- Generation and Evaluation of High beta-Glucan Producing Mutant Strains of Sparassis crispa
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Kim SR, Kang HW, Ro HS
- KMID: 1964231
- Mycobiology.
- 2013 Sep;41(3):159-163.
- doi: 10.5941/MYCO.2013.41.3.159
A chemical mutagenesis technique was employed for development of mutant strains of Sparassis crispa targeting the shortened cultivation time and the high beta-glucan content. The homogenized mycelial fragments of S.... -
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- Fungal Strain Improvement for Cellulase Production Using Repeated and Sequential Mutagenesis
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Vu VH, Pham TA, Kim K
- KMID: 2053026
- Mycobiology.
- 2009 Dec;37(4):267-271.
- doi: 10.4489/MYCO.2009.37.4.267
A fungal strain producing a high level of cellulase was selected from 320 fungal isolates and identified as Aspergillus sp. This strain was further improved for cellulase production by sequential... -
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- Breeding of New Strains of Mushroom by Basidiospore Chemical Mutagenesis
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Lee J, Kang HW, Kim SW, Lee CY, Ro HS
- KMID: 2312653
- Mycobiology.
- 2011 Dec;39(4):272-277.
Chemical mutagenesis of basidiospores of Hypsizygus marmoreus generated new mushroom strains. The basidospores were treated with methanesulfonate methylester, an alkylating agent, to yield 400 mutant monokaryotic mycelia. Twenty fast-growing mycelia... -
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- Identification of Genes Related to Fungicide Resistance in Fusarium fujikuroi
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Choi Y, Jung B, Li T, Lee J
- KMID: 2385658
- Mycobiology.
- 2017 Jun;45(2):101-104.
- doi: 10.5941/MYCO.2017.45.2.101
We identified two genes related to fungicide resistance in Fusarium fujikuroi through random mutagenesis. Targeted gene deletions showed that survival factor 1 deletion resulted in higher sensitivity to fungicides, while... -
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- Characteristics of Double Fungicide Resistant Strains of Venturia inaequalis
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Vijaya Palani P, Lalithakumari D
- KMID: 2052933
- Mycobiology.
- 2000 Jun;28(2):70-75.
Penconazole-resistant and cabendazim-resistant mutants of Venturiu inaequalis were developed by chemical (MNNG) mutagenesis. Protoplasts of these mutants were isolated and fused using polyethylene glycol as the fusogen. Fusants were classified... -
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- Transcriptional mutagenesis by 8-oxodG in alpha-synuclein aggregation and the pathogenesis of Parkinson's disease
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Basu S, Je G, Kim YS
- KMID: 2155433
- Exp Mol Med.
- 2015 Aug;47(8):e179.
- doi: 10.1038/emm.2015.54
Parkinson's disease (PD) is an age-related progressive neurodegenerative disease associated with selective loss of dopaminergic neurons. The characteristic hallmark of the disease is intracytoplasmic proteinacious inclusion bodies called Lewy bodies,... -
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- Site-Specific Mutagenesis in Human Cells by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives
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Moon KY
- KMID: 2127916
- Cancer Res Treat.
- 2004 Apr;36(2):151-156.
PURPOSE: 7-Bromomethylbenz[a]anthracene is a well- known mutagen and carcinogen. The aim of this study is to determine the mutagenic potency of its two major DNA adducts [N2-(benz[a]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[a]a2G) and N6-(benz[a]anthracen-7-... -
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- Genome Architecture and Its Roles in Human Copy Number Variation
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Chen L, Zhou W, Zhang L, Zhang F
- KMID: 2391488
- Genomics Inform.
- 2014 Dec;12(4):136-144.
- doi: 10.5808/GI.2014.12.4.136
Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic... -
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- Screening of Phytase Overproducing Strains in Aspergillus spp. by UV Mutagenesis
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Lee ES, Paik IK, Hahm YT
- KMID: 2312316
- Mycobiology.
- 2000 Sep;28(3):119-122.
Phytases (myo-inositol hexakisphosphate phosphohydrolase; EC 3.1.3.8) are enzymes which catalyze the hydrolisys of phytate into myo-inositol and inorganic phosphates. Phytases are found in plants and a variety of microorganisms. Aspergillus... -
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- Site-Specific Mutagenesis in Escherichia coli by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives in Double-Stranded or Gapped Plasmids
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Moon KY
- KMID: 1807225
- Cancer Res Treat.
- 2003 Feb;35(1):75-80.
PURPOSE: 7-Bromomethylbenz[alpha]anthracene is a known mutagen and carcinogen. The mutagenic potency of its two major DNA adducts, i.e., N2-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[alpha]a2G) and N6-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyadenosine (b[alpha]a6A), as well as the simpler benzylated analogs,... -
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- Asp 280 residue is important in the activity of the Escherichia coli leader peptidase
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Sung MS, Park KS
- KMID: 1029933
- Exp Mol Med.
- 1999 Jun;31(2):64-69.
Leader peptidase is a novel serine protease in Escherichia coli, which catalyzes the cleavage of amino-terminal signal sequences from exported proteins. It is an integral membrane protein containing two transmembrane segments with... -
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- Homo-dimerization of RyR1 C-terminus via charged residues in random coils or in an alpha-helix
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Lee EH, Allen PD
- KMID: 1090962
- Exp Mol Med.
- 2007 Oct;39(5):594-602.
To investigate the mechanism by which the C-terminus (4,938-5,037) of the ryanodine receptor 1 (RyR1) homo-tetramerizes, forming a functional Ca2+ -release channel, the structural requirements for the tetramerization were studied... -
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- Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor
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Rhee MH
- KMID: 1095120
- J Vet Sci.
- 2002 Sep;3(3):185-191.
Using site-directed mutagenesis technique, I have replaced serine 285 and serine 292 with the alanine, and assessed the binding of agonist and signaling such as the inhibition of adenylyl cyclase... -
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- Genome Editing Using Engineered Nucleases
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Shin JH, Kim H
- KMID: 2162812
- J Korean Orthop Res Soc.
- 2015 Dec;18(2):60-73.
- doi: 10.0000/jkors.2015.18.2.60
Genome editing is a useful research tool essentially applicable to gene therapy in the field of biotechnology, pharmaceutics and medicine. Scientists have developed three types of programmable nucleases for genome... -
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- The Efficient Transformation of Pleurotus ostreatus using REMI Method
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Joh JH, Kim BG, Chu KS, Kong WS, Yoo YB, Lee CS
- KMID: 2052977
- Mycobiology.
- 2003 Mar;31(1):32-35.
- doi: 10.4489/MYCO.2003.31.1.032
Restriction enzyme-mediated integration (REMI) was used to transform uracil auxotrophs of Pleurotus ostreatus to prototrophy. When protoplasts of Pleurotus ostreatus were treated by the reaction mixture containing 10 units of... -
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- Expression and Characterization of the Human Immunodeficiency Virus Type 1 Mutant Envelope Glycoproteins in Mammalian Cells
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Ryu JY, Park JS
- KMID: 1544250
- J Korean Soc Virol.
- 1999 Sep;29(3):183-193.
Human immunodeficiency virus type 1(HIV-1) envelope glycoprotein is synthesized as a 160KDa precursor, gp160, that is cleaved by a cellular protease to form the gp120 and gp41 subunits. Mammalian expression... -
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- Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis
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So I, Ashmole I, Soh H, Park C, Spencer P, Leyland M, Stanfield
- KMID: 2071587
- Korean J Physiol Pharmacol.
- 2003 Jun;7(3):131-142.
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or... -
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- Ahcyl2 upregulates NBCe1-B via multiple serine residues of the PEST domain-mediated association
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Park PW, Ahn JY, Yang D
- KMID: 2371061
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):433-440.
- doi: 10.4196/kjpp.2016.20.4.433
Inositol-1,4,5-triphosphate [IP3] receptors binding protein released with IP3 (IRBIT) was previously reported as an activator of NBCe1-B. Recent studies have characterized IRBIT homologue S-Adenosylhomocysteine hydrolase-like 2 (AHCYL2). AHCYL2 is highly... -
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- Functional identification of protein phosphatase 1-binding consensus residues in NBCe1-B
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Lee KP, Kim HJ, Yang D
- KMID: 2398559
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):91-99.
- doi: 10.4196/kjpp.2018.22.1.91
Protein phosphatase 1 (PP1) is involved in various signal transduction mechanisms as an extensive regulator. The PP1 catalytic subunit (PP1c) recognizes and binds to PP1-binding consensus residues (FxxR/KxR/K) in NBCe1-B.... -
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- Autoantigenic Role of Variant Thyroperoxidase
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Shong YK, Moon DH, Kim GS
- KMID: 2461605
- J Korean Soc Endocrinol.
- 1996 Mar;11(1):61-67.
Background: Thyroperoxidase(TPO) is one of the most important autoantigens in autoimmune thyroid disorders and autoantibody to TPO is found in almost every patients with various autoimmune thyroid diseases. Human TPO... -
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