- 13-week subchronic toxicity study of a novel ginsenoside composition from ginseng leaves in rats
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Shin WH, Ri Y, Do SG, Lee YC, Park SJ
- KMID: 2312122
- Lab Anim Res.
- 2014 Sep;30(3):112-122.
- doi: 10.5625/lar.2014.30.3.112
UG0712 is a new ginsenoside extract processed from ginseng leaves. A subchronic toxicity study of UG0712 was conducted in male and female SD rats. Rats were treated with UG0712 at... -
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- Comparative Study of First-in-Human Dose Estimation Approaches using Pharmacometrics
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Baek IH
- KMID: 2358067
- Korean J Clin Pharm.
- 2016 Jun;26(2):150-162.
- doi: 10.0000/kjcp.2016.26.2.150
OBJECTIVE: First-in-human dose estimation is an essential approach for successful clinical trials for drug development. In this study, we systematically compared first-in-human dose and human pharmacokinetic parameter estimation approaches. METHODS: First-in-human... -
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- 4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
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Yu WJ, Lee IC, Lee J, Lee SM, Kim SH, Baek HS, Moon C, Kim SH, Chung YH, Kim JC
- KMID: 2312103
- Lab Anim Res.
- 2013 Mar;29(1):48-54.
- doi: 10.5625/lar.2013.29.1.48
The present study investigated the potential subacute toxicity of 1,4-dichlorobutane by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to male... -
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- Acute Oral or Dermal and Repeated Dose 90-Day Oral Toxicity of Tetrasodium Pyrophosphate in Spraque Dawley (SD) Rats
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Seo DS, Kwon M, Sung HJ, Park CB
- KMID: 2380164
- Environ Health Toxicol.
- 2011 ;26(1):e2011014.
OBJECTIVES: Tetrasodium pyrophosphate (TSP) is used in processed meat products, as an emulsifier in cheese, and as a color preservative in soybean paste. However, little is known about its toxicity.... -
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- Risk assessment of di(2-ethylhexyl) phthalate in the workplace
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Kim HY
- KMID: 2469667
- Environ Health Toxicol.
- 2016 ;31(1):e2016011.
- doi: 10.5620/eht.e2016011
OBJECTIVES: A hazard assessment of di(2-ethylhexyl) phthalate (DEHP), a commonly used workplace chemical, was conducted in order to protect the occupational health of workers. A literature review, consisting of both... -
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- Effect of repeated Paecilomyces japonica treatment on rats
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Kim YB, Hong DH, Cho ES, Im W, Kim IH, Son HY
- KMID: 1700788
- Korean J Vet Res.
- 2014 Mar;54(1):31-38.
Cordyceps is a fungus used as a traditional medicine in China, Japan, and Korea. Paecilomyces (P.) japonica is a new cordyceps that was recently cultivated on silkworm pupae in Korea.... -
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- Acute and 13-week subchronic toxicological evaluations of turanose in mice
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Chung JY, Lee J, Lee D, Kim E, Shin JH, Seok PR, Yoo SH, Kim Y
- KMID: 2395299
- Nutr Res Pract.
- 2017 Dec;11(6):452-460.
- doi: 10.4162/nrp.2017.11.6.452
BACKGROUND/OBJECTIVES: Turanose, α-D-glucosyl-(1→3)-α-D-fructose, is a sucrose isomer which naturally exists in honey. To evaluate toxicity of turanose, acute and subchronic oral toxicity studies were conducted with ICR mice. MATERIALS AND METHODS:... -
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- Evaluation of Maternal Toxicity in Rats Exposed to Multi-Wall Carbon Nanotubes during Pregnancy
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Lim JH, Kim SH, Lee IC, Moon C, Kim SH, Shin DH, Kim HC, Kim JC
- KMID: 2380156
- Environ Health Toxicol.
- 2011 ;26(1):e2011006.
OBJECTIVES: The present study investigated the potential adverse effects of multi-wall carbon nanotubes (MWCNTs) on pregnant dams and embryonic development following maternal exposure in rats. METHODS: MWCNTs were orally administered to... -
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- Evaluation of 2-week repeated oral dose toxicity of 100 nm zinc oxide nanoparticles in rats
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Ko JW, Hong ET, Lee IC, Park SH, Park JI, Seong NW, Hong JS, Yun HI, Kim JC
- KMID: 2312131
- Lab Anim Res.
- 2015 Sep;31(3):139-147.
- doi: 10.5625/lar.2015.31.3.139
The aim of this study was to verify subacute oral dose toxicity of positively charged 100 nm zinc oxide (ZnO(AE100[+])) nanoparticles (NPs) in Sprague-Dawley rats. ZnO(AE100[+]) NPs were administered to... -
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- Specific nephrotoxicity and cardiotoxicity of BT-CAL(R), Sigma Anti-bonding Molecule Calcium Carbonate, in mice
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Jang JY, Cai J, Kim J, Kyung J, Kim D, Choi EK, Kim Y, Kim KS, Park D, Kang HG, Kim YB
- KMID: 2312097
- Lab Anim Res.
- 2013 Mar;29(1):7-11.
- doi: 10.5625/lar.2013.29.1.7
According to a high anti-osteoporotic efficacy of Sigma Anti-bonding Molecule Calcium Carbonate (SAC), repeated-dose toxicities of SAC were investigated to assess its feasibility as drug or functional food ingredient. Male... -
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- Toxicity of Methylcyclohexane and Its Effect on the Reproductive System in SD Rats
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Kim HY, Kang MG, Kim TG, Kang CW
- KMID: 2317026
- Saf Health Work.
- 2011 Sep;2(3):290-300.
OBJECTIVES: There is limited data regarding the toxicity of methylcyclohexane, despite its wide use in rubber adhesives, paint diluents, and cleansing agents. This study aimed to verify the toxicity and... -
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- Increased Nephrotoxicity after Combined Administration of Melamine and Cyanuric Acid in Rats
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Park D, Kim TK, Choi YJ, Lee SH, Bae DK, Yang G, Yang YH, Joo SS, Choi EK, Ahn B, Kim JC, Kim KS, Kim YB
- KMID: 2391854
- Lab Anim Res.
- 2011 Mar;27(1):25-28.
- doi: 10.5625/lar.2011.27.1.25
Renal toxicity by melamine in combination with cyanuric acid (1:1) was investigated. Male rats were orally administered melamine plus cyanuric acid (5, 50 or 400 mg/kg each) for 3 days.... -
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- Safety Evaluation of Human Fibroblasts in Mice: Tumorigenicity, 13-week Toxicity and Distribution Studies
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Choi HJ, Kwon E, Sohn JH, Che JH, Lee KH, Kim JW, Choi J, Kang BC
- KMID: 2312064
- Lab Anim Res.
- 2010 Jun;26(2):181-196.
- doi: 10.5625/lar.2010.26.2.181
Human fibroblasts were developed for cellular therapy with the aim of correcting of depressed scars, but the safety of that in vivo is unclear. In this study, we assessed the... -
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- Toxicity of fermented soybean product (cheonggukjang) manufactured by mixed culture of Bacillus subtilis MC31 and Lactobacillus sakei 383 on liver and kidney of ICR mice
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Lee YJ, Kim JE, Kwak MH, Go J, Son HJ, Kim DS, Kang BC, Lee HS, Hwang DY
- KMID: 1707444
- Lab Anim Res.
- 2014 Jun;30(2):54-63.
- doi: 10.5625/lar.2014.30.2.54
To investigate the toxic effects of cheonggukjang (CKJ) manufactured using mixed cultures of Bacillus subtilis MC31 and Lactobacillus sakei 383 on the liver and kidney of ICR mice, an alteration... -
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- Subacute Oral Toxicity Study of Korean Red Ginseng Extract in Sprague-Dawley Rats
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Park SJ, Lim KH, Noh JH, Jeong EJ, Kim YS, Han BC, Lee SH, Moon KS
- KMID: 2317847
- Toxicol Res.
- 2013 Dec;29(4):285-292.
Ginseng is a well-known traditional medicine used in Asian countries for several thousand years, and it is currently applied to medicine, cosmetics, and nutritional supplements due to its many healing... -
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- Determining NOEL/NOAEL in Repeated-dose Toxicity Studies, When the Low Dose Group Shows Significant Difference in Quantitative Data
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Kobayashi , Pillai KS, Michael M, Cherian KM, Ohnishi M
- KMID: 2312058
- Lab Anim Res.
- 2010 Jun;26(2):133-137.
- doi: 10.5625/lar.2010.26.2.133
In repeated-dose 28-day oral toxicity study design, the low dose is fixed as the no observed effect level (NOEL). But, in practice the low dose usually shows significant difference in... -
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- Hepatotoxicity and nephrotoxicity of gallotannin-enriched extract isolated from Galla Rhois in ICR mice
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Go J, Kim JE, Koh EK, Song SH, Seung JE, Park CK, Lee HA, Kim HS, Lee JH, An BS, Yang SY, Lim Y, Hwang DY
- KMID: 2312126
- Lab Anim Res.
- 2015 Sep;31(3):101-110.
- doi: 10.5625/lar.2015.31.3.101
To evaluate the hepatotoxicity and nephrotoxicity of Galla Rhois (GR) toward the liver and kidney of ICR mice, alterations in related markers including body weight, organ weight, urine composition, liver... -
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- Preclinical safety assessment of Angelica acutiloba using a 13-week repeated dose oral toxicity study in rats
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Yun JW, Kwon E, Kim SH, You JR, Kim YS, Park IA, Kim HH, Che JH, Kang BC
- KMID: 2391095
- Lab Anim Res.
- 2017 Sep;33(3):223-230.
- doi: 10.5625/lar.2017.33.3.223
Angelica acutiloba (AA), a Japanese species of Danggui, has been used worldwide as a traditional herbal medicine with several bioactivities including anti-diabetic, anti-allergic, anti-inflammatory, anti-tumor, and anti-obesity. However, there is... -
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- The Efficacy and Safety of Non-Nutritive Sweeteners
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Ju DL
- KMID: 2173855
- J Korean Diabetes.
- 2015 Dec;16(4):281-286.
- doi: 10.4093/jkd.2015.16.4.281
High intake of added sugars increases the risk for obesity, type 2 diabetes, and cardiovascular disease. Non-nutritive sweeteners (NNS) are widely used in many beverages and food products to reduce... -
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- Establishment of NOAEL for intracavernous injections of human bone marrow-derived mesenchymal stem cells in rats
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Kim JK, Jang MJ, Kim BH, Choi KR, Song G, Shin HC, Suh N, Kim YM, You D, Ahn TY, Kim CS
- KMID: 2466797
- Investig Clin Urol.
- 2020 Jan;61(1):88-98.
- doi: 10.4111/icu.2020.61.1.88
PURPOSE: To assess the possible negative health effects of human bone marrow-derived mesenchymal stem cells (hBMSCs) on fertility and early embryonic development following intracavernous injections in rats. MATERIALS AND METHODS: A... -
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