- IL-5 Promoter Polymorphism Enhances IgE Responses to Staphylococcal Superantigens in Adult Asthmatics
-
Losol P, Kim SH, Hwang EK, Shin YS, Park HS
- KMID: 2260346
- Allergy Asthma Immunol Res.
- 2013 Mar;5(2):106-109.
- doi: 10.4168/aair.2013.5.2.106
Interleukin 5 (IL-5) is a key cytokine involved in the induction of T-helper type 2 (Th2) responses in the asthmatic airway. We investigated IL-5 genetic polymorphisms associated with asthma phenotypes,... -
- CITED
-
- Close
- SHARE
-
- Close
- The Role of Upper Airway Microbiome in the Development of Adult Asthma
-
Losol P, Choi JP, Kim SH, Chang YS
- KMID: 2518344
- Immune Netw.
- 2021 Jun;21(3):e19.
- doi: 10.4110/in.2021.21.e19
Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are characterized by eosinophil and/or neutrophil cell dominant airway inflammation that represent distinct clinical features. Upper... -
- CITED
-
- Close
- SHARE
-
- Close
- Molecular Genetic Mechanisms of Chronic Urticaria
-
Losol P, Yoo HS, Park HS
- KMID: 2166923
- Allergy Asthma Immunol Res.
- 2014 Jan;6(1):13-21.
- doi: 10.4168/aair.2014.6.1.13
Chronic urticaria (CU) is a common allergic skin disease that requires long-term pharmacological treatment. Some patients with severe CU suffer a poor quality of life. Although the pathogenic mechanisms of... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytokine Inductions and Intracellular Signal Profiles by Stimulation of dsRNA and SEB in the Macrophages and Epithelial Cells
-
Choi JP, Losol P, Ayoub G, Ji M, Kim SH, Cho SH, Chang YS
- KMID: 2536242
- Immune Netw.
- 2022 Apr;22(2):e15.
- doi: 10.4110/in.2022.22.e15
Foreign molecules, including viruses and bacteria-derived toxins, can also induce airway inflammation. However, to the best of our knowledge, the roles of these molecules in the development of airway inflammation... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of Toll-like Receptor 3 Variants in Aspirin-Exacerbated Respiratory Disease
-
Palikhe NS, Kim SH, Kim JH, Losol P, Ye YM, Park HS
- KMID: 2130364
- Allergy Asthma Immunol Res.
- 2011 Apr;3(2):123-127.
- doi: 10.4168/aair.2011.3.2.123
PURPOSE: Although the mechanism of virus-induced, aspirin-exacerbated respiratory disease (AERD) is not known fully, direct activation of viral components through Toll-like receptor 3 (TLR3) has been suggested. TLR3 recognizes double-stranded... -
- CITED
-
- Close
- SHARE
-
- Close
- A genetic effect of IL-5 receptor alpha polymorphism in patients with aspirin-exacerbated respiratory disease
-
Losol P, Kim SH, Shin YS, Ye YM, Park HS
- KMID: 2154233
- Exp Mol Med.
- 2013 Mar;45(3):e14.
Persistent eosinophil activation in both the upper and lower airway mucosa is a central feature of aspirin-exacerbated respiratory disease (AERD). Eosinophil activation and survival are profoundly influenced by interleukin 5... -
- CITED
-
- Close
- SHARE
-
- Close
- Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma
-
Pham DL, Kim SH, Losol P, Yang EM, Shin YS, Ye YM, Park HS
- KMID: 2373813
- Korean J Intern Med.
- 2016 Mar;31(2):375-385.
- doi: 10.3904/kjim.2014.390
BACKGROUND/AIMS: Role of autophagy in neutrophil function and the association of autophagy and autophagy related (ATG) gene polymorphisms with asthma susceptibility were suggested. In this study, we investigated the genetic... -
- CITED
-
- Close
- SHARE
-
- Close
