- The role of nitric oxide as an effector of macrophage-mediated cytotoxicity against Trichomonas vaginalis
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Park GC, Ryu JS, Min DY
- KMID: 658271
- Korean J Parasitol.
- 1997 Sep;35(3):189-195.
- doi: 10.3347/kjp.1997.35.3.189
The purpose of this study is to determine whether nitric oxide is involved in the extracellular killing of Trichomonas vaginalis by mouse (BALB/c) peritoneal macrophages and RAW264.7 cells... -
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- Exogenous rhTRX reduces lipid accumulation under LPS-induced inflammation
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Han GY, Lee EK, Park HW, Kim HJ, Kim CW
- KMID: 2155336
- Exp Mol Med.
- 2014 Jan;46(1):e71.
- doi: 10.1038/emm.2013.136
Redox-regulating molecule, recombinant human thioredoxin (rhTRX) which shows anti-inflammatory, and anti-oxidative effects against lipopolysaccharide (LPS)-stimulated inflammation and regulate protein expression levels. LPS-induced reactive oxygen intermediates (ROI) and NO production were... -
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- Stimulation of macrophage function by S-antigen: production of nitric oxide
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Bae SR
- KMID: 754267
- Korean J Ophthalmol.
- 2000 Jun;14(1):12-19.
- doi: 10.3341/kjo.2000.14.1.12
In this study, we investigated whether retinal soluble proteins, such as S-antigen, play a role in the induction of nitric oxide by macrophages in vitro. Cells from the murine macrophage... -
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- Establishment of minimal positive-control conditions to ensure brain safety during rapid development of emergency vaccines
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Baek H, Kim KH, Park MY, Kim K, Ko B, Seo HS, Kim BS, Hahn TW, Yi SS
- KMID: 2412562
- J Vet Sci.
- 2017 Aug;18(S1):371-379.
- doi: 10.4142/jvs.2017.18.S1.371
With the increase in international human and material exchanges, contagious and infectious epidemics are occurring. One of the effective methods of epidemic inhibition is the rapid development and supply of... -
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- Acetyl salicylic acid inhibits Th17 airway inflammation via blockade of IL-6 and IL-17 positive feedback
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Moon HG, Kang CS, Choi JP, Choi DS, Choi HI, Choi YW, Jeon SG, Yoo JY, Jang MH, Gho YS, Kim YK
- KMID: 2154224
- Exp Mol Med.
- 2013 Jan;45(1):e5.
T-helper (Th)17 cell responses are important for the development of neutrophilic inflammatory disease. Recently, we found that acetyl salicylic acid (ASA) inhibited Th17 airway inflammation in an asthma mouse model... -
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- Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils
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Jung YS, Lee HY, Kim SD, Park JS, Kim JK, Suh PG, Bae YS
- KMID: 2154246
- Exp Mol Med.
- 2013 Jun;45(6):e27.
Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (beta-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils... -
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- Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes
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Kim NH, Hong BK, Choi SY, Moo Kwon H, Cho CS, Yi EC, Kim WU
- KMID: 2154251
- Exp Mol Med.
- 2013 Jul;45(7):e32.
The activation of nuclear factor of activated T cells 5 (NFAT5), a well-known osmoprotective factor, can be induced by isotonic stimuli, such as activated Toll-like receptors (TLRs). It is unclear,... -
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- The Effect of Bortezomib on Expression of Inflammatory Cytokines and Survival in a Murine Sepsis Model Induced by Cecal Ligation and Puncture
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Han SH, Kim JS, Woo JH, Jeong SJ, Shin JS, Ahn YS, Kim JM
- KMID: 2352796
- Yonsei Med J.
- 2015 Jan;56(1):112-123.
- doi: 10.3349/ymj.2015.56.1.112
PURPOSE: Although the proteasome inhibitor known as bortezomib can modulate the inflammatory process through the nuclear factor-kappa B signaling pathway, the immunomodulatory effect of pre-incubated bortezomib has not been fully... -
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- Receptor activator of NF-kappaB ligand enhances the activity of macrophages as antigen presenting cells
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Park H, Park OJ, Shin J, Choi Y
- KMID: 1116197
- Exp Mol Med.
- 2005 Dec;37(6):524-532.
Receptor activator of NFkappaB ligand (RANKL) is known as a key regulator of osteoclastogenesis. However, the fact that fibroblasts and periodontal ligament cells express RANKL in response to bacterial substances,... -
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- A novel beta-glucan produced by Paenibacillus polymyxa JB115 induces nitric oxide production in RAW264.7 macrophages
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Chang ZQ, Lee JS, Hwang MH, Hong JH, Jung HK, Lee SP, Park SC
- KMID: 1102975
- J Vet Sci.
- 2009 Jun;10(2):165-167.
- doi: 10.4142/jvs.2009.10.2.165
The effect of extracellular beta-(1-->3), (1-->6)-glucan, produced by Paenibacillus polymyxa JB115, on nitric oxide (NO) production in RAW264.7 macrophages was investigated. beta-glucan induced the production of NO by RAW264.7 macrophages... -
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- Defects in the differentiation and function of bone marrow-derived dendritic cells in non-obese diabetic mice
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Lee M, Kim AY, Kang Y
- KMID: 648127
- J Korean Med Sci.
- 2000 Apr;15(2):217-223.
- doi: 10.3346/jkms.2000.15.2.217
Due to their high immunostimulatory ability as well as the critical role they play in the maintenance of self-tolerance, dendritic cells have been implicated in the pathogenesis of autoimmune diseases.... -
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- Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts
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Park MK, Oh HJ, Heo YM, Park EM, Cho ML, Kim HY, Park SH
- KMID: 1022119
- Exp Mol Med.
- 2011 Aug;43(8):446-454.
- doi: 10.3858/emm.2011.43.8.050
Indoleamine 2,3-dioxygenase (IDO) is a key negative regulator of immune responses and has been implicated in tumor tolerance, autoimmune disease and asthma. IDO was detected in the joint synovial tissue... -
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- beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macro phages by suppressing redox-based NF-kappaB activation
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Bai SK, Lee SJ, Na HJ, Ha KS, Han JA, Lee H, Kwon YG, Chung CK, Kim YM
- KMID: 1093467
- Exp Mol Med.
- 2005 Aug;37(4):323-334.
beta-Carotene has shown antioxidant and antiinflammatory activities; however, its molecular mechanism has not been clearly defined. We examined in vitro and in vivo regulatory function of beta-carotene on the production... -
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- Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1
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Park DW, Baek K, Kim JR, Lee JJ, Ryu SH, Chin BR, Baek SH
- KMID: 1123464
- Exp Mol Med.
- 2009 Mar;41(3):171-179.
- doi: 10.3858/emm.2009.41.3.020
Resveratrol is a polyphenolic compound in red wine that has anti-oxidant and cardioprotective effects in animal models. Reactive oxygen species (ROS) and monocyte chemotactic protein-1 (MCP-1) play key roles in... -
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- Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury
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Song J, Cho KJ, Cheon SY, Kim SH, Park KA, Lee WT, Lee JE
- KMID: 2154288
- Exp Mol Med.
- 2013 Dec;45(12):e69.
Neural stem cells (NSCs) have been suggested as a groundbreaking solution for stroke patients because they have the potential for self-renewal and differentiation into neurons. The differentiation of NSCs into... -
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- Expression of dendritic cell markers on cultured neutrophils and its modulation by anti-apoptotic and pro-apoptotic compounds
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Park HY, Jin JO, Song MG, Park JI, Kwak JY
- KMID: 756066
- Exp Mol Med.
- 2007 Aug;39(4):439-449.
Neutrophils are also known to acquire the characteristics of dendritic cells (DCs) under the appropriate conditions. In this study, neutrophils were cultivated in vitro in the presence or absence of... -
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- Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of I kappa B
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Chang K, Lee SJ, Cheong I, Billiar TR, Chung HT, Han JA, Kwon YG, Ha KS, Kim YM
- KMID: 1094075
- Exp Mol Med.
- 2004 Aug;36(4):311-324.
The expression of inducible nitric oxide synthase (iNOS) is a critical factor in both normal physiological functions and the pathogenesis of disease. This study was undertaken to determine the molecular... -
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- Phagocytosis of serum-and IgG-opsonized zymos an particles induces apoptosis through superoxide but not nitric oxide in macrophage J774A.1
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Kim JS, Kwon HY, Choi WH, Jeon CY, Kim JI, Kim J, Lee JY, Kim YS, Park JB
- KMID: 1094703
- Exp Mol Med.
- 2003 Jun;35(3):211-221.
Phagocytosis of serum- and IgG-opsonized zymosan (SOZ and IOZ, respectively) particles into J774A.1 macrophages induced apoptosis of the cells, accompanied by the expression of p21(WAF1), one of cyclin-dependent protein kinase... -
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- Probiotics may Reduce Inflammation by Enhancing Peroxisome Proliferator Activated Receptor gamma Activation in HT-29 Cells
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Eun CS, Han DS, Lee SH, Jeon YC, Sohn JH, Kim YS, Lee J
- KMID: 782835
- Korean J Gastroenterol.
- 2007 Mar;49(3):139-146.
BACKGROUND/AIMS: The peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor highly expressed in the colon which plays an anti-inflammatory role through the inhibition of nuclear factor-kappaB (NF-kappaB) pathway. Probiotics... -
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- Colchicine-derived compound CT20126 promotes skin allograft survival by regulating the balance of Th1 and Th2 cytokine production
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Lee SJ, Namkoong S, Ha KS, Nam WD, Kwon YG, Lee H, Yoon EY, Chang DJ, Kim SO, Kim YM
- KMID: 1094664
- Exp Mol Med.
- 2007 Apr;39(2):230-238.
Colchicine has been shown to regulate the expression of inflammatory gene, but this compound possesses much weaker anti-inflammatory activity. In this study, we synthesized a new colchicine derivative CT20126 and... -
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