- Mycophenolic Acid Induced Apoptosis in Human Jurkat Cells viathe Generation of Reactive Oxygen Species
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Lee DK, Lee HK, Choi SJ, Chung SY
- KMID: 1476276
- J Korean Surg Soc.
- 2008 Sep;75(3):149-155.
PURPOSE: Mycophenolic acid (MPA) is the active agent of mycophenolate mofetil (MMF), which is an immunosuppressive drug. MPA is a selective inhibitor of inosine monophosphate dehydrogenase. The aim of this... -
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- CD43 cross-linking increases the Fas-induced apoptosis through induction of Fas aggregation in Jurkat T-cells
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Kim HJ, Park HJ, Park WS, Bae Y
- KMID: 1110119
- Exp Mol Med.
- 2006 Aug;38(4):357-363.
CD43 (sialophorin, leukosialin) is a heavily sialylated surface protein expressed on most leukocytes and platelets including T cells. Although CD43 antigen is known to have multiple and complex structure, exact... -
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- p53-mediated Inhibitory Mechanism on HIV-1 Tat is Likely to be Associated with Tat-Phosphorylation
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Byune HS, Lee SG, Bae YS
- KMID: 1940944
- J Korean Soc Virol.
- 1998 Mar;28(1):39-52.
HIV-1 tat, a strong transactivator, is essential for the HIV-1 replication and AIDS progression. The Tat function is markedly inhibited by human anti-oncogene p53. This work was initiated to identify... -
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- Tacrolimus (FK506) Induced Apoptotic Signal Transduction Pathway
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Jung MR, Choi SJ, Chung SY
- KMID: 2117082
- J Korean Surg Soc.
- 2007 Nov;73(5):359-365.
PURPOSE: This study examined the effects of Tacrolimus (FK506) on the expression of the apoptotic signal transduction proteins of Jurkat human T-lymphocytes. METHODS: The cell viability was examined by a... -
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- Amoebic PI3K and PKC Is Required for Jurkat T Cell Death Induced by Entamoeba histolytica
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Lee YA, Kim KA, Min A, Shin MH
- KMID: 1792196
- Korean J Parasitol.
- 2014 Aug;52(4):355-365.
- doi: 10.3347/kjp.2014.52.4.355
The enteric protozoan parasite Entamoeba histolytica is the causative agent of human amebiasis. During infection, adherence of E. histolytica through Gal/GalNAc lectin on the surface of the amoeba can induce... -
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- Actinobacillus actinomycetemcomitans Indeces Apoptosis of Jurkat Cell Line Through the Cleavage of Poly (ADP-ribose) Polymerase
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Lee SH, Seo SY, Jeong SJ, Yoo SH, Park SM, Jeong MH, Yee ST, Kim JM
- KMID: 2099299
- J Korean Soc Microbiol.
- 1998 Oct;33(5):507-519.
No abstract available. -
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- IL-12 and IL-23 Production in Toxoplasma gondii- or LPS-Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways
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Ismail HA, Kang BH, Kim JS, Lee JH, Choi IW, Cha GH, Yuk JM, Lee YH
- KMID: 2403712
- Korean J Parasitol.
- 2017 Dec;55(6):613-622.
- doi: 10.3347/kjp.2017.55.6.613
IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these... -
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- Apoptosis Gene Expression Pattern Analysis of Jurkat Cells Treated with FK506
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Jang TY, Lee JS, Woo GW, Kim HC, Lee HK, Chung SY
- KMID: 1464879
- J Korean Surg Soc.
- 2009 Oct;77(4):225-237.
- doi: 10.4174/jkss.2009.77.4.225
PURPOSE: FK506 (tacrolimus) is a widely used immunosuppressive agent in the treatment of various medical conditions, including autoimmune disease, bone marrow and organ transplantations. Previously FK506 was known to cause... -
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- MicroRNA profiling of tacrolimus-stimulated Jurkat human T lympocytes
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Lee HK, Chung SY, Na Choi SJ
- KMID: 2096706
- J Korean Surg Soc.
- 2013 Oct;85(4):161-168.
- doi: 10.4174/jkss.2013.85.4.161
PURPOSE: This study investigated the Jurkat T cell line expresses cytotoxicity when treated with different concentrations of FK506, and analyzed the expression pattern of microRNA when stimulated by FK506 using... -
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- Cytotoxic Mechanism of FK506 on Human T Lymphocytes
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Kim KY, Kim GH, Park CY, Choi SJ, Chung SY
- KMID: 2211095
- J Korean Surg Soc.
- 2007 Sep;73(3):191-197.
PURPOSE: FK506 (Tacrolimus) has been widely used as an immunosuppressant. We examined the effects of FK506 on the activation, proliferation and expression of cytotoxic effector molecules of Jurkat human T-lymphocytes.... -
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- Cytolytic activity of mitogen activated old and young mouse spleen cells against tumor target cells expressing high or low levels of Fas antigen
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Saxena RK, Adler WH
- KMID: 755042
- Exp Mol Med.
- 1999 Sep;31(3):137-141.
Sensitivity of Fas expressing tumor cells (high levels in Hut78 & Jurkat; low levels in P815) toward the cytotoxic Con-A (5 microg/ml) activated spleen cells from young (12 to 16 week old... -
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- Effects of Heme Oxygenase-1 Expression in Mycophenolic Acid Induced Apoptosis of Jurkat Cell Lines
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Lee HK, Choi SJ
- KMID: 2211964
- J Korean Surg Soc.
- 2010 Jun;78(6):343-349.
- doi: 10.4174/jkss.2010.78.6.343
PURPOSE: This study demonstrates that pharmacologic induction of heme oygenase-1 (HO-1) along with catalytic activation significantly modulated apoptosis of Jurkat cells induced by mycophenolic acid (MPA). METHODS: Cells were cultured with... -
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- Charged MVB protein 5 is involved in T-cell receptor signaling
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Wi SM, Min Y, Lee KY
- KMID: 2327679
- Exp Mol Med.
- 2016 Jan;48(1):e206.
- doi: 10.1038/emm.2015.102
Charged multivesicular body protein 5 (CHMP5) has a key role in multivesicular body biogenesis and a critical role in the downregulation of signaling pathways through receptor degradation. However, the role... -
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- The effect of cyclophosphamide on Fas-mediated apoptosis
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Lee JH, Park JH, Yang MH
- KMID: 1038387
- J Korean Med Sci.
- 1997 Jun;12(3):185-189.
- doi: 10.3346/jkms.1997.12.3.185
Fas is a cell surface protein that can mediate apoptosis and belongs to the tumor necrosis factor (TNF) receptor family. Anti-Fas antibody induces apoptotic cell death in... -
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- The Effect of FK506 to Generate Reactive Oxygen Species on T Lymphocyte Death
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Lee HK, Chung SY, Choi SJ
- KMID: 1750699
- J Korean Surg Soc.
- 2009 Nov;77(5):310-319.
- doi: 10.4174/jkss.2009.77.5.310
PURPOSE: Tacrolimus (FK506) has been widely used as an immunosuppressant in organ transplanted recipients to suppress organ rejection phenomenon. We investigated the role of oxidative stress and heme oxygense-1 by... -
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- Effect of hypertonic saline and macrophage migration inhibitory factor in restoration of T cell dysfunction
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Yoon YH, Choi SH, Hong YS, Lee SW, Moon SW, Cho HJ, Han C, Cheon YJ, Bansal V
- KMID: 1445742
- J Korean Surg Soc.
- 2011 Oct;81(4):229-234.
- doi: 10.4174/jkss.2011.81.4.229
PURPOSE: Trauma-induced suppression of cellular immune function likely contributes to sepsis, multiple organ dysfunction syndrome and death. T cell proliferation decreases after traumatic stress. The addition of prostaglandin E2 (PGE2),... -
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- Mycophenolic acid mediated mitochondrial membrane potential transition change lead to T lymphocyte apoptosis
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Choi SJ, Lee HK, Kim NH, Chung SY
- KMID: 1445743
- J Korean Surg Soc.
- 2011 Oct;81(4):235-241.
- doi: 10.4174/jkss.2011.81.4.235
PURPOSE: This study demonstrated that apoptosis induced by mycophenolic acid (MPA) is mediated by mitochondrial membrane potential transition (MPT) changes in Jurkat cells. METHODS: Cell viability and MPT changes were measured... -
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- Effects of Hydroxychloroquine on the Metabolism of Fas ligand of T cells
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Min JK, Lee HJ, Lee WS, Park SH, Min SY, Cho ML, Cho CS, Kim HY
- KMID: 2202458
- J Korean Rheum Assoc.
- 2000 Jun;7(2):127-139.
OBJECTIVE: Hydroxychloroquine (HCQ) is a drug that has been used to treat autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. However, the specific mechanism for its pharmacologic... -
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- Immunomodulatory effects of ethanol extract of germinated ice plant (Mesembryanthemum crystallinum)
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Choi JH, Jo SG, Jung SK, Park WT, Kim KY, Park YW, Park JH
- KMID: 2375270
- Lab Anim Res.
- 2017 Mar;33(1):32-39.
- doi: 10.5625/lar.2017.33.1.32
The purpose of this study was to investigate the immunomodulatory activity of ice plant (Mesembryanthemum crystallinum) extract (IPE) in vitro and in vivo. Raji (a human B cell line) and... -
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- The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells
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Kim YD, Bae YS, Park JC, Suh PG, Ryu SH
- KMID: 1457539
- Exp Mol Med.
- 2001 Dec;33(4):257-262.
His-Phe-Tyr-Leu-Pro-Met (HFYLPM) is a synthetic peptide that stimulates Jurkat T cells resulting in intracellular calcium ([Ca2+]i) increase in a pertussis toxin (PTX)-sensitive manner. We have examined the physiological role of... -
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