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Anti-inflammatory effects of IL-4 and IL-10 on Human Polymorphonuclear Leukocytes

Lee SW, Hong YS, Chun CM, Moon JD, Kim SJ, Jung IC, Yoon YH, Lee BA, Moon SW, Choi SH, Moon CK

Inflammatory responses are strictly regulated by coordination of pro-inflammatory and anti-inflammatory mediators. Interleukin-4 (IL-4) and interleukin-10 (IL-10) have typically the biologic anti-inflammatory effects on monocytes, but uncertain effects on polymorphonuclear...
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Adhesion-induced generation of oxygen free radical from human alveolar macrophages and its mechanisms

Chung MP, Yoo CG, Kim YW, Han SK, Shim YS, Han YC

  • KMID: 2317993
  • Tuberc Respir Dis.
  • 1996 Apr;43(2):210-220.
BACKGROUND: Neutrophils or monocytes separated in vitro by the adherence to plastic surface are known to be activated by surface adherence itself and subsequent experimental data might be altered by...
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Molecular Mechanisms of Neutrophil Activation in Acute Lung Injury

Yum HK

ABBREVIATIONS: Akt/PKB protein kinase B, ALI acute lung injury, ARDS acute respiratory distress syndrome, CREB C-AMP response element binding protein, ERK extracelluar signal-related kinase, fMLP fMet-Leu-Phe, G-CSF granulocyte colony-stimulating factor,...
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Evaluation of Neutrophil Activation Status According to the Phenotypes of Adult Asthma

Kim SH, Uuganbayar U, Trinh HK, Pham D, Kim N, Kim M, Sohn H, Park HS

PURPOSE: Neutrophils are considered key effector cells in the pathogenic mechanisms of airway inflammation in asthma. This study assessed the activation status of neutrophils in adult asthmatics, and the therapeutic...
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Effect of Defibrotide on Rat Reflux Esophagitis

Kim HK, Choi SR, Choi SJ, Chio MS, Shin YK

  • KMID: 1611490
  • Korean J Physiol Pharmacol.
  • 2004 Dec;8(6):319-327.
This study was aimed at evaluating the effect of defibrotide on the development of the surgically induced reflux esophagitis, on gastric secretion, lipid peroxidation, polymorphonuclear leukocytes (PMNs) accumulation, polymorphonuclear leukocytes...
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Calyculin A modulates activation of the NADPH-oxidase in Me2SO-differentiated HL-60 cells

Park JI, Uhlinger D, Chung BS, Kim IH, Kwak JY

  • KMID: 755011
  • Exp Mol Med.
  • 1998 Dec;30(4):214-220.
Human promyelocytic leukemia cells (HL-60) have been used as a model system in which to study the effects of protein phosphatase inhibitors on NADPH-oxidase activation. Since O2- is generated by...
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Protective Effect of Defibrotide on Splanchnic Injury following Ischemia and Reperfusion in Rats

Choi SR, Jeong JH, Song JH, Shin YK

  • KMID: 2071625
  • Korean J Physiol Pharmacol.
  • 2006 Apr;10(2):85-94.
A splanchic artery occlusion for 90 min followed by reperfusion of the mesenteric circulation resulted in a severe form of circulatory shock, characterized by endothelial dysfunction, severe hypotension, marked intestinal...
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In vitro Model System of Transepithelial Migration of Neutrophil by Helicobacter pylori

Jung HC, Kim JG, Kim JM, Song IS, Park SM

  • KMID: 772517
  • Korean J Gastroenterol.
  • 2003 Jul;42(1):20-26.
BACKGROUND/AIMS: Migration of neutrophil across the intestinal epithelium is a structural hallmark of active intestinal diseases. One of the characteristic histologic features of Helicobacter pylori (H. pylori) infection is...
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Chemotaxis of Blood Neutrophils from Patients with Primary Ciliary Dyskinesia

Koh YY, Sun YH, Min YG, Chi JG, Kim CK

Primary ciliary dyskinesia is characterized by chronic upper and lower respiratory infections which are caused by the grossly impaired ciliary transport. Since the cilia and neutrophils both utilize microtubular system...
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