- Splitomicin, a SIRT1 Inhibitor, Enhances Hematopoietic Differentiation of Mouse Embryonic Stem Cells
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Park JA, Park S, Park WY, Han MK, Lee Y
- KMID: 2447221
- Int J Stem Cells.
- 2019 Mar;12(1):21-30.
- doi: 10.15283/ijsc18040
BACKGROUND AND OBJECTIVES: Embryonic stem (ES) cells have pluripotent ability to differentiate into multiple tissue lineages. SIRT1 is a class III histone deacetylase which modulates chromatin remodeling, gene silencing, cell... -
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- Mitochondrial pyruvate dehydrogenase phosphatase 1 regulates the early differentiation of cardiomyocytes from mouse embryonic stem cells
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Heo HJ, Kim HK, Youm JB, Cho SW, Song IS, Lee SY, Ko TH, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2361541
- Exp Mol Med.
- 2016 Aug;48(8):e254.
- doi: 10.1038/emm.2016.70
Mitochondria are crucial for maintaining the properties of embryonic stem cells (ESCs) and for regulating their subsequent differentiation into diverse cell lineages, including cardiomyocytes. However, mitochondrial regulators that manage the... -
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- Effects of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) protein 9 system-Based Deletion of miR-451 in Mouse Embryonic Stem Cells on Their Self-Renewal and Hematopoietic Differentiation
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Kim SJ, Kim CH, An B, Ha KS, Hong SH, Kim KS
- KMID: 2377348
- Tissue Eng Regen Med.
- 2017 Apr;14(2):179-185.
- doi: 10.1007/s13770-017-0031-8
Pluripotent stem cells (PSCs) are a useful source of cells for exploring the role of genes related with early developmental processes and specific diseases due to their ability to differentiate... -
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- Determining Osteogenic Differentiation Efficacy of Pluripotent Stem Cells by Telomerase Activity
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Zhang S, Sun Y, Sui Y, Li Y, Luo Z, Xiao X, Zhou P, Wei S
- KMID: 2441266
- Tissue Eng Regen Med.
- 2018 Dec;15(6):751-760.
- doi: 10.1007/s13770-018-0138-6
BACKGROUND: Bone tissue engineering based on pluripotent stem cells (PSCs) is a new approach to deal with bone defects. Protocols have been developed to generate osteoblasts from PSCs. However, the... -
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