- 3R-Refinement principles: elevating rodent well-being and research quality
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Rinwa P, Eriksson M, Cotgreave I, Bäckberg M
- KMID: 2554148
- Lab Anim Res.
- 2024 Mar;40(1):14-24.
- doi: 10.1186/s42826-024-00198-3
This review article delves into the details of the 3R-Refinement principles as a vital framework for ethically sound rodent research laboratory. It highlights the core objective of the refinement protocol,... -
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- Care, management, and use of ferrets in biomedical research
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Pramod R, Atul P, Pandey M, Anbazhagan S, Mhaske S, Barathidasan R
- KMID: 2554147
- Lab Anim Res.
- 2024 Mar;40(1):1-13.
- doi: 10.1186/s42826-024-00197-4
The ferret (Mustela putorius furo) is a small domesticated species of the family Mustelidae within the order Carnivora. The present article reviews and discusses the current state of knowledge about housing, care, breeding, and biomedical uses of ferrets. The management and breeding procedures of ferrets resemble those used... -
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- Age‑related changes in hematological and biochemical profiles of Wistar rats
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Patel S, Patel S, Kotadiya A, Patel S, Shrimali B, Joshi N, Patel T, Trivedi H, Patel J, Joharapurkar A, Jain M
- KMID: 2553465
- Lab Anim Res.
- 2024 Mar;40(1):84-95.
- doi: 10.1186/s42826-024-00194-7
Background Wistar rats are extensively used as the model for assessing toxicity and efficacy in preclinical research. Hematological and biochemical laboratory data are essential for evaluating specific variations in the physiological and functional profile of a laboratory animal. Establishing hematological and biochemical reference values... -
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- The memory ameliorating effects of novel N‑benzyl pyridine‑2‑one derivatives on scopolamine‑induced cognitive deficits in mice
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Pant S, Gupta M, Anthwal T, Chauhan M, Nain S
- KMID: 2553463
- Lab Anim Res.
- 2024 Mar;40(1):104-114.
- doi: 10.1186/s42826-023-00187-y
Background Alzheimer’s disease (AD), the most common form of progressive dementia in the elderly, is a chronic neurological disorder that decreases cognitive ability. Although the underlying cause of AD is yet unknown, oxidative stress and brain acetylcholine shortage are the key pathogenic causes. Results... -
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- Morin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways
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Verma V, Malik S, Mutneja E, Sahu A, Prajapati V, Mishra P, Bhatia J, Arya D
- KMID: 2553469
- Lab Anim Res.
- 2024 Mar;40(1):51-63.
- doi: 10.1186/s42826-024-00190-x
Background High blood glucose levels in diabetes lead to vascular inflammation which accelerates atherosclerosis. Herein, Morin was orally administered in male Wistar rats, at the dose of 40 mg/kg for 28 days, and on the 27th and 28th day, ISO was administered to designate groups... -
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- Isoflavone‑enriched soybean leaves (Glycine max) restore loss of dermal collagen fibers induced by ovariectomy in the Sprague Dawley rats
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Yoo D, Xie C, Jeong J, Park K, Kang S, Lee D
- KMID: 2553468
- Lab Anim Res.
- 2024 Mar;40(1):115-120.
- doi: 10.1186/s42826-024-00189-4
Phytoestrogens, such as isoflavones, are known for their capacity to simulate various physiological impacts of estro‑ gen in the human body. Our research evaluated the effects of isoflavone-enriched soybean leaves (IESL) on collagen fiber loss prompted by ovariectomy in Sprague Dawley... -
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- Effects of housing conditions on stress, depressive like behavior and sensory‑motor performances of C57BL/6 mice
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Abidin , Keser H, Şahin E, Öztürk H, Başoğlu H, Alver A, Aydin‑Abidin S
- KMID: 2553466
- Lab Anim Res.
- 2024 Mar;40(1):74-83.
- doi: 10.1186/s42826-024-00193-8
Background The effects of housing conditions on animal physiology, behavior or stress are still debated. The aim of this study was to investigate the effects of three different housing systems, individually... -
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- Impact of altered environment and early postnatal methamphetamine exposure on serotonin levels in the rat hippocampus during adolescence
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Čechová B, Jurčovičová J, Petríková I, Vaculín , Šandera , Šlamberová R
- KMID: 2553471
- Lab Anim Res.
- 2024 Mar;40(1):25-36.
- doi: 10.1186/s42826-024-00192-9
Background Methamphetamine (MA) is a highly abused psychostimulant across all age groups including pregnant women. Because developing brain is vulnerable by the action of drugs, or other noxious stimuli, the aim of our study was to examine the effect of early postnatal administration of MA alone... -
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- Chlorogenic acid regulates the expression of protein phosphatase 2A subunit B in the cerebral cortex of a rat stroke model and glutamate-exposed neurons
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Kang J, Son H, Park D, Jin Y, Koh P
- KMID: 2553464
- Lab Anim Res.
- 2024 Mar;40(1):96-103.
- doi: 10.1186/s42826-024-00196-5
Background Ischemic stroke is a serious neurological disorder caused by blockages in cerebral artery. Protein phosphatase 2A (PP2A) is a phosphatase that performs a critical role in cell signaling and growth. PP2A subunit B acts as a neuroprotective agent in the nerve system. Chlorogenic... -
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- In silico, anti‑inflammatory and acute toxicological evaluation of an indigenous medicinal plant Pterospermum rubiginosum using Sprague‑Dawley rats
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Anish R, Nair A, Saraswathy V, Kalpana V, Shyma R
- KMID: 2553470
- Lab Anim Res.
- 2024 Mar;40(1):37-50.
- doi: 10.1186/s42826-024-00191-w
Background Pterospermum rubiginosum has been traditionally used by the tribal inhabitants of Southern India for treating bone fractures and as a local anti-inflammatory agent; however, experimental evidence to support this traditional usage is lacking. The present study aimed to investigate... -
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- Naringin from sweet orange peel improves testicular function in high fat diet‑induced diabetic rats by modulating xanthine oxidase/ uric acid signaling and maintaining redox balance
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Okesina K, Odetayo A, Adeyemi W, Ajibare A, Okesina A, Olayaki L
- KMID: 2553467
- Lab Anim Res.
- 2024 Mar;40(1):64-73.
- doi: 10.1186/s42826-024-00188-5
Background Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting many organs, including the testis. Naringin from orange peel extract (OPE) is a flavanone with fertility-enhancing properties. Hence, this study was designed to establish the effect of naringin on T2DM-induced testicular dysfunction.... -
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