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Clinical Significance of Tissue Levels of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Gastric Cancer

Shim KN, Jung SA, Joo YH, Yoo K

No abstract available.
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Matrix Metalloproteinase Expression and Ldegrees Calization in Human Prostate Adendegrees Carcinoma: An Immunohistdegrees Chemical Study of MMP-2, -9, -3, -7

Shim JW, Lee YG, Lee TJ, Ro JY

  • KMID: 2175029
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):629-637.
No abstract available.
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Proteases are Modulated by Fascin in Oral Cancer Invasion

Lee MK, Park JH, Gi SH, Hwang YS

BACKGROUND: Cancer invasion is a critical factor for survival and prognosis of patients with cancer. Identifying and targeting factors that influence cancer invasion are an important strategy to overcome cancer....
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Intimal Hyperplasia

Yun SS

  • KMID: 1482905
  • J Korean Soc Vasc Surg.
  • 2008 Nov;24(2):148-154.
Intimal hyperplasia is a feature of the normal adaptive response of vessels to hemodynamic stresses, as well as being a characteristic of vessel injuries that are healing. Intimal hyperplasia in...
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Inorganic sulfur reduces the motility and invasion of MDA-MB-231 human breast cancer cells

Kim JJ, Ha AW, Kim HS, Kim WK

  • KMID: 2313541
  • Nutr Res Pract.
  • 2011 Oct;5(5):375-380.
This study investigated the effects of inorganic sulfur on metastasis in MDA-MB-231 human breast cancer cells. MDA-MB-231 cells were cultured in the absence or presence of various concentrations (12.5, 25,...
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tPA Helpers in the Treatment of Acute Ischemic Stroke: Are They Ready for Clinical Use?

Kim JS

Tissue plasminogen activator (tPA) is the only therapeutic agent approved to treat patients with acute ischemic stroke. The clinical benefits of tPA manifest when the agent is administered within 4.5...
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Antitumor Effects of Genipin: New and Emerging Insights from Recent Studies

Shin YS, Cho M, Park GH, Cho H, Kang H

Genipin, an aglycone derived from geniposide found in Gardenia jasminoides, is known to be an excellent natural cross-linker, strong apoptosis inducer, and antiviral agent. Although evidence suggests antiviral activity of...
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Chitin from the Extract of Cuttlebone Induces Acute Inflammation and Enhances MMP1 Expression

Lee KM, Shim H, Lee GS, Park IH, Lee OS, Lim SC, Kang TJ

  • KMID: 1502495
  • Biomol Ther.
  • 2013 May;21(3):246-250.
We previously reported that the extract from cuttlebone (CB) has wound healing effect in burned lesion of rat. In present study, the main component of CB extract was analyzed and...
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Roles of Matrix Metalloproteinases and Their Targets in Epileptogenesis and Seizures

Mizoguchi , Yamada K

  • KMID: 2171153
  • Clin Psychopharmacol Neurosci.
  • 2013 Aug;11(2):45-52.
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors, which...
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Immunohistochemical Expression of MMP-2 and MMP-9 Metalloproteinases in Melanocytic Nevi and Malignant Melanomas

Shin BS, Park MK, Choi KC, Chung BS

  • KMID: 2038615
  • Korean J Dermatol.
  • 2003 Aug;41(8):991-996.
BACKGROUND: One of the most important steps in neoplastic progression is represented by invasion of surrounding normal tissues by neoplastic cells. Enzymes such as the metalloproteinases(MMPs) are thought to be...
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Expression of adhesion molecules on CD34+ cells from steady-state bone marrow before and after mobilization and their association with the yield of CD34+ cells

Cecyn KZ, Kimura EY, Lima DM, Yamamoto M, Bordin JO, de Oliveira JSR

BACKGROUND: Cell adhesion molecules (CAMs) expressed on hematopoietic progenitor cells (HPCs), endothelial cells, and stromal cells play a pivotal role in the mobilization of CD34+ cells. Herein, we conducted a...
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Development of Squamous Cell Carcinoma from Actinic Keratosis after Ingenol Mebutate Gel Use

Choi JW, Suh DW, Lew BL, Sim WY

  • KMID: 2440728
  • Korean J Dermatol.
  • 2019 Feb;57(2):89-93.
Ingenol mebutate gel is a new short-term topical treatment approved in 2012 by the US Food and Drug Administration and its efficacy has been demonstrated in numerous studies. To report...
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Immunodetections of the Metalloproteinase (MMP-2 and MMP-9) and Tissue Inhibitor of Metalloproteinases (TIMP-2) in Prostatic Adenocarcinomas

Kim SS, Woo YJ, Huh J, Yoon H, Park JM, Kim M

  • KMID: 1906176
  • J Korean Cancer Assoc.
  • 1997 Jun;29(3):445-453.
PURPOSE: The metalloproteinases (MMP) and their inhibitors (TIMP) have been suggested to play a role in tumor invasion and metastasis. There have been some dispute on the exact role of...
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Lacunar Infarction and Small Vessel Disease: Pathology and Pathophysiology

Caplan LR

Two major vascular pathologies underlie brain damage in patients with disease of small size penetrating brain arteries and arterioles; 1) thickening of the arterial media and 2) obstruction of the...
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SP1 Mediates IFNgamma-induced TIMP-1 Transctription in C6 Astroglioma Cells

Shin JH, Kim SW, Kim ID, Lee MH, Lee JK

  • KMID: 2092892
  • Korean J Anat.
  • 2007 Jun;40(2):77-83.
Tissue inhibitors of metalloproteinases (TIMPs) comprise a family of secreted multifunctional proteins that consists of four members (TIMP-1 to TIMP-4). TIMPs are all major inhibitors of most matrix metalloproteinases (MMPs)....
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Expression of Matrix Metalloproteinases and Their Inhibitors in Squamous Cell Carcinoma of the Tonsil and Their Clinical Significance

Lee SY, Park SY, Kim SH, Choi EC

  • KMID: 2166449
  • Clin Exp Otorhinolaryngol.
  • 2011 Jun;4(2):88-94.
OBJECTIVES: To investigate expressions of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in squamous cell carcinoma of the tonsil and to correlate expression profiles with clinicopathological characteristics. METHODS: Paraffin...
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The expression of tissue inhibitors of metalloproteinase-2 (TIMP-2) in epithelial serous ovarian tumors

Kim TJ, Choi YL, Choi CH, Lee JW, Kim BG, Bae DS, Lee JH

  • KMID: 2143527
  • Korean J Gynecol Oncol.
  • 2006 Mar;17(1):54-61.
OBJECTIVE: Tissue inhibitors of metalloproteinases (TIMPs) play a key role in maintaining homeostasis of the extracellular matrix (ECM) by controlling matrix metalloproteinases (MMPs). In addition to their role in regulating...
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Expressions of MMP-2, MMP-9, TIMP-1, and TIMP-2 as prognostic factors in endometrial cancer

Choi JR, Lee TH, Oh YL, Lee CJ, Kim WG

OBJECTIVE: Homeostasis of the extracellular matrix (ECM) is maintained by the action of a specific system of proteolytic enzymes known as matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP)....
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mRNA Expression of Cytokines and Release of Metalloproteinases around Loose Cemented Total Hip Arthroplasty

Kim SY, Kyung HS, Shin HI, Choi JY, Kim MK, Kim JC

  • KMID: 2105448
  • J Korean Orthop Assoc.
  • 1998 Nov;33(6):1537-1545.
The aim of the present study was to investigate the mRNA expression of several cytokines which were not reported previously from interface tissues around loose cemented acetabulum to obtain better...
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Comparison Study between Immunohistochemical Staining and Enzyme Linked Immunosorbent Assay in Metalloproteinases and Tissue inhibitor of Metalloproteinases in Virus induced Myocarditis

Hong YM, Kim SS

  • KMID: 2207692
  • J Korean Pediatr Soc.
  • 1999 Nov;42(11):1524-1534.
PURPOSE: Most tissue disruption of extracellular matrix is mediated by extracellular proteinases. Matrix metalloproteinases(MMP) and tissue inhibitor of matrix metalloproteinases(TIMP) are associated with wound healing and repair. There has been...
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