- Evaluation of Eye Irritation Potential of Solid Substance with New 3D Reconstructed Human Cornea Model, MCTT HCE(TM)
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Jang WH, Jung KM, Yang HR, Lee M, Jung HS, Lee SH, Park M, Lim KM
- KMID: 2382369
- Biomol Ther.
- 2015 Jul;23(4):379-385.
- doi: 10.4062/biomolther.2015.004
The eye irritation potential of drug candidates or pharmaceutical ingredients should be evaluated if there is a possibility of ocular exposure. Traditionally, the ocular irritation has been evaluated by the... -
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- New Anticoagulants for the Prevention and Treatment of Venous Thromboembolism
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Kim JH, Lim KM, Gwak HS
- KMID: 2389377
- Biomol Ther.
- 2017 Sep;25(5):461-470.
- doi: 10.4062/biomolther.2016.271
Anticoagulant drugs, like vitamin K antagonists and heparin, have been the mainstay for the treatment and prevention of venous thromboembolic disease for many years. Although effective if appropriately used, traditional... -
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- Ibuprofen Increases the Hepatotoxicity of Ethanol through Potentiating Oxidative Stress
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Kim M, Lee EJ, Lim KM
- KMID: 2513488
- Biomol Ther.
- 2021 Mar;29(2):205-210.
- doi: 10.4062/biomolther.2020.108
Over 30 million prescriptions of NSAIDs (non-steroidal anti-inflammatory drugs) are issued every year. Considering that these drugs are available without a prescription as over the counter (OTC) drugs, their use... -
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- Platelet Shape Changes and Cytoskeleton Dynamics as Novel Therapeutic Targets for Anti-Thrombotic Drugs
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Shin EK, Park H, Noh JY, Lim KM, Chung JH
- KMID: 2378799
- Biomol Ther.
- 2017 May;25(3):223-230.
- doi: 10.4062/biomolther.2016.138
Platelets play an essential role in hemostasis through aggregation and adhesion to vascular injury sites but their unnecessary activation can often lead to thrombotic diseases. Upon exposure to physical or... -
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- Postoperative orocutaneous fistula closure using a vacuum-assisted closure system: a case report
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Lee SJ, Kwon JI, Lim KM, Kim HJ, Cha IH, Nam W
- KMID: 2328508
- J Korean Assoc Oral Maxillofac Surg.
- 2010 Oct;36(5):413-416.
Fleischmann et al. first described the concept of using sub-atmospheric pressure to treat open or infected wounds in 1993. Since then, Argenta and Morykwas developed subatmospheric, or negative pressure dressings... -
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- Transoral removal of proximal submandibular stone: report of 5 cases and review of the literature
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Lim KM, Lee SJ, Kil TJ, Choi EJ, Kim HJ, Cha IH, Nam W
- KMID: 2328596
- J Korean Assoc Oral Maxillofac Surg.
- 2010 Dec;36(6):548-552.
The submandibular gland is the second largest major salivary gland, which secretes 40% of the total daily saliva. Owing to its anatomic characteristics as well as the high viscosity and... -
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- Antioxidative Activity of Lichen Thamnolia vermicularis in vitro
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Luo H, Ren M, Lim KM, Koh YJ, Wang LS, Hur JS
- KMID: 1598816
- Mycobiology.
- 2006 Sep;34(3):124-127.
- doi: 10.4489/MYCO.2006.34.3.124
This study was aimed at evaluating the antioxidant activities of methanol extract of Thamnolia vermicularis. The antioxidant activity, reducing power, superoxide anion radical scavenging and free radical scavenging activities were... -
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- New Record of Karoowia saxeti (Stizenb.) Hale in South Korea
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Lim KM, Yamamoto Y, Harada H, Lee YM, Koh YJ, Hur JS
- KMID: 1598823
- Mycobiology.
- 2006 Sep;34(3):148-150.
- doi: 10.4489/MYCO.2006.34.3.148
Karoowia saxeti was recorded during the lichen field expedition in southern part of Korea in 2006. The lichen was found on the rock surface along coastal line. This species was... -
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- Proarrhythmogenic Effect of the L532P and N588K KCNH2 Mutations in the Human Heart Using a 3D Electrophysiological Model
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Heikhmakhtiar AK, Abrha AT, Jeong DU, Lim KM
- KMID: 2504700
- J Korean Med Sci.
- 2020 Jul;35(29):e238.
- doi: 10.3346/jkms.2020.35.e238
Background: Atrial arrhythmia is a cardiac disorder caused by abnormal electrical signaling and transmission, which can result in atrial fibrillation and eventual death. Genetic defects in ion channels can cause... -
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- Effects of a Mentoring Program on Stress and Self-esteem for Middle School Girls of Low Income Families
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Shin YH, Lee JH, Lee SY, Lim KM, Lee S
- KMID: 2322161
- J Korean Acad Psychiatr Ment Health Nurs.
- 2012 Sep;21(3):220-228.
PURPOSE: The purpose of this study was to evaluate the effects of a mentoring program designed to help middle school girls from low income families cope with stress and improve... -
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- Urticarial Dermatitis: Clinical Characteristics of Itch and Therapeutic Response to Cyclosporine
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Kim JM, Lim KM, Kim HS, Ko HC, Kim MB, Kim BS
- KMID: 2394836
- Ann Dermatol.
- 2017 Apr;29(2):143-148.
- doi: 10.5021/ad.2017.29.2.143
BACKGROUND: Urticarial dermatitis, which is characterised by persistent wheals with eczematous papules and plaques, is frequently misdiagnosed and difficult to treat. Patients commonly experience intolerable pruritus which may greatly affect... -
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- Theoretical Estimation of Cannulation Methods for Left Ventricular Assist Device Support as a Bridge to Recovery
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Lim KM, Lee JS, Song JH, Youn CH, Choi JS, Shim EB
- KMID: 1786015
- J Korean Med Sci.
- 2011 Dec;26(12):1591-1598.
- doi: 10.3346/jkms.2011.26.12.1591
Left ventricular assist device (LVAD) support under cannulation connected from the left atrium to the aorta (LA-AA) is used as a bridge to recovery in heart failure patients because it... -
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- Modulation of Osteogenic Differentiation of Adipose-Derived Stromal Cells by Co-Treatment with 3, 4’-Dihydroxyflavone, U0126, and N-Acetyl Cysteine
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Song K, Yang GM, Han J, Gil M, Dayem AA, Kim K, Lim KM, Kang GH, Kim S, Jang SB, Vellingiri B, Cho SG
- KMID: 2532407
- Int J Stem Cells.
- 2022 Aug;15(3):334-345.
- doi: 10.15283/ijsc22044
Background and Objectives: Flavonoids form the largest group of plant phenols and have various biological and pharma-cological activities. In this study, we investigated the effect of a flavonoid, 3, 4’-dihydroxyflavone... -
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- Antaroide, a Novel Natural Nine-Membered Macrolide, Inhibits Melanin Biosynthesis in B16F10 Murine Melanoma Cells
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Ryu MJ, Baek EK, Kim S, Seong CN, Yang I, Lim KM, Nam SJ
- KMID: 2510130
- Biomol Ther.
- 2021 Jan;29(1):98-103.
- doi: 10.4062/biomolther.2020.064
Abstract The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine... -
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- Anti-Helicobacter pylori Compounds from Maackia amurensis
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Park WS, Bae JY, Kim HJ, Kim MG, Lee WK, Kang HL, Baik SC, Lim KM, Lee MK, Ahn MJ
- KMID: 2409599
- Nat Prod Sci.
- 2015 Mar;21(1):49-53.
- doi: 10.0000/nps.2015.21.1.49
Eight isoflavonoid compounds were isolated from the EtOAc fraction of Maackia amurensis which had shown the highest anti-Helicobacter pylori activity among the fractions, using medium pressure liquid chromatography and recrystallization.... -
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- Computational Quantification of the Cardiac Energy Consumption during Intra-Aortic Balloon Pumping Using a Cardiac Electromechanics Model
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Lim KM, Lee JS, Gyeong MS, Choi JS, Choi SW, Shim EB
- KMID: 2158007
- J Korean Med Sci.
- 2013 Jan;28(1):93-99.
- doi: 10.3346/jkms.2013.28.1.93
To quantify the reduction in workload during intra-aortic balloon pump (IABP) therapy, indirect parameters are used, such as the mean arterial pressure during diastole, product of heart rate and peak... -
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- Impact of High Fat Diet-induced Obesity on the Plasma Levels of Monoamine Neurotransmitters in C57BL/6 Mice
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Kim M, Bae S, Lim KM
- KMID: 2170666
- Biomol Ther.
- 2013 Nov;21(6):476-480.
Obesity is one of the most serious health problems in developed countries. It negatively affects diverse aspects of human wellbeing. Of these, a relationship between obesity and depression is widely... -
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- A New Murine Liver Fibrosis Model Induced by Polyhexamethylene Guanidine-Phosphate
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Kim M, Hur S, Kim KH, Cho Y, Kim K, Kim HR, Nam KT, Lim KM
- KMID: 2526814
- Biomol Ther.
- 2022 Mar;30(2):126-136.
- doi: 10.4062/biomolther.2021.120
Liver fibrosis is part of the wound healing process to help the liver recover from the injuries caused by various liver-damaging insults. However, liver fibrosis often progresses to life-threatening cirrhosis... -
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- Numerical Simulation of the Effect of Sodium Profile on Cardiovascular Response to Hemodialysis
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Lim KM, Choi SW, Min BG, Shim EB
- KMID: 1793193
- Yonsei Med J.
- 2008 Aug;49(4):581-591.
- doi: 10.3349/ymj.2008.49.4.581
PURPOSE: We developed a numerical model that predicts cardiovascular system response to hemodialysis, focusing on the effect of sodium profile during treatment. MATERIALS and METHODS: The model consists of a... -
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- Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices
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Ha S, Seidle T, Lim KM
- KMID: 2469680
- Environ Health Toxicol.
- 2016 ;31(1):e2016026.
- doi: 10.5620/eht.e2016026
OBJECTIVES: Korea's Act on the Registration and Evaluation of Chemicals (K-REACH) was enacted for the protection of human health and the environment in 2015. Considering that about 2000 new substances... -
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