- Mitogen-activated Protein Kinases in Inflammation
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Manzoor Z, Koh YS
- KMID: 1434747
- J Bacteriol Virol.
- 2012 Sep;42(3):189-195.
- doi: 10.4167/jbv.2012.42.3.189
Mitogen-activated protein kinases (MAPKs) play critical regulatory roles in the production of the pro-inflammatory cytokines and downstream signaling events which lead to inflammation. Inflammation is a primarily localized and protective... -
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- Mitogen-activated Protein Kinase Signaling in Inflammation-related Carcinogenesis
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Manzoor Z, Koo JE, Koh YS
- KMID: 1737317
- J Bacteriol Virol.
- 2014 Dec;44(4):297-304.
- doi: 10.4167/jbv.2014.44.4.297
The role of mitogen-activated protein kinases (MAPKs) in regulation of inflammation is well known. MAPK family is activated by various stimuli and involved in transmitting extracellular signals to nucleus leading... -
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- Effect of kainic acid on the phosphorylation of mitogen activated protein kinases in rat hippocampus
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Won JS, Lee JK, Choi SS, Song DK, Huh SO, Kim YH, Suh HW
- KMID: 1607133
- Korean J Physiol Pharmacol.
- 2001 Dec;5(6):451-456.
In rat hippocampus, kainic acid (KA; 10 mg/kg; i.p.) increased the phosphorylated forms of ERK1/2 (p-ERK1/2) and Jun kinase1 (p-JNK1), but not p-JNK2 and p38 (p-p38). The preadministration with cycloheximide... -
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- Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys
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Awazu M
- KMID: 2377561
- Child Kidney Dis.
- 2017 Apr;21(1):1-7.
- doi: 10.3339/jkspn.2017.21.1.1
Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38)... -
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- Effect of Mild Hypothermia on the Mitogen Activated Protein Kinases in Experimental Stroke
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Han HS
- KMID: 1611345
- Korean J Physiol Pharmacol.
- 2004 Aug;8(4):187-194.
Middle cerebral artery occlusion (MCAO) results in cell death by activation of complex signal pathways for cell death and survival. Hypothermia is a robust neuroprotectant, and its effect has often... -
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- A Role of Mitogen Activated Protein Kinases and Inflammatory Responses in Gender Differences in Kidney Ischemia Injury
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Park KM, Han HJ
- KMID: 2285245
- Korean J Physiol Pharmacol.
- 2002 Jun;6(3):155-160.
It is not known whether gender differences play a role in susceptibility to ischemic acute renal failure. Thus, we examined if there were any differences in susceptibility between male and... -
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- Effects of Mycoplasma Pneumoniae on Activation of Human Eosinophilic Leukaemia EoL-1 Cells
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Kim ES, Lee KE, Yang HS, Kim KW, Park JY, Sohn MH, Kim KE
- KMID: 2314450
- Pediatr Allergy Respir Dis.
- 2007 Mar;17(1):8-16.
PURPOSE: Mycoplasma pneumoniae is a common cause of lower respiratory disease, especially in children and young adults. Several studies have suggested that respiratory infection by M. pneumoniae is associated with... -
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- Angiotensin Converting Enzyme Inhibition Modulates Mitogen Activated Protein Kinase Family Expressions in the Neonatal Rat Kidney
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Choi BM, Oh MH, Yoo KH
- KMID: 2278709
- Korean J Pediatr.
- 2004 Mar;47(3):325-331.
PURPOSE: In a developing kidney, the renin-angiotensin system(RAS) is markedly activated and is thought to play an important role in postnatal renal growth and maturation. We previously demonstrated that angiotensin... -
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- Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes
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Jeong YH, Park JS, Kim DH, Kim HS
- KMID: 2374611
- Biomol Ther.
- 2016 Nov;24(6):581-588.
- doi: 10.4062/biomolther.2016.141
Lonchocarpine is a phenylpropanoid compound isolated from Abrus precatorius that has anti-bacterial, anti-inflammatory, antiproliferative, and antiepileptic activities. In the present study, we investigated the antioxidant effects of lonchocarpine in brain... -
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- Regulatory Roles of MAPK Phosphatases in Cancer
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Low HB, Zhang Y
- KMID: 2168049
- Immune Netw.
- 2016 Apr;16(2):85-98.
- doi: 10.4110/in.2016.16.2.85
The mitogen-activated protein kinases (MAPKs) are key regulators of cell growth and survival in physiological and pathological processes. Aberrant MAPK signaling plays a critical role in the development and progression... -
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- Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Interleukin-6 Release and Expression in Primary Neonatal Cardiomyocytes
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Chae HJ, Kim HK, Lee WK, Chae SW
- KMID: 1615199
- Korean J Physiol Pharmacol.
- 2002 Dec;6(6):319-325.
The induction of interleukin-6 (IL-6) using combined proinflammatory agents (LPS/IFN-gamma or TNF-alpha/IFN-gamma) was studied in relation to p38 mitogen-activated protein kinase (MAPK) and NF-kappaB transcriptional factor in primary neonatal cardiomyocytes.... -
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- Transcription Factors in the Cellular Signaling Network as Prime Targets of Chemopreventive Phytochemicals
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Surh YJ
- KMID: 1804561
- Cancer Res Treat.
- 2004 Oct;36(5):275-286.
Accumulating evidence from epidemiologic and laboratory studies support an inverse relationship between a regular consumption of fruits and vegetables and the risk of specific cancers. Numerous phytochemicals derived from edible... -
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- Dexamethasone Inhibits Interleukin-1beta-Induced Matrix Metalloproteinase-9 Expression in Cochlear Cells
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Nam SI, Kwon TK
- KMID: 1973466
- Clin Exp Otorhinolaryngol.
- 2014 Sep;7(3):175-180.
- doi: 10.3342/ceo.2014.7.3.175
OBJECTIVES: To investigate the effect of interleukin (IL)-1beta on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1beta-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms involved. METHODS:... -
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- Role of Reactive Oxygen Species and Mitogen-activated Protein Kinases in 2, 3, 7, 8-tetrachlorodibinzo-p-dioxin-induced Fibronectin Secretion by MDCK Cells
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Yu MR, Ha H
- KMID: 2254244
- Korean J Nephrol.
- 2005 May;24(3):350-357.
BACKGROUND: 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD: dioxin) is a potent environmental toxicant that alters various cell function. Both reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPK) mediate dioxin-induced cytotoxicity.... -
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- Poly-L-Lactic Acid Increases Collagen Gene Expression and Synthesis in Cultured Dermal Fibroblast (Hs68) Through the p38 MAPK Pathway
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Kim SA, Kim HS, Jung JW, Suh SI, Ryoo YW
- KMID: 2430812
- Ann Dermatol.
- 2019 Feb;31(1):97-100.
- doi: 10.5021/ad.2019.31.1.97
No abstract available. -
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- Exposure to Cerium Oxide Nanoparticles Is Associated With Activation of Mitogen-activated Protein Kinases Signaling and Apoptosis in Rat Lungs
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Rice KM, Nalabotu S, Manne ND, Kolli MB, Nandyala G, Arvapalli , Ma JY, Blough ER
- KMID: 2381462
- J Prev Med Public Health.
- 2015 May;48(3):132-141.
- doi: 10.3961/jpmph.15.006
OBJECTIVES: With recent advances in nanoparticle manufacturing and applications, potential exposure to nanoparticles in various settings is becoming increasing likely. No investigation has yet been performed to assess whether respiratory... -
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- The role of p38 MAP kinase on RANKL regulation in mouse periodontal ligament fibroblasts
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Kim JC, Cui DZ, Kim YJ
- KMID: 1511576
- J Korean Acad Periodontol.
- 2007 Aug;37(Suppl):311-323.
- doi: 10.5051/jkape.2007.37.Suppl.311
No abstract available. -
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- Effect of Therapeutic Hypothermia on Mitogen-activated Protein Kinase Pathways in the Brain Tissue of a Swine Cardiac Arrest Model
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Kye YC, Suh GJ, Kwon WY, Kim KS, You KM
- KMID: 2358288
- J Korean Soc Emerg Med.
- 2016 Oct;27(5):464-472.
- doi: 10.0000/jksem.2016.27.5.464
PURPOSE: To investigate the change in mitogen-activated protein kinase pathways in the brain tissue after therapeutic hypothermia in the swine cardiac arrest model. METHODS: After the return of spontaneous circulation by... -
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- Impaired Expression of MAPK Is Associated with the Downregulation of TNF-alpha, IL-6, and IL-10 in Mycobacterium abscessus Lung Disease
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Sim YS, Kim SY, Kim EJ, Shin SJ, Koh WJ
- KMID: 2319798
- Tuberc Respir Dis.
- 2012 Mar;72(3):275-283.
BACKGROUND: Healthy individuals who develop nontuberculous mycobacteria (NTM) lung disease are likely to have specific susceptibility factors which can lead to a NTM infection. The aim of the present study... -
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- Molecular Mechanisms of Neutrophil Activation in Acute Lung Injury
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Yum HK
- KMID: 1877035
- Tuberc Respir Dis.
- 2002 Dec;53(6):595-611.
- doi: 10.4046/trd.2002.53.6.595
ABBREVIATIONS: Akt/PKB protein kinase B, ALI acute lung injury, ARDS acute respiratory distress syndrome, CREB C-AMP response element binding protein, ERK extracelluar signal-related kinase, fMLP fMet-Leu-Phe, G-CSF granulocyte colony-stimulating factor,... -
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