- Inflammasomes in antiviral immunity: clues for influenza vaccine development
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Yamazaki T, Ichinohe T
- KMID: 2049091
- Clin Exp Vaccine Res.
- 2014 Jan;3(1):5-11.
- doi: 10.7774/cevr.2014.3.1.5
Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and... -
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- Role of inflammasomes in inflammatory autoimmune rheumatic diseases
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Yi YS
- KMID: 2398550
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):1-15.
- doi: 10.4196/kjpp.2018.22.1.1
Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of... -
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- Mechanisms of amino acid sensing in mTOR signaling pathway
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Kim E
- KMID: 2313379
- Nutr Res Pract.
- 2009 Mar;3(1):64-71.
Amino acids are fundamental nutrients for protein synthesis and cell growth (increase in cell size). Recently, many compelling evidences have shown that the level of amino acids is sensed by... -
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- Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation
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Choi KY, Yoo M, Han JH
- KMID: 2070274
- Exp Mol Med.
- 2015 Apr;47(4):e155.
- doi: 10.1038/emm.2014.129
The long-term storage of memory requires the finely tuned coordination of intracellular signaling with the transcriptional, translational and epigenetic regulations of gene expression. Among the epigenetic mechanisms, however, we know... -
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- Production of IL-1β and Inflammasome with Up-Regulated Expressions of NOD-Like Receptor Related Genes in Toxoplasma gondii-Infected THP-1 Macrophages
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Chu JQ, Shi G, Fan YM, Choi IW, Cha GH, Zhou Y, Lee YH, Quan JH
- KMID: 2367411
- Korean J Parasitol.
- 2016 Dec;54(6):711-717.
- doi: 10.3347/kjp.2016.54.6.711
Toxoplasma gondii is an obligate intracellular parasite that stimulates production of high levels of proinflammatory cytokines, which are important for innate immunity. NLRs, i.e., nucleotide-binding oligomerization domain (NOD)-like receptors, play... -
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- Rapamycin-Induced Abundance Changes in the Proteome of Budding Yeast
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Shin CS, Chang YJ, Lee HG, Huh WK
- KMID: 2166467
- Genomics Inform.
- 2009 Dec;7(4):203-207.
The target of rapamycin (TOR) signaling pathway conserved from yeast to human plays critical roles in regulation of eukaryotic cell growth. It has been shown that TOR pathway is involved... -
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- beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
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Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I
- KMID: 2155408
- Exp Mol Med.
- 2015 Feb;47(2):e143.
- doi: 10.1038/emm.2014.127
An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene.... -
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- CD98 activation increases surface expression and clusteringof beta 1 integrins in MCF-7 cells through FAK/Src- and cytoskeleton-independent mechanisms
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Kim SM, Hahn JH
- KMID: 756327
- Exp Mol Med.
- 2008 Jun;40(3):261-270.
- doi: 10.3858/emm.2008.40.3.261
CD98, a disulfide-linked 125-kDa heterodimeric type II transmembrane glycoprotein, regulates beta 1 integrin- mediated cell adhesion. However, the molecular mechanisms underlying CD98-mediated activation of beta 1 integrin are presently unclear.... -
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- Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons
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Kim HJ, Im W, Kim S, Kim SH, Sung JJ, Kim M, Lee KW
- KMID: 1090960
- Exp Mol Med.
- 2007 Oct;39(5):574-582.
Familial amyotrophic lateral sclerosis (fALS) is caused by mutations in Cu/Zn-superoxide dismutase (SOD1), and SOD1 aggregation and calcium toxicity are involved in neuronal death. However, the effect of altered calcium... -
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