- Autophagy and Neurodegenerative Diseases
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Paek J, Kim B
- KMID: 1813203
- J Korean Neurol Assoc.
- 2009 Aug;27(3):206-214.
Autophagy is a highly regulated cellular mechanism that results in the bulk degradation of long-lived proteins and organelles and which seems to be implicated in a variety of physiological and... -
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- New Immunosuppressive Agent: The Effects of an Antagonist IL-15/IgG Fusion Protein
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Kim YS, Chae DW, Strom TB
- KMID: 2144934
- J Korean Soc Transplant.
- 1998 Nov;12(2):173-182.
Owing to shared receptor components, the biological activities of IL-15 are similar to those of IL-2. However the patterns of tissue expression of IL-2/IL-2R alpha and IL-15/IL-15R differ. The development... -
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- Nuclear Expression of Mutant p53 protein in Transitinal Cell Carcinoma of the Bladder Detected by Immunohistochemistry: The Correlative Study with Proliferating Cell Nuclear Antigen Expression, Nucleolar Organizer Regions per Nucleus and Flow cytometric P
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Cheon J, Koh SK
- KMID: 2139403
- Korean J Urol.
- 1994 May;35(5):477-491.
We examined the nuclear overexpression of p53 protein by immunohistochemical analysis of the deparaffinized tumor tissue specimens from 45 patients with transitional cell carcinoma of the bladder. The data were... -
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- Production of Soluble VEGF Receptor Mutants for Inhibition of Angiogenesis
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Yun SY, Hong YK, Lee Y, Kim K, Kim HK, Joe YA
- KMID: 2175025
- J Korean Cancer Assoc.
- 2000 Jun;32(3):595-604.
PURPOSE: Vascular endothelial growth factor (VEGF) is a potent angiogenic factor of many solid tumors, promoting vascularization and formation of metastases. In an attempt to generate effective VEGF inhibitors, the authors constructed... -
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- Molecular Approach for Distal Renal Tubular Acidosis Associated AE1 Mutations
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Vasuvattakul S
- KMID: 1462999
- Electrolyte Blood Press.
- 2010 Jun;8(1):25-31.
- doi: 10.5049/EBP.2010.8.1.25
The molecular approaches to distal renal tubular acidosis (dRTA) associated AE1 mutations lead us to understand the genetic and pathophysiological aspects of the acidification defects. An unanticipated high value of... -
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- Correlation between Serum p53 Antibody and Tissue Expression of Mutant p53 Protein in Primary Breast Carcinoma Patients
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Ahn SH, Moon H, Han S
- KMID: 2324898
- J Korean Surg Soc.
- 2000 Oct;59(4):441-446.
PURPOSE: It has been reported that the antibody against p53 is detected in a certain proportion of patients with malignancies. The authors designed this study to investigate the correlation between... -
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- Development of cell models for high-throughput screening system of Charcot-Marie-Tooth disease type 1
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Choi YR, Jung SC, Shin J, Yoo SY, Lee JS, Joo J, Lee J, Hong YB, Choi BO
- KMID: 2055586
- J Genet Med.
- 2015 Jun;12(1):25-30.
- doi: 10.5734/JGM.2015.12.1.25
PURPOSE: Charcot-Marie-Tooth disease (CMT) is a peripheral neuropathy mainly divided into CMT type 1 (CMT1) and CMT2 according to the phenotype and genotype. Although molecular pathologies for each genetic causative... -
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- Immunohistochemical Detection of p53 Gene Mutation in Urine Samples in the Patients with Bladder Cancer
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Lee SS, Bae JY, Kang YN, Cho YR, Park NJ, Kim SY, Kim JH
- KMID: 1931648
- Korean J Cytopathol.
- 1996 Dec;7(2):144-150.
Although bladder cancers are very common, little is known about their molecular pathogenesis. It is known, that p53 alteration is found in about 60%p of muscleinvasive bladder cancer, necessiating aggressive... -
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- The Significance of p53 Expression in Serum and Tissue from Patients with Lung Cancer
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Chang JH, Sung SH
- KMID: 2318137
- Tuberc Respir Dis.
- 1998 Apr;45(2):333-340.
BACKGROUND: Lung cancer is the leading cause of cancer over the world. P53 alteration is by far the most common genetic defect in lung cancer. The mutation of p53 protein... -
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- Expressions of MAGE-3, PCNA, p21, and p53 Proteins in the Hypopharyngeal Squamous Cell Carcinoma Cell Line (PNUH-12) Analysed by Bivariate Flow Cytometry
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Chang HK, Kim DJ, Roh HJ, Hur B, Lee KD, Spagnoli
- KMID: 1725731
- Korean J Pathol.
- 2000 Nov;34(11):901-908.
MAGE (melanoma antigen gene) is a tumor specific shared antigen, presented by HLA class I molecules, which is recognized by cytotoxic T lymphocytes. MAGE proteins are expressed in malignant tumor... -
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- Selective Cytotoxic Mechanism of Homocysteine to Motor Neuronal Cells Expressing the Mutant Cu,Zn-superoxide Dismutase
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Sung JJ, Kim HJ, Kim SM, Min JH, Hong YH, Park KS, Kim M, Lee SH, Ho WK, Lee KW
- KMID: 1957679
- J Korean Neurol Assoc.
- 2006 Feb;24(1):66-75.
BACKGROUND: Mutations in Cu, Zn-superoxide dismutase (SOD1) cause about 20% of familial amyotrophic lateral sclerosis (FALS) cases. The mechanism of late-onset disease manifestation despite the innate mutation has no clear... -
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- Utility of BRAF VE1 Immunohistochemistry as a Screening Tool for Colorectal Cancer Harboring BRAF V600E Mutation
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Kwon JH, Jeong BK, Yoon YS, Yu CS, Kim J
- KMID: 2412927
- J Pathol Transl Med.
- 2018 May;52(3):157-163.
- doi: 10.4132/jptm.2018.03.28
BACKGROUND: BRAF mutation has been recognized as an important biomarker of colorectal cancer (CRC) for targeted therapy and prognosis prediction. However, sequencing for every CRC case is not cost-effective. An... -
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- Functional Identification of Compound Heterozygous Mutations in the CYP17A1 Gene Resulting in Combined 17α-Hydroxylase/17,20-Lyase Deficiency
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Mo EY, Lee JY, Kim SY, Kim MJ, Kim ES, Lee S, Han JH, Moon SD
- KMID: 2447032
- Endocrinol Metab.
- 2018 Sep;33(3):413-422.
- doi: 10.3803/EnM.2018.33.3.413
BACKGROUND: We previously reported a patient with congenital adrenal hyperplasia (CAH) with compound heterozygous mutations in the cytochrome P450 17A1 (CYP17A1) gene. One allele had a p.His373Leu and the other... -
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- Altered Retinoblastoma Protein Expression and Proliferative Activity in Urethane Induced Mouse Lung Tumorigenesis
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Chung JH, Jang JJ, Lee MJ, Ham EK
- KMID: 1804464
- Cancer Res Treat.
- 2002 Aug;34(4):258-263.
Lung cancer develops through a multistage process involving the accumulation of diverse genetic alterations. To gain an understanding of the roles played by tumor suppressor gene proteins and proliferating cell... -
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- A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation
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Chung SH, Kim SK, Kim JK, Yang YR, Suh PG, Chang JS
- KMID: 946654
- Exp Mol Med.
- 2010 Mar;42(3):216-222.
- doi: 10.3858/emm.2010.42.3.023
Growth factor stimulation induces Y783 phosphorylation of phosphoinositide-specific PLC-gamma1, and the subsequent activation of this enzyme in a cellular signaling cascade. Previously, we showed that a double point mutation, Y509A/F510A,... -
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- Correlation of p53 Protein Overexpression, Gene Mutation with Prognosis in Resected Non-Small Cell Lung Cancer(NSCLC) Patients
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No authors listed
- KMID: 2160362
- Tuberc Respir Dis.
- 1994 Aug;41(4):339-353.
- doi: 10.4046/trd.1994.41.4.339
BACKGROUND: The p53 gene codes for a DNA-bidding nuclear phosphoprotein that appears to inhibit the progression of cells from the G1 to the S phase of the cell cycle. Mutations... -
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- Cysteine-179 of I kappa B kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines
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Byun MS, Choi J, Jue DM
- KMID: 1098089
- Exp Mol Med.
- 2006 Oct;38(5):546-552.
I kappa B kinase beta (IKK beta) subunit of IKK complex is essential for the activation of NF-kappa B in response to various proinflammatory signals. Cys-179 in the activation loop... -
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- The p53 Mutation and DNA Ploidy in Human Metastatic Breast Cancer
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Cho SJ, Kim AR, Won NH
- KMID: 1725216
- Korean J Pathol.
- 1997 Feb;31(2):135-144.
The p53 gene, one of the tumor suppressor genes, is believed to play an important role through mutation and overexpression in the progression of various human malignant tumors. To compare... -
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- Clinical Significance of Plasma p53 Protein Level in Acute Leukemia
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Oh EJ, Kim Y, Han K, Kim BK, Shim SI
- KMID: 2083379
- Korean J Hematol.
- 1999 May;34(2):297-305.
BACKGROUND: Mutation in the p53 gene occurs frequently in a wide spectrum of human malignancies and the mutant protein may prove to be a useful diagnostic or prognostic marker for... -
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- p53 Protein Overexpression and p53 Mutations in Invasive Breast Carcinomas Comparison to lymph node status, DNA ploidy and histologic grade
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Shin JH, Pae WK, Kim CS, Kang YG, Lee D, Won NH
- KMID: 1940347
- J Korean Surg Soc.
- 1998 May;54(5):621-630.
Functional loss of the tumor suppressor gene p53 is one of the most frequently detected and diffusely distributed findings among human cancers. Their mutant protein products or point mutations can... -
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