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And the story goes on: non-conventional dysplasia of the colorectum

Punjabi LS, Lai YN, Thomas A

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What’s new in molecular genetic pathology 2022: immune checkpoint inhibitor biomarkers and select solid tumors

Tsang PC, Chen G

Predictive biomarker testing plays a critical role in targeted immuno-oncology, including the use of immune checkpoint inhibitors (ICI) for various solid tumors. Molecular advancements in cancers of the breast, kidney...
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Renal cell carcinoma concomitant with multiple myeloma

Narwal A, Ramteke P, Kumar L, Mallick S

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Recurrent malignant solitary fibrous tumor of the scalp: a case report and literature review

Rabie A, Hasan A, Mohammed Y, Abdelmaksoud A, Rabaan AA

Solitary fibrous tumor (SFT) is a rare type of mesenchymal neoplasm that first was discovered in the pleura but can also affect the peritoneum, lungs, mediastinum, and skin. Cutaneous malignant...
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An unusual case of microsatellite instability–high/deficient mismatch repair (MSI-H/dMMR) diffuse large B-cell lymphoma revealed by targeted gene sequencing

Han B, Kim S, Koh J, Bae JM, Yun H, Jeon YK

Microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR) status has been approved as a tissue-agnostic biomarker for immune checkpoint inhibitor therapy in patients with solid tumors. We report the case of an MSI-H/dMMR...
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Extremely well-differentiated adenocarcinoma of the stomach: diagnostic pitfalls in endoscopic biopsy

Lee J, Lee IS, Ahn JY, Park YS, Kim J

Background: Extremely well-differentiated adenocarcinoma (EWDA) is a deceptively bland-looking adenocarcinoma of the stomach. It often causes diagnostic problems, especially in endoscopic biopsy samples. To better recognize this deceptively bland lesion,...
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Colorectal adenocarcinoma with enteroblastic differentiation: diagnostic challenges of a rare case encountered in clinical practice

Abada E, Anaya IC, Abada O, Lebbos A, Beydoun R

Colorectal adenocarcinoma with enteroblastic differentiation (CAED) is a rare subtype of colonic adenocarcinoma characterized by increased α-fetoprotein (AFP) production and the expression of at least one enteroblastic marker including AFP,...
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Blocking Toll-like receptor 9 attenuates bleomycin-induced pulmonary injury

Alzahrani B, Gaballa MMS, Tantawy AA, Moussa MA, Shoulah SA, Elshafae SM

Background: Acute respiratory distress syndrome (ARDS) is one of the most common complications in coronavirus disease 2019 patients suffering from acute lung injury (ALI). In ARDS, marked distortion of pulmonary...
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Fatty acid synthetase expression in triple-negative breast cancer

Park JH, Han HS, Lim SD, Kim WY, Park KS, Yoo YB, Lee SE, Kim WS

Background: Triple-negative breast cancer (TNBC) has a relatively poor prognosis. Research has identified potential metabolic targets, including fatty acid metabolism, in TNBC. The absence of effective target therapies for TNBC...
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