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Inactivation of the Medial Prefrontal Cortex Interferes with the Expression But Not the Acquisition of Differential Fear Conditioning in Rats

Lee YK, Choi JS

The medial prefrontal cortex (mPFC) has been implicated in the processing of emotionally significant stimuli, particularly the inhibition of inappropriate responses. We examined the role of the mPFC in regulation...
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Effect of GABA on the contratility of small intestine isolated from rat

Huh JY, Kwon OC, Ha JH, Lee KY, Kim WJ

This study was designed to investigate the effect of GABA and related substances on the spontaneous contraction of rat small intestine. The rats (Sprague-Dawley), weighing 200-250g, were sacrificed by cervical...
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Intraocular Injection of Muscimol Induces Illusory Motion Reversal in Goldfish

Lee SY, Jung CS

Induced activation of the gamma-aminobutyric acidA (GABA(A)) receptor in the retina of goldfish caused the fish to rotate in the opposite direction to that of the spinning pattern during an...
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Modulatory Effect of Ammonium Carbonate on the GABAA Receptor

Ha JH, Kim WJ, Moon HK

  • KMID: 1961844
  • J Korean Child Neurol Soc.
  • 1998 Oct;6(1):39-46.
PURPOSE: This study was aimed to investigate the modulatory effect of ammonium carbonate on the GABAA receptor. METHODS: The effects of ammonium carbonate on the binding of radioligands to components...
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The Actions of Sodium Valproate in Headache model Evoked by Substance-P in rats.

Han JK, Park MK, Park KW, Lee DH

  • KMID: 1546744
  • J Korean Neurol Assoc.
  • 1998 Feb;16(1):1-7.
BACKGROUND AND PURPOSE: Valproic acid (2-propylpentanoic acid) which enhances GABA synthesis and blocks it's degradation has been useful treatment of migraine and may activate GABA receptors to modulate trigeminal nociceptive...
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Influence of the central benzodiazepinergic system on peripheral cardiovascular regulation

Koh JT, Ju JM, Shin DH, Cho HH, Choi BK, Kim JH

  • KMID: 1849836
  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):287-295.
Diazepam is known to have cardiovascular depressive effects through a combined action on benzodiazepinergic receptor and the GABA receptor-chloride ion channel complex. Moreover, it is known that barbiturates also have some cardiovascular regulatory...
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Pharmacology of Intracisternal or Intrathecal Glycine, Muscimol, and Baclofen in Strychnine-induced Thermal Hyperalgesia of Mice

Lee IO, Son JK, Lim ES, Kim YS

Glycine and gamma-aminobutyric acid (GABA) are localized and released by the same interneurons in the spinal cord. Although the effects of glycine and GABA on analgesia are well known, little...
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Natriuresis induced by intracerebroventricular diazepam in rabbits

Koh JT, Kook YJ

  • KMID: 2071535
  • Korean J Physiol Pharmacol.
  • 1998 Oct;2(5):555-563.
The renal function is under regulatory influence of central nervous system (CNS), in which various neurotransmitter and neuromodulator systems take part. However, a possible role of central GABA-benzodiazepine system on the central regulation...
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Inhibitory of γ-aminobutyric acid on the contractility of isolated rat vas deferens

Ahn KY, Kwon OC, Ha JH, Lee KY, Kim WJ

GABA is an inhibitory neurotransmitter in central nervous system and produce sedative, antianxiety and muscle relaxing effects via GABA(A) receptor or GABA(B) receptor. Recently it is known that GABA is...
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Blockade of the Subthalamo-nigral Pathway Prevents the Motor Component of Pilocarpine Induced Generalized Convulsive Seizure in Rats

Choi JY, Kim HS, Kim YI, Park SM, Lee KS, Kim BS

  • KMID: 2186048
  • J Korean Neurol Assoc.
  • 2000 Mar;18(2):192-198.
BACKGROUND: The substantia nigra pars reticulata is a critical site for the control of epileptic seizures. The potentiation of the inhibitory gamma-amino butyric acid (GABA) ergic input from the striatum...
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Morphine-induced Modulation of Nociceptive Spinal Dorsal Horn Neuronal Activities after Formalin-induced Inflammatory Pain

Park JM, Li KW, Jung SJ, Kim J, Kim SJ

  • KMID: 2285313
  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):77-86.
In this study, we examined the morphine-induced modulation of the nociceptive spinal dorsal horn neuronal activities before and after formalin-induced inflammatory pain. Intradermal injection of formalin induced time-dependent changes in...
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Effect of intrathecal glycine and related amino acids on the allodynia and hyperalgesic action of strychnine or bicuculline in mice

Lim ES, Lee IO

BACKGROUND: The intrathecal (IT) administration of glycine or GABAA receptor antagonist result in a touch evoked allodynia through disinhibition in the spinal cord. Glycine is an inhibitory neurotransmitter that appears...
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Spinal and Peripheral GABA-A and B Receptor Agonists for the Alleviation of Mechanical Hypersensitivity following Compressive Nerve Injury in the Rat

Jeon YH, Yoon DM, Nam TS, Leem JW, Paik GS

BACKGROUND: This study was conducted to investigate the roles of the spinal and peripheral gamma-aminobutyric acid (GABA)-ergic systems for the mechanical hypersensitivity produced by chronic compression of the dorsal root...
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The Effect of Neuroactive Steroids on the GAVA-Benzodiazepine Receptor Complex

Lee JB, Park HB, Lee JH, Park KG, Kim CS, Suh HS, Ha JH

  • KMID: 1554989
  • Korean J Psychopharmacol.
  • 1997 Oct;8(2):218-223.
Pregnolone[5beta-pregnan-3alpha-ol-one(5beta3alpha)] and allopregnanolone [(5alpha-pregnan-3alpha-ol-20-one(5alpha3alpha))] are neuroactive steroids that are reduced metabolites of progesterone. It was reported that Neuroactive steroids may have anxiolytic and anticonvulsant action similar to benzodiazepines and barbiturates....
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A Case of Amnesia Complicated by Poisoning of the Amanita Pantherina

Han J, Kim H, Lee W, Kwon SK, Kim HY, Lee SW, Kim YS

  • KMID: 2331442
  • J Korean Soc Emerg Med.
  • 2004 Dec;15(6):635-638.
Amanita pantherina and Amanita muscaria have been called hallucinogenic fungi. They contain ibotenic acid and muscimol. Patients may appear to be intoxicated or have apparent 'patherina-muscaria' syndrome, which is atropine-like,...
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The Mechanism on the Glutamate-evoked Release of [3H) norepinephrine in Rat Cortex Slices

Shin BS, Song DW, Lee SH, Seo MW, Kim YH

  • KMID: 2066064
  • J Korean Neurol Assoc.
  • 1996 Mar;14(1):238-250.
Glutamate Is the predominant excitatory neurotransmitter in the mammalian CNS. To elucidate the influence of glutamate on the noradrenergic neurotransmission in rat cortex, we examined the effects of agents that...
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Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABA(A)-ergic Systems in Mice

Shah VK, Choi JJ, Han JY, Lee MK, Hong JT, Oh KW

  • KMID: 2170625
  • Biomol Ther.
  • 2014 Jul;22(4):314-320.
This study was investigated to know whether pachymic acid (PA), one of the predominant triterpenoids in Poria cocos (Hoelen) has the sedative-hypnotic effects, and underlying mechanisms are mediated via gamma-aminobutyric...
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Participation of central GABAA receptors in the trigeminal processing of mechanical allodynia in rats

Kim MJ, Park YH, Yang KY, Ju JS, Bae YC, Han SK, Ahn DK

Here we investigated the central processing mechanisms of mechanical allodynia and found a direct excitatory link with low-threshold input to nociceptive neurons. Experiments were performed on male Sprague-Dawley rats weighing...
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4-Hydroxybenzaldehyde, One of Constituents from Gastrodiae Rhizoma Augments Pentobarbital-induced Sleeping Behaviors and Non-rapid Eye Movement (NREM) Sleep in Rodents

Choi JJ, Kim YS, Kwon YO, Yoo JH, Chong MS, Lee MK, Hong JT, Oh KW

In the previous experiments, we reported that ethanol extract of Gastrodiae Rhizoma, the dried tuber of Gastrodia ElataBlume (Orchidaceae) increased pentobarbital-induced sleeping behaviors. These experiments were undertaken to know whether...
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Effects of gamma-Aminobutyric Acid on Intrinsic Cholinergic Action in Exocrine Secretion of Isolated, Perfused Rat Pancreas

Park YD, Park HS, Cui ZY, Park HJ

  • KMID: 2071592
  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):169-174.
gamma-Aminobutyric acid (GABA) has been reported to enhance exocrine secretion evoked not only by secretagogues but also by intrinsic neuronal excitation in the pancreas. The pancreas contains cholinergic neurons abundantly...
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