- Regulation of NFATc1 in Osteoclast Differentiation
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Kim JH, Kim N
- KMID: 2170050
- J Bone Metab.
- 2014 Nov;21(4):233-241.
- doi: 10.11005/jbm.2014.21.4.233
Osteoclasts are unique cells that degrade the bone matrix. These large multinucleated cells differentiate from the monocyte/macrophage lineage upon stimulation by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and receptor... -
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- The Molecular Mechanism of Baicalin on RANKL-induced Osteoclastogenesis in RAW264.7 Cells
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Ko SY
- KMID: 1431096
- Int J Oral Biol.
- 2013 Jun;38(2):67-72.
This study examined the anti-osteoclastogenic effects of baicalin on receptor activator of NF-kB ligand (RANKL)-induced RAW264.7 cells. Baicalin is a flavonoid that is produced by Scutellaria baicalensis and is known... -
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- Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
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Song MK, Lee ZH, Kim HH
- KMID: 2359886
- Exp Mol Med.
- 2015 Dec;47(12):e199.
- doi: 10.1038/emm.2015.94
Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone... -
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- Downregulation of NFAT2 promotes melanogenesis in B16 melanoma cells
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Lee YS, Kim DW, Kim S, Choi HI, Lee Y, Kim CD, Lee JH, Lee SD, Lee YH
- KMID: 1455344
- Anat Cell Biol.
- 2010 Dec;43(4):303-309.
- doi: 10.5115/acb.2010.43.4.303
Nuclear factor of activated T-cells (NFAT) proteins are, calcium-regulated transcription factors, key regulator of stimulation-dependent gene activation. In our microarray analysis for the genes expressed in human black and white... -
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- Expression of TonEBP by Hypertonic and Hyperosmolar Stress in RGC-5 Cells
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Woo JE, Kwon MY, Chung SW, Woo JM
- KMID: 2338859
- J Korean Ophthalmol Soc.
- 2014 Aug;55(8):1195-1201.
PURPOSE: In order to determine whether the Tonicity responsive enhancer binding protein (TonEBP) is expressed by hypertonic and hyperosmolar stress, TonEBP expression was investigated in the retinal ganglion cell (RGC)... -
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- Extracts of Flavoparmelia sp. Inhibit Receptor Activator of Nuclear Factor-κB Ligand-Mediated Osteoclast Differentiation
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Kim KJ, Lee Y, Jeong MH, Hur JS, Son YJ
- KMID: 2448959
- J Bone Metab.
- 2019 May;26(2):113-121.
- doi: 10.11005/jbm.2019.26.2.113
BACKGROUND: Osteoporosis is a geriatric disease with diminished bone density. The increase in the number of patients and medical expenses due to a global aging society are recognized as problems.... -
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- NF-kappaB-Mediated Regulation of Osteoclastogenesis
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Boyce BF, Xiu Y, Li J, Xing L, Yao Z
- KMID: 2407101
- Endocrinol Metab.
- 2015 Mar;30(1):35-44.
- doi: 10.3803/EnM.2015.30.1.35
Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusion of bone marrow-derived myeloid lineage precursors that circulate in the blood. Major advances in understanding... -
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- Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells
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Kim WK, Sul OJ, Kwak JS, Hur HY, Latour AM, Koller BH, Kwon BS, Jeong CS
- KMID: 1115264
- Exp Mol Med.
- 2010 Dec;42(12):805-810.
- doi: 10.3858/emm.2010.42.12.083
Tumor necrosis factor receptor-related 2 (TR2, HVEM or TNFRSF-14) plays an important role in immune responses, however, the mechanisms regulating its expression are unclear. To understand the control of TR2... -
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- NFATc1 and NFATc3 is Involved in the Expression of Receptor Activator of NF-kappaB Ligand in Activated T Lymphocytes
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Heo SJ, Park HJ, Baek JH
- KMID: 1431127
- Int J Oral Biol.
- 2013 Mar;38(1):37-42.
Receptor activator of NF-kappaB ligand (RANKL) is an essential cytokine for osteoclast differentiation, activation and survival. T lymphocytes such as T17 cells, a subset of T helper cells that produce... -
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- Methanol Extract of Croton Pycnanthus Benth. Inhibits Osteoclast Differentiation by Suppressing the MAPK and NF-kappaB Signaling Pathways
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Lee J, Kim HH
- KMID: 2170055
- J Bone Metab.
- 2014 Nov;21(4):269-275.
- doi: 10.11005/jbm.2014.21.4.269
BACKGROUND: Osteoclasts are differentiated from monocytes/macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-kappaB) ligand (RANKL). Croton pycnanthus Benth. (CPB) is a herbal plant that belongs to... -
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- MSK1 regulates RANKL-induced NFATc1 expression through CREB and c-Fos
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Ha J, Hwang JH, Kwon SG, Park DH, Kim TW, Kang DG, Kang KH, Kim IS, Kim CW
- KMID: 2286279
- J Biomed Res.
- 2015 Jun;16(2):35-39.
- doi: 10.12729/jbr.2015.16.2.035
Osteoclasts originated from hematopoietic stem cells are multi-nucleated cells that can resorb the bone matrix. Receptor activator of nuclear factor kappa-B (RANK)/RANK ligand (RANKL) signaling pathway is crucial for the... -
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- Protein kinase C micron plays an essential role in hypertonicity-induced heat shock protein 70 expression
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Lim YS, Lee JS, Huang TQ, Seo JS
- KMID: 1072940
- Exp Mol Med.
- 2008 Dec;40(6):596-606.
- doi: 10.3858/emm.2008.40.6.596
Heat shock protein 70 (HSP70), which evidences important functions as a molecular chaperone and anti-apoptotic molecule, is substantially induced in cells exposed to a variety of stresses, including hypertonic stress,... -
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- Ethyl Acetate Fraction from Cudrania Tricuspidata Inhibits IL-1beta-Stimulated Osteoclast Differentiation through Downregulation of MAPKs, c-Fos and NFATc1
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Lee EG, Yun HJ, Lee SI, Yoo WH
- KMID: 1785661
- Korean J Intern Med.
- 2010 Mar;25(1):93-100.
- doi: 10.3904/kjim.2010.25.1.93
BACKGROUND/AIMS: The present study was performed to determine the effects of the ethyl acetate extract of Cudrania tricuspidata (EACT) on interleukin (IL)-1beta-stimulated receptor activator of NF-kappaB ligand (RANKL)-mediated osteoclast differentiation.... -
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- Multi-transmembrane protein K15 of Kaposi's sarcoma-associated herpesvirus targets Lyn kinase in the membrane raft and induces NFAT/AP1 activities
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Cho NH, Choi YK, Choi JK
- KMID: 1104811
- Exp Mol Med.
- 2008 Oct;40(5):565-573.
- doi: 10.3858/emm.2008.40.5.565
Viral proteins of gamma-2 herpesviruses, such as LMP2A of Epstein Barr virus (EBV) and Tip of herpesvirus saimiri (HVS) dysregulate lymphocyte signaling by interacting with Src family kinases. K15 open... -
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- Platinum nanoparticles reduce ovariectomy-induced bone loss by decreasing osteoclastogenesis
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Kim WK, Kim JC, Park HJ, Sul OJ, Lee MH, Kim JS, Choi HS
- KMID: 1397447
- Exp Mol Med.
- 2012 Jul;44(7):432-439.
Platinum nanoparticles (PtNP) exhibit remarkable antioxidant activity. There is growing evidence concerning a positive relationship between oxidative stress and bone loss, suggesting that PtNP could protect against bone loss by... -
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- Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1
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Kwak HB, Yang D, Ha H, Lee JH, Kim HN, Woo ER, Lee S, Kim HH, Lee ZH
- KMID: 1094151
- Exp Mol Med.
- 2006 Jun;38(3):256-264.
Bone is a dynamic tissue that is regulated by the activity of bone-resorbing osteoclasts and bone-forming osteoblasts. Excessive osteoclast formation causes diseases such as osteoporosis and rheumatoid arthritis. Natural substances... -
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