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Role of Lubiprostone on Gastrointestinal Motility

Jun JY

  • KMID: 2326225
  • J Neurogastroenterol Motil.
  • 2013 Jul;19(3):277-278.
No abstract available.
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Pharmacotherapy in Patients with Chronic Constipation

Kim SJ, Park KS

Chronic constipation is one of the most common digestive diseases frequently observed in a clinical setting. It has been known to cause considerable damage to the quality of life of...
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Effects of Lubiprostone on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Colon

Jiao HY, Kim DH, Ki JS, Ryu KH, Choi S, Jun JY

Lubiprostone is a chloride (Cl-) channel activator derived from prostaglandin E1 and used for managing constipation. In addition, lubiprostone affects the activity of gastrointestinal smooth muscles. Interstitial cells of Cajal...
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Lubiprostone Increases Small Intestinal Smooth Muscle Contractions Through a Prostaglandin E Receptor 1 (EP1)-mediated Pathway

Chan WW, Mashimo H

  • KMID: 2326230
  • J Neurogastroenterol Motil.
  • 2013 Jul;19(3):312-318.
BACKGROUND/AIMS: Lubiprostone, a chloride channel type 2 (ClC-2) activator, was thought to treat constipation by enhancing intestinal secretion. It has been associated with increased intestinal transit and delayed gastric emptying....
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Optimal Pharmacologic Treatment of Chronic Constipation: Review and Recent Developments

Shin JE

  • KMID: 2307407
  • Korean J Neurogastroenterol Motil.
  • 2009 Dec;15(2):100-106.
Constipation is a common clinical problem that can be difficult to manage. Typical pharmacologic recommendations for patients with chronic constipation begin with bulking agents and then add osmotic agents followed...
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Abdominal Bloating: Pathophysiology and Treatment

Seo AY, Kim N, Oh DH

  • KMID: 2325764
  • J Neurogastroenterol Motil.
  • 2013 Oct;19(4):433-453.
Abdominal bloating is a very common and troublesome symptom of all ages, but it has not been fully understood to date. Bloating is usually associated with functional gastrointestinal disorders or...
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Emerging Pharmacologic Therapies for Constipation-predominant Irritable Bowel Syndrome and Chronic Constipation

Eswaran S, Guentner A, Chey WD

  • KMID: 2381166
  • J Neurogastroenterol Motil.
  • 2014 Apr;20(2):141-151.
Irritable bowel syndrome with constipation and chronic functional constipation are common digestive disorders that negatively impact quality of life and account for billions of dollars in health care costs. Related...
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New Generation Laxatives

Hong SN, Shin JE, Hong KS, Jung KW, Lee TH, Lee BE, Park SY, Kim SE, Park KS, Choi SC, Constipation Research group of the Korean Society of Neurogastroenterology and Motility

A significant proportion of chronic constipation patients are dissatisfied with their treatment. Recently, a number of new medications have been introduced for patients refractory to conventional laxatives, such as prucalopride,...
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Pharmacologic and Complementary and Alternative Medicine Therapies for Irritable Bowel Syndrome

Chey WD, Maneerattaporn M, Saad R

  • KMID: 2284205
  • Gut Liver.
  • 2011 Sep;5(3):253-266.
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by episodic abdominal pain or discomfort in association with altered bowel habits (diarrhea and/or constipation). Other gastrointestinal symptoms, such...
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