- Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
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Koo SH
- KMID: 1705200
- Clin Mol Hepatol.
- 2013 Sep;19(3):210-215.
- doi: 10.3350/cmh.2013.19.3.210
Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the... -
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- Clinical implications of advances in liver regeneration
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Kwon YJ, Lee KG, Choi D
- KMID: 2155285
- Clin Mol Hepatol.
- 2015 Mar;21(1):7-13.
- doi: 10.3350/cmh.2015.21.1.7
Remarkable advances have been made recently in the area of liver regeneration. Even though liver regeneration after liver resection has been widely researched, new clinical applications have provided a better... -
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- Insulin Resistance in Non-Alcoholic Fatty Liver Disease
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Park JH
- KMID: 760627
- Korean J Hepatol.
- 2006 Mar;12(1):16-30.
Insulin resistance is the pathophysiological hallmark of various kinds of clinical diseases, including non- alcoholic fatty liver disease. Insulin resistance is the common characteristic of metabolic syndrome and its related... -
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- Bioelectrical Impedance May Predict Cell Viability During Ischemia and Reperfusion in Rat Liver
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Cui ML, Ahn HS, Kim JY, Shin HJ, Lee DS, Kim HJ, Yun SS
- KMID: 1792928
- J Korean Med Sci.
- 2010 Apr;25(4):577-582.
- doi: 10.3346/jkms.2010.25.4.577
Ischemia and reperfusion (I/R) injury is a major cause of hepatic failure after liver surgery, but no method could monitor or predict it real-time during surgery. We measured bioelectrical impedance... -
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- Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells
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Min G
- KMID: 994396
- Exp Mol Med.
- 2010 Nov;42(11):731-738.
- doi: 10.3858/emm.2010.42.11.074
The nuclear receptors, steroid and xenobiotic receptor (SXR) and constitutive androstane receptor (CAR) play important functions in mediating lipid and drug metabolism in the liver. The present study demonstrates modulatory... -
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- CD44 Disruption Attenuates Murine Hepatic Ischemia/Reperfusion Injury
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Kim MS, Lee KH, Lee WM, Jun JH, Kim DH
- KMID: 1094264
- J Korean Med Sci.
- 2011 Jul;26(7):919-926.
- doi: 10.3346/jkms.2011.26.7.919
Neutrophil adhesion and migration are critical in hepatic ischemia/reperfusion (I/R) injury. Despite very strong preclinical data, recent clinical trials failed to show a protective effect of anti-adhesion therapy in reperfusion... -
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- Association of Hepatic Iron Deposition and Serum Iron Indices with Hepatic Inflammation and Fibrosis Stage in Nonalcoholic Fatty Liver Disease
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Moon JH, Park SH, Oh KC, Jung JO, Shin WG, Kim JP, Kim KO, Park CH, Hahn T, Yoo KS, Kim JH, Kim DJ, Lee MS, Park CK, Jun SY
- KMID: 772970
- Korean J Gastroenterol.
- 2006 Jun;47(6):432-439.
BACKGROUND/AIMS: Nonalcoholic steatohepatitis can develop from nonalcoholic fatty liver and progress to severe liver disease such as cirrhosis. The mechanism determining the progression from fatty liver to steatohepatitis is... -
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- Hsp70 and HSF-1 expression is altered in the tissues of pigs transported for various periods of times
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Zhang M, Yue Z, Liu Z, Islam A, Rehana B, Tang S, Bao E, Hartung J
- KMID: 1389764
- J Vet Sci.
- 2012 Sep;13(3):253-259.
- doi: 10.4142/jvs.2012.13.3.253
The aim of this study was to assess changes of Hsp70 and HSF-1 protein and mRNA expression in stress-sensitive organs of pigs during transportation for various periods of time. Twenty... -
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- Simple Purification of Adeno-Associated Virus-DJ for Liver-Specific Gene Expression
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Liu J, Moon YA
- KMID: 2374103
- Yonsei Med J.
- 2016 May;57(3):790-794.
- doi: 10.3349/ymj.2016.57.3.790
Recombinant gene expression using adeno-associated viruses (AAVs) has become a valuable tool in animal studies, as they mediate safe expression of transduced genes for several months. The liver is a... -
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- Hemodynamic characteristics of extracellular UTP in the perfused rat liver
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Kong ID, Chung HS, Park KS, Han JK, Lee JW
- KMID: 2158055
- Yonsei Med J.
- 1996 Aug;37(4):262-269.
- doi: 10.3349/ymj.1996.37.4.262
Uridine 5'-triphosphate (UTP) is stored in the granules of cells such as platelets and is released into the extracellular space upon cell stimulation. Extracellular UTP is known to influence many... -
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- Activation of calcium signaling by hepatitis B virus-X protein in liver cells
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Oh JC, Jeong DL, Kim IK, Oh SH
- KMID: 1109320
- Exp Mol Med.
- 2003 Aug;35(4):301-309.
Hepatitis B virus x gene product (HBx) is known to be a transactivator of transcriptional elements that regulate the expression of a variety of genes associated with the growth, differentiation,... -
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- The Effects of Antioxidants and Nitric Oxide Modulators on Hepatic Ischemic-Reperfusion Injury in Rats
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Rhee JE, Jung SE, Shin SD, Suh GJ, Noh DY, Youn YK, Oh SK, Choe KJ
- KMID: 1109759
- J Korean Med Sci.
- 2002 Aug;17(4):502-506.
- doi: 10.3346/jkms.2002.17.4.502
Ischemic-reperfusion injury (IRI) is thought to be caused by oxygen radicals. Nitric oxide (NO) also has been thought to play a key role in IRI. This experiment was designed to... -
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- Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation
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Kim HY, Cho HK, Yoo SK, Cheong J
- KMID: 1506226
- Exp Mol Med.
- 2012 Oct;44(10):622-632.
Six transmembrane protein of prostate 2 (STAMP2) plays a key role in linking inflammatory and diet-derived signals to systemic metabolism. STAMP2 is induced by nutrients/feeding as well as by cytokines... -
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- Protein Expression Profiles in a Rat Cirrhotic Model Induced by Thioacetamide
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An JH, Seong J, Oh H, Kim W, Han KH, Paik YH
- KMID: 760634
- Korean J Hepatol.
- 2006 Mar;12(1):93-102.
BACKGROUND/AIMS: The reactive oxygen species from thioacetamide (TAA) induces rat liver cirrhosis that resembles the human disease, and it can serve as a suitable animal model for studying human... -
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- Tissue-specific activation of mitogen-activated protein kinases for expression of transthyretin by phenylalanine and its metabolite, phenylpyruvic acid
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Park JW, Lee MH, Choi JO, Park HY, Jung SC
- KMID: 983983
- Exp Mol Med.
- 2010 Feb;42(2):105-115.
- doi: 10.3858/emm.2010.42.2.012
Phenylketonuria is an autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase. Transthyretin has been implicated as an indicator of nutritional status in phenylketonuria patients. In this study, we... -
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- Insulin-dependent suppression of cholesterol 7alpha-hydroxlase is a possible link between glucose and cholesterol metabolisms
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Park WH, Pak YK
- KMID: 1123369
- Exp Mol Med.
- 2011 Oct;43(10):571-579.
- doi: 10.3858/emm.2011.43.10.064
Cholesterol 7alpha-hydroxylase (CYP7A1) regulates the balance between cholesterol supply and metabolism by catalyzing the rate-limiting step of bile acid biosynthesis. The transcriptional activity of CYP7A1 is tightly controlled by various... -
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- Antioxidant Status in Nonalcoholic Steatohepatitis
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Park KS, Jang BK, Kwon KM, Chung WJ, Cho KB, Hwang JS, Ahn SH, Mun KC, Kim YH
- KMID: 760591
- Korean J Hepatol.
- 2005 Jun;11(2):135-143.
BACKGROUND/AIMS: Nonalcoholic steatohepatitis (NASH) is chronic liver disease that can potentially progress to end stage liver disease. Oxidative stress to the vulnerable fatty liver has been reported as a... -
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- Effects of Vitamin E Supplementation on Oxidative Stress in Streptozotocin Induced Diabetic Rats: Investigation of Liver and Plasma
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Seven A, Guzel S, Seymen O, Civelek S, Bolayirli , Uncu M, Burcak G
- KMID: 721423
- Yonsei Med J.
- 2004 Aug;45(4):703-710.
- doi: 10.3349/ymj.2004.45.4.703
This experimental study was designed to investigate the effects of vitamin E supplementation, especially on lipid peroxidation and antioxidant status elements3/4namely, glutathione (GSH), CuZn superoxide dismutase (CuZn SOD), and glutathione... -
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- Cloning and expression of rat liver type glucose transporter and translocation by insulin in Chinese hamster ovary cells
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Ahn YH, Yoon DJ, Han GS, Lee BG
- KMID: 1729599
- Yonsei Med J.
- 1993 Jun;34(2):117-125.
- doi: 10.3349/ymj.1993.34.2.117
The 5'- and 3'-side half of liver type glucose transporter (GLUT2) cDNA was amplified from total RNA or mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR). The amplified 5'-side fragment of... -
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- Concurrent Low Brain and High Liver Uptake on FDG PET Are Associated with Cardiovascular Risk Factors
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Nam HY, Jun S, Pak K, Kim IJ
- KMID: 2427952
- Korean J Radiol.
- 2017 Apr;18(2):392-401.
- doi: 10.3348/kjr.2017.18.2.392
OBJECTIVE: Concurrent low brain and high liver uptake are sometimes observed on fluorine-18-labeled fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). We investigated the potential clinical significance of this uptake pattern related... -
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