actinomycetemcomitans

Lee SJ, Lee KY, Kim HS

  • KMID: 2321649
  • J Korean Acad Periodontol.
  • 2009 Aug;39(Suppl):231-237.
PURPOSE: Cytolethal distending toxin (CDT) is a family of heat-labile cytotoxins produced by several gram-negative mucosa-associated pathogens, including Aggregatibacter actinomycetemcomitans. CDT is well known to be capable of inducing growth...
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