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Ischemic postconditioning may not influence early brain injury induced by focal cerebral ischemia/reperfusion in rats

Kim YK, Leem JG, Shin JW, Joung KW

BACKGROUND: Experimental studies have shown that ischemic postconditioning can reduce neuronal injury in the setting of cerebral ischemia, but the mechanisms are not yet clearly elucidated. This study was conducted...
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Protective effect of ischemic postconditioning against hepatic ischemic reperfusion injury in rat liver

Yoon SY, Kim CY, Han HJ, Lee KO, Song TJ

PURPOSE: The efficiency of ischemic postconditioning (IPC) was evaluated in a rat model of ischemic liver. Concentration of survivin of liver tissue correlated with the degree of antiapoptosis, so survivin...
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Morphine and remifentanil-induced cardioprotection: its experimental and clinical outcomes

Kim JM, Jang YH, Kim J

During the past few decades, a large number of animal studies demonstrated that commonly used opioids could provide cardioprotection against ischemia-reperfusion (I/R) injury. Opioid-induced preconditioning or postconditioning mimics ischemic preconditioning...
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Diverse Ischemic Postconditioning Protocols Affect the Infarction Size in Focal Ischemic Stroke

Lee JS, Song DJ, Hong JH, Kim TS, Joo SP

OBJECTIVE: Ischemic postconditioning (IPostC), consisted of transient brain ischemia/reperfusion cycles, is considered to have neuroprotective effect. However, there is no best single protocol of IPostC, because varied factors like species...
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The Effects of Ischemic Postconditioning on Myocardial Function and Nitric Oxide Metabolites Following Ischemia-Reperfusion in Hyperthyroid Rats

Zaman J, Jeddi S, Ghasemi A

Ischemic postconditioning (IPost) could decrease ischemia-reperfusion (IR) injury. It has not yet reported whether IPost is useful when ischemic heart disease is accompanied with co-morbidities like hyperthyroidism. The aim of...
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Ischemic Postconditioning Inhibits Mitochondrial Permeability Transition Pore via Opioid Receptor Activation in Intact Rat Heart

Lee YC, Jang YH, Kim JM, Kim AR, Lee SR, Kim YN, Hong JH

BACKGROUND: Ischemic postconditioning (Post-C), brief cycles of myocardial ischemia and reperfusion during the early phase of reperfusion, is considered as a novel adjunct strategy to protect myocardium.However, the exact mechanism...
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Cardioprotective Effect of the SDF-1α/CXCR4 Axis in Ischemic Postconditioning in Isolated Rat Hearts

Kim JS, Jang Y, Kim JH, Park YH, Hwang SA, Kim J, Lee SR, Xu Z, Ban C, Ahn K, Chun KJ

BACKGROUND AND OBJECTIVES: Information about the role of the stromal cell-derived factor-1α (SDF-1α)/chemokine receptor type 4 (CXCR4) axis in ischemic postconditioning (IPOC) is currently limited. We hypothesized that the SDF-1α/CXCR4...
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Morphine-induced postconditioning modulates mitochondrial permeability transition pore opening via delta-1 opioid receptors activation in isolated rat hearts

Kim JH, Chun KJ, Park YH, Kim J, Kim JS, Jang YH, Lee MY, Park JH

BACKGROUND: It is generally accepted that morphine affords cardioprotection against ischemia/reperfusion injury. Inhibition of the mitochondrial permeability transition pore (MPTP) is considered an end target for cardioprotection. The aim of...
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Effect of isoflurane post-treatment on tPA-exaggerated brain injury in a rat ischemic stroke model

Kim EJ, Kim SY, Lee JH, Kim JM, Kim JS, Byun JI, Koo BN

BACKGROUND: Intravenous tissue-type plasminogen activator (tPA) is recognized as the standard treatment for ischemic stroke. However, its narrow therapeutic window and association with an increased risk of intracranial hemorrhage have...
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AT1 Receptor Modulator Attenuates the Hypercholesterolemia-Induced Impairment of the Myocardial Ischemic Post-Conditioning Benefits

Li YW, Li YM, Hon Y, Wan QL, He RL, Wang ZZ, Zhao CH

BACKGROUND AND OBJECTIVES: Ischemic post-conditioning (PostC) has been demonstrated as a novel strategy to harness nature's protection against myocardial ischemia-reperfusion (I/R). Hypercholesterolemia (HC) has been reported to block the effect...
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