- Neuroprotectants in the Era of Reperfusion Therapy
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Chamorro A
- KMID: 2424423
- J Stroke.
- 2018 May;20(2):197-207.
- doi: 10.5853/jos.2017.02901
For decades, numerous pharmacological and non-pharmacological strategies have been evaluated without success to limit the consequences of the ischemic cascade, but more rarely the therapies were explored as add on... -
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- Neuroprotection in Schizophrenia and Its Therapeutic Implications
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Kim YK, Na KS
- KMID: 2387127
- Psychiatry Investig.
- 2017 Jul;14(4):383-391.
- doi: 10.4306/pi.2017.14.4.383
Schizophrenia is a chronic and debilitating mental disorder. The persisting negative and cognitive symptoms that are unresponsive to pharmacotherapy reveal the impairment of neuroprotective aspects of schizophrenia. In this review,... -
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- The Management of Cerebrovascular Accident
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Cho KH
- KMID: 2347498
- J Korean Med Assoc.
- 2002 Dec;45(12):1450-1458.
- doi: 10.5124/jkma.2002.45.12.1450
Most cerebrovascular diseases (CVA) are manifest by the abrupt onset of a focal neurologic deficit. The deficit may remain fixed or may rapidly improve or progressively worsen. Therefore, the main... -
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- Targeted temperature management for ischemic stroke
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Hong JM
- KMID: 2470467
- J Neurocrit Care.
- 2019 Dec;12(2):67-73.
- doi: 10.18700/jnc.190100
Therapeutic hypothermia (TH) or targeted temperature management is an intentional cooling or temperature control technique using a thermostatic equipment (i.e., surface, endovascular, and focal devices) for specific therapeutic purposes. Given... -
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- Spinal Cord Injury and Neuro-Regeneration
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Ahn JH, Park HY, Kim YH
- KMID: 2469881
- J Korean Orthop Assoc.
- 2019 Dec;54(6):498-508.
- doi: 10.4055/jkoa.2019.54.6.498
Recent advances in the understanding of the pathophysiology of spinal cord injury (SCI) and new therapeutic approaches have provided promising results for this incurable and debilitating central nervous system injury.... -
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- Isoflurane Preconditioning Induces Neuroprotection by Up-Regulation of TREK1 in a Rat Model of Spinal Cord Ischemic Injury
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Wang K, Kong X
- KMID: 2351673
- Biomol Ther.
- 2016 Sep;24(5):495-500.
- doi: 10.4062/biomolther.2015.206
This study aimed to explore the neuroprotection and mechanism of isoflurane on rats with spinal cord ischemic injury. Total 40 adult male Sprague-Dawley rats were divided into the four groups... -
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- Regulation of Neural Stem Cell Fate by Natural Products
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Kim HJ
- KMID: 2432062
- Biomol Ther.
- 2019 Jan;27(1):15-24.
- doi: 10.4062/biomolther.2018.184
Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent... -
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- TLR5 Activation through NF-κB Is a Neuroprotective Mechanism of Postconditioning after Cerebral Ischemia in Mice
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Jeong J, Kim S, Lim DS, Kim SH, Doh H, Kim SD, Song YS
- KMID: 2389008
- Exp Neurobiol.
- 2017 Aug;26(4):213-226.
- doi: 10.5607/en.2017.26.4.213
Postconditioning has been shown to protect the mouse brain from ischemic injury. However, the neuroprotective mechanisms of postconditioning remain elusive. We have found that toll-like receptor 5 (TLR5) plays an... -
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- HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice
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Kim T, Song S, Park Y, Kang S, Seo H
- KMID: 2458548
- Exp Neurobiol.
- 2019 Aug;28(4):504-515.
- doi: 10.5607/en.2019.28.4.504
Parkinson’s disease (PD) is one of the late-onset neurodegenerative movement disorder. Major pathological markers of PD include progressive loss of dopaminergic neurons, Lewy body formation, genetic mutations, and environmental factors.... -
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- Protective effect of the aerial parts of Silybum marianum against amyloid β protein (25-35)-induced neuronal death in cultured neurons
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Lee HM, Jang JY, Seong YH
- KMID: 2368692
- J Biomed Transl Res.
- 2016 Dec;17(4):109-114.
- doi: 10.12729/jbtr.2016.17.4.109
Alzheimer's disease (AD), a progressive neurodegenerative disorder that deprives the patient of memory, is associated mainly with extracellular senile plaque induced by the accumulation of amyloid β protein (Aβ). Silybum... -
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- Management and prevention of third molar surgery-related trigeminal nerve injury: time for a rethink
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Leung YY
- KMID: 2461475
- J Korean Assoc Oral Maxillofac Surg.
- 2019 Oct;45(5):233-240.
- doi: 10.5125/jkaoms.2019.45.5.233
Trigeminal nerve injury as a consequence of lower third molar surgery is a notorious complication and may affect the patient in long term. Inferior alveolar nerve (IAN) and lingual nerve... -
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- Intranasal Administration of Interleukin-1 Receptor Antagonist in a Transient Focal Cerebral Ischemia Rat Model
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Lee JH, Kam EH, Kim JM, Kim SY, Kim EJ, Cheon SY, Koo BN
- KMID: 2375034
- Biomol Ther.
- 2017 Mar;25(2):149-157.
- doi: 10.4062/biomolther.2016.050
The interleukin-1 receptor antagonist (IL-1RA) is a potential stroke treatment candidate. Intranasal delivery is a novel method thereby a therapeutic protein can be penetrated into the brain parenchyma by bypassing... -
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- Beneficial Effects of Silibinin Against Kainic Acid-induced Neurotoxicity in the Hippocampus in vivo
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Kim S, Jung UJ, Oh YS, Jeon MT, Kim HJ, Shin WH, Hong J, Kim SR
- KMID: 2398431
- Exp Neurobiol.
- 2017 Oct;26(5):266-277.
- doi: 10.5607/en.2017.26.5.266
Silibinin, an active constituent of silymarin extracted from milk thistle, has been previously reported to confer protection to the adult brain against neurodegeneration. However, its effects against epileptic seizures have... -
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- Neuroprotective Effect of Duloxetine on Chronic Cerebral Hypoperfusion-Induced Hippocampal Neuronal Damage
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Park JA, Lee CH
- KMID: 2429050
- Biomol Ther.
- 2018 Mar;26(2):115-120.
- doi: 10.4062/biomolther.2016.248
Chronic cerebral hypoperfusion (CCH), which is associated with onset of vascular dementia, causes cognitive impairment and neuropathological alterations in the brain. In the present study, we examined the neuroprotective effect... -
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- CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease
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Chung YC, Shin WH, Baek JY, Cho EJ, Baik HH, Kim SR, Won SY, Jin BK
- KMID: 2327678
- Exp Mol Med.
- 2016 Jan;48(1):e205.
- doi: 10.1038/emm.2015.100
The cannabinoid (CB2) receptor type 2 has been proposed to prevent the degeneration of dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. However, the mechanisms underlying CB2 receptor-mediated neuroprotection in MPTP mice... -
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- Astrocytic Expression of CTMP Following an Excitotoxic Lesion in the Mouse Hippocampus
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Shin N, Yi MH, Kim S, Baek H, Triantafillu UL, Park J, Kim DW
- KMID: 2368652
- Exp Neurobiol.
- 2017 Feb;26(1):25-32.
- doi: 10.5607/en.2017.26.1.25
Akt (also known as protein kinase B, PKB) has been seen to play a role in astrocyte activation of neuroprotection; however, the underlying mechanism on deregulation of Akt signaling in... -
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- Pharmacologic Characteristics of Corticosteroids
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Samuel S, Nguyen T, Choi HA
- KMID: 2405758
- J Neurocrit Care.
- 2017 Dec;10(2):53-59.
- doi: 10.18700/jnc.170035
Corticosteroids (CSs) are used frequently in the neurocritical care unit mainly for their anti-inflammatory and immunosuppressive effects. Despite their broad use, limited evidence exists for their efficacy in diseases confronted... -
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- Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons
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Yoo JY, Kim HB, Yoo SY, Yoo HI, Song DY, Baik TK, Lee JH, Woo RS
- KMID: 2466700
- Anat Cell Biol.
- 2019 Dec;52(4):462-468.
- doi: 10.5115/acb.19.210
The hippocampus is one of the most important brain areas of cognition. This region is particularly sensitive to hypoxia and ischemia. Neuregulin-1 (NRG1) has been shown to be able to... -
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- Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy in Newborn Infants
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Sung IK
- KMID: 2396829
- Neonatal Med.
- 2017 Nov;24(4):145-156.
- doi: 10.5385/nm.2017.24.4.145
Neonatal hypoxic-ischemic encephalopathy (HIE) is an ongoing process, which may persist for weeks to years after an acute asphyxial insult, causing delayed programmed cell death. The typical clinical signs and... -
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- Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents
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Khoshnam S, Winlow W, Farbood Y, Moghaddam , Farzaneh M
- KMID: 2389204
- J Stroke.
- 2017 May;19(2):166-187.
- doi: 10.5853/jos.2016.01368
Stroke is one of the leading causes of death and physical disability worldwide. The consequences of stroke injuries are profound and persistent, causing in considerable burden to both the individual... -
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