- Secondary Prophylaxis of Docetaxel Induced Diarrhea with Loperamide: Case Report
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Lee HY, Lee YH, Kim MJ, Kim HK
- KMID: 1777697
- J Korean Med Sci.
- 2013 Oct;28(10):1549-1551.
- doi: 10.3346/jkms.2013.28.10.1549
Diarrhea is a common adverse event of docetaxel with 20%-40% of incidence and severe diarrhea occurs in 5%-6%. Several treatment guidelines for chemotherapy induced diarrhea (CID) exist, however the prophylaxis... -
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- Loperamide Oxide in Acute Diarrhea in Adults : A Randomized Double-Blind Placebo-controlled Multicenter Trial
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Bak YT, Lee KH, Han DS, Park JW, Kim NY, Yoon BC, Lee OY, Lim SH, Jung HJ
- KMID: 2143737
- Korean J Gastroenterol.
- 1998 May;31(5):629-638.
BACKGROUND AND AIMS: Laperarnide is an esteblished treatment regimen for acute diarrhea. The prodrug loperamide oxide is converted to loperamide by the anaerobic bacteria in the lower gastrointestinal tract. When... -
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- The Effect of Probiotic on Constipation in Rats
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Kim JH, Park SC, Kim JY, Park YK
- KMID: 1469805
- Yeungnam Univ J Med.
- 2009 Dec;26(2):102-107.
- doi: 10.12701/yujm.2009.26.2.102
BACKGROUND: Constipation is one of the most common disorders in Korea and Western countries. It may be related with life style, diet, physical activity, age, stress and gender, and particularly... -
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- Loperamide or Diazepam Improves Long-lasting Fecal Incontinence after Low Anterior Resection of the Rectum
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Kim TS, Lee SJ
- KMID: 1844422
- J Korean Surg Soc.
- 2005 Jun;68(6):498-504.
PURPOSE: Some patients who underwent low anterior resection of the rectum do not show satisfying improvement in their anorectal function despite of long-term conservative management. The aim of this prospective... -
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- Metabolomics approach to serum biomarker for loperamide-induced constipation in SD rats
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Kim JE, Lee YJ, Kwak MH, Jun G, Koh EK, Song SH, Seong JE, Kim JW, Kim KB, Kim S, Hwang DY
- KMID: 2312118
- Lab Anim Res.
- 2014 Mar;30(1):35-43.
Loperamide has long been known as an opioid-receptor agonist useful as a drug for treatment of diarrhea resulting from gastroenteritis or inflammatory bowel disease as well as to induce constipation.... -
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- Diagnosis and Treatment of Irritable Bowel Syndrome
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Choi MG
- KMID: 2340774
- J Korean Med Assoc.
- 2003 Jul;46(7):612-619.
Irritable bowel syndrome (IBS) is a common chronic, relapsing functional bowel disorder. IBS can be diagnosed according to the established series of criteria excluding organic diseases, and by institution of... -
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- Establishment of a Protocol for Determining Gastrointestinal Transit Time in Mice Using Barium and Radiopaque Markers
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Myagmarjalbuu B, Moon MJ, Heo SH, Jeong SI, Park JS, Jun JY, Jeong YY, Kang HK
- KMID: 1430043
- Korean J Radiol.
- 2013 Feb;14(1):45-50.
- doi: 10.3348/kjr.2013.14.1.45
OBJECTIVE: The purpose of this study was to establish a minimally invasive and reproducible protocol for estimating the gastrointestinal (GI) transit time in mice using barium and radiopaque markers. MATERIALS AND... -
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- Pharmacologic Agents for Chronic Diarrhea
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Lee KJ
- KMID: 2070745
- Intest Res.
- 2015 Oct;13(4):306-312.
- doi: 10.5217/ir.2015.13.4.306
Chronic diarrhea is usually associated with a number of non-infectious causes. When definitive treatment is unavailable, symptomatic drug therapy is indicated. Pharmacologic agents for chronic diarrhea include loperamide, 5-hydroxytryptamine type... -
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- Effect of dual-type oligosaccharides on constipation in loperamide-treated rats
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Han SH, Hong KB, Kim EY, Ahn SH, Suh HJ
- KMID: 2359614
- Nutr Res Pract.
- 2016 Dec;10(6):583-589.
- doi: 10.4162/nrp.2016.10.6.583
BACKGROUND/OBJECTIVES: Constipation is a condition that can result from intestinal deformation. Because humans have an upright posture, the effects of gravity can cause this shape deformation. Oligosaccharides are common prebiotics... -
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- Laxative effect of peanut sprout extract
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Seo JY, Kim SS, Kim HJ, Liu KH, Lee HY, Kim JS
- KMID: 2313678
- Nutr Res Pract.
- 2013 Aug;7(4):262-266.
Certain phenolic compounds are known to exhibit laxative properties. Seed sprouts, such as those of peanut, are known to promote de novo biosynthesis of phenolic compounds. This study was conducted... -
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- Correlation between laxative effects of uridine and suppression of ER stress in loperamide induced constipated SD rats
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Kim JE, Song BR, Yun WB, Choi JY, Park JJ, Lee MR, Hwang DY
- KMID: 2402266
- Lab Anim Res.
- 2017 Dec;33(4):298-307.
- doi: 10.5625/lar.2017.33.4.298
A correlation between endoplasmic reticulum (ER) stress and laxative effects was first reported in a constipation model treated with an aqueous extract of Liriope platyphylla (AEtLP) roots. To investigate the... -
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- Laxative effects of Liriope platyphylla are tightly correlated with suppression of endoplasmic reticulum stress in loperamide-induced constipation of SD rats
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Kim JE, Go J, Sung JE, Lee HA, Seo EJ, Yun WB, Hwang DY
- KMID: 2312150
- Lab Anim Res.
- 2016 Mar;32(1):16-23.
- doi: 10.5625/lar.2016.32.1.16
A dysfunction of endoplasmic reticulum (ER) stress response can result in various diseases, including cancer, inflammation, diabetes and neurodegenerative disorders. To investigate whether ER stress response can play an essential... -
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- Characterization the response of Korl:ICR mice to loperamide induced constipation
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Kim JE, Yun WB, Sung JE, Lee HA, Choi JY, Choi YS, Jung YS, Kim KS, Hwang DY
- KMID: 2362915
- Lab Anim Res.
- 2016 Dec;32(4):231-240.
- doi: 10.5625/lar.2016.32.4.231
Animal models of constipation induced with drugs and diet have been widely employed to investigate therapeutic effects and the action mechanism of drugs against this disease. ICR mice were selected... -
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- Drug Therapy of Irritable Bowel Syndrome
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Bak YT
- KMID: 2347604
- J Korean Med Assoc.
- 2002 May;45(5):629-637.
- doi: 10.5124/jkma.2002.45.5.629
Irritable bowel syndrome (IBS) is a chronic relapsing disorder of gastrointestinal function, the main features of which are abdominal pain or discomfort and an alteration of the bowel habit. Rome... -
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- Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
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Kim JE, Kang MJ, Choi JY, Park JJ, Lee MR, Song BR, Kim HR, Park JW, Choi HJ, Bae SJ, Hwang DY
- KMID: 2459299
- Lab Anim Res.
- 2018 Dec;34(4):223-231.
- doi: 10.5625/lar.2018.34.4.223
Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts... -
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- Chemotherapy Related Oral and Gastrointestinal Mucositis
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Park Y, Kim YH
- KMID: 1936494
- J Korean Med Assoc.
- 2009 Sep;52(9):897-906.
- doi: 10.5124/jkma.2009.52.9.897
Mucositis is the one of the most common complications during chemotherapy or radiotherapy. Once developed, mucositis influences the treatment outcome by severe pain, malnutrition, risk of infection, and prolonged hospitalization.... -
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- Fluoroscopic Characterization of Colonic Dysmotility Associated to Opioid and Cannabinoid Agonists in Conscious Rats
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DÃaz-Ruano S, López-Pérez AE, Girón R, Pérez-GarcÃa I, MartÃn-Fontelles MI, Abalo R
- KMID: 2449102
- J Neurogastroenterol Motil.
- 2019 Apr;25(2):300-315.
- doi: 10.5056/jnm18202
BACKGROUND/AIMS: Gastrointestinal adverse effects have a major impact on health and quality of life in analgesics users. Non-invasive methods to study gastrointestinal motility are of high interest. Fluoroscopy has been... -
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- Metabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats
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Kim JE, Lee YJ, Ryu SH, Park JW, Kang MJ, Choi HJ, Bae SJ, Choi Y, Kang HG, Kim KB, Kim S, Lim Y, Hwang DY
- KMID: 2470108
- Lab Anim Res.
- 2019 Aug;35(2):52-60.
- doi: 10.1186/s42826-019-0009-x
Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine and characterize putative biomarkers... -
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- Clinical Characteristics of Microscopic Colitis in Korea: Prospective Multicenter Study by KASID
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Park YS, Baek DH, Kim WH, Kim JS, Yang SK, Jung SA, Jang BI, Choi CH, Han DS, Kim YH, Chung YW, Kim SW, Kim YS
- KMID: 2135090
- Gut Liver.
- 2011 Jun;5(2):181-186.
BACKGROUND/AIMS: Microscopic colitis (MC) encompasses collagenous and lymphocytic colitis and is characterized by chronic diarrhea. In cases of MC, colonic mucosae are macroscopically normal, and diagnostic histopathological features are observed... -
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