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Use of Nefopam in Perioperative Pain Management; Keeping Nefopam in between

Choi JI

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The Potential Role of Intrathecal Nefopam in the Management of Neuropathic Pain

Ghobadifar MA, Kalani N

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Efficacy of Nefopam Analgesia for Trauma Patients in the Emergency Department

Lim TY, Kim JY, Choi SH, Yoon YH

PURPOSE: Nefopam is a centrally acting non-narcotic analgesic that has mostly been used for postoperative pain. We examined the efficacy of nefopam analgesia (alone and in combination with ketorolac) for...
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The Analgesic Effect of Nefopam with Fentanyl at the End of Laparoscopic Cholecystectomy

Lee JH, Kim JH, Cheong YK

BACKGROUND: Nefopam is a centrally acting analgesic that is used to control pain. The aim of this study was to find an appropriate dose of nefopam that demonstrates an analgesic...
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Antinociceptive Effect of Intrathecal Nefopam and Interaction with Morphine in Formalin-Induced Pain of Rats

Cho SY, Park AR, Yoon MH, Lee HG, Kim WM, Choi JI

BACKGROUND: Nefopam, a non-opiate analgesic, has been regarded as a substance that reduces the requirement for morphine, but conflicting results have also been reported. The inhibition of monoamine reuptake is...
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The Role of Spinal Dopaminergic Transmission in the Analgesic Effect of Nefopam on Rat Inflammatory Pain

Kim DY, Chae JW, Lim CH, Heo BH, Park KS, Lee HG, Choi JI, Yoon MH, Kim WM

BACKGROUND: Nefopam has been known as an inhibitor of the reuptake of monoamines, and the noradrenergic and/or serotonergic system has been focused on as a mechanism of its analgesic action....
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Spinal Noradrenergic Modulation and the Role of the Alpha-2 Receptor in the Antinociceptive Effect of Intrathecal Nefopam in the Formalin Test

Jeong SH, Heo BH, Park SH, Kim WM, Lee HG, Yoon MH, Choi JI

BACKGROUND: Nefopam has shown an analgesic effect on acute pain including postoperative pain. The reuptake of monoamines including serotonin and noradrenaline has been proposed as the mechanism of the analgesic...
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Postoperative pain and side effects after thyroidectomy: randomized double blind study comparing nefopam and ketorolac

Yoo B, Kwon JY, Hwang BY, Hong JM, Kim TK, Kim HK

  • KMID: 1797471
  • Anesth Pain Med.
  • 2014 Apr;9(2):110-114.
BACKGROUND: Nefopam is a centrally acting, non-opioid analgesic drug used to reduce opioid consumption and so reduce the prevalence of postoperative nausea and vomiting (PONV). This study compared and assessed...
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Status Epilepticus Caused by Nefopam

Park YS, Kim YB, Kim JM

Nefopam, a centrally acting analgesic, has been used to control postoperative pain. Reported adverse effects are anticholinergic, cardiovascular or neuropsychiatric. Neurologic adverse reactions to nefopam are confusion, hallucinations, delirium and...
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Comparison of effects of intraoperative nefopam and ketamine infusion on managing postoperative pain after laparoscopic cholecystectomy administered remifentanil

Choi SK, Yoon MH, Choi JI, Kim WM, Heo BH, Park KS, Song JA

BACKGROUND: Although intraoperative opioids provide more comfortable anesthesia and reduce the use of postoperative analgesics, it may cause opioid induced hyperalgesia (OIH). OIH is an increased pain response to opioids...
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Comparison of effect of electroacupuncture and nefopam for prevention of postanesthetic shivering in patients undergoing urologic operation under spinal anesthesia

Hong JH, Kim SJ, Hwang MS

BACKGROUND: Shivering during spinal anesthesia is a frequent complication and is induced by the core-to-peripheral redistribution of heat. Nefopam has minimal side effects and prevents shivering by reducing the shivering...
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Nefopam does not influence onset and recovery profiles of rocuronium-induced neuromuscular block: a prospective, double-blinded, randomized, controlled study

So KY, Moon HM, Kim SH

BACKGROUND: We investigated the hypothesis that pretreatment with nefopam 20 mg would influence the onset and recovery profiles of rocuronium-induced neuromuscular block. METHODS: After Institutional Review Board approval, 134 patients, aged...
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Comparison of meperidine and nefopam for prevention of shivering during spinal anesthesia

Kim YA, Kweon TD, Kim M, Lee HI, Lee YJ, Lee KY

BACKGROUND: Shivering is a frequent event during spinal anesthesia and meperidine is a well-known effective drug for prevention and treatment of shivering. Nefopam is a non-opiate analgesic and also known...
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Combination of nefopam and remifentanil is more effective to reduce rocuronium-induced withdrawal response compared with remifentanil alone: a prospective, double-blinded, randomized control study

Jung KT, Kim SH, So KY, Moon HM

BACKGROUND: We investigated the effect of combination of nefopam and remifentanil under the hypothesis that nefopam would effectively prevent rocuronium-induced withdrawal response by blocking serotonin receptors and providing a synergistic...
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Effects of nefopam on catheter-related bladder discomfort in patients undergoing ureteroscopic litholapaxy

Cheon YW, Kim SH, Paek JH, Kim JA, Lee YK, Min JH, Cho HR

BACKGROUND: Patients who undergo urinary catheterization may experience postoperative catheter-related bladder discomfort (CRBD). Previous studies have indicated that drugs with antimuscarinic effects could reduce the incidence and severity of CRBD....
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Effects of warmed carrier fluid on nefopam injection-induced pain

Cho HR, Kim SH, Kim JA, Min JH, Lee YK

BACKGROUND: Nefopam is a non-opioid, non-steroidal analgesic drug with fewer adverse effects than narcotic analgesics and nonsteroidal anti-inflammatory drugs, and is widely used for postoperative pain control. Because nefopam sometimes...
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Effects of Nefopam on Streptozotocin-Induced Diabetic Neuropathic Pain in Rats

Nam JS, Cheong YS, Karm MH, Ahn HS, Sim JH, Kim JS, Choi SS, Leem JG

BACKGROUND: Nefopam is a centrally acting non-opioid analgesic agent. Its analgesic properties may be related to the inhibitions of monoamine reuptake and the N-methyl-D-aspartate (NMDA) receptor. The antinociceptive effect of...
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Enhancement of Antinociception by Co-administrations of Nefopam, Morphine, and Nimesulide in a Rat Model of Neuropathic Pain

Saghaei E, Moini Zanjani T, Sabetkasaei M, Naseri K

BACKGROUND: Neuropathic pain is a chronic pain due to disorder in the peripheral or central nervous system with different pathophysiological mechanisms. Current treatments are not effective. Analgesic drugs combined can...
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The Effect of Nefopam on Postoperative Fentanyl Consumption: A Randomized, Double-blind Study

Moon JY, Choi SS, Lee SY, Lee MK, Kim JE, Lee JE, Lee SH

BACKGROUND: Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug. The concomitant use of opioids and nefopam is believed to have many advantages over the administration of opioids alone for...
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A comparison between ketorolac and nefopam as adjuvant analgesics for postoperative patient-controlled analgesia: a randomized, double-blind, prospective study

Son JS, Doo A, Kwon YJ, Han YJ, Ko S

BACKGROUND: We compared the analgesic efficacy and side effects of ketorolac and nefopam that were co-administered with fentanyl via intravenous patient-controlled analgesia. METHODS: One hundred and sixty patients scheduled for laparoscopic...
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