- Paradoxical Roles of Pancreatic Beta Cell Stimulators with Respect to Insulin Secretion and Its Morphological Changes in the Beta Cell
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Jeong IK, Kim KW
- KMID: 1569018
- J Korean Diabetes Assoc.
- 2002 Feb;26(1):1-15.
No abstract available. -
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- Induced Differentiation of Embryonic Stem Cells to Insulin Secreting Cells
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Sung JH, Lim CK, Choi HW, Lee HS, Shin H, Jun JH, Yoon HS, Koong MK
- KMID: 2235677
- Korean J Fertil Steril.
- 2004 Dec;31(4):209-216.
OBJECTIVE: Embryonic stem (ES) cells could be differentiated into the specific cell types by alternation of culture condition and modification of gene expression. This study was performed to evaluate the... -
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- Pancreatic alpha-Cell Dysfunction in Type 2 Diabetes: Old Kids on the Block
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Moon JS, Won KC
- KMID: 2280650
- Diabetes Metab J.
- 2015 Feb;39(1):1-9.
- doi: 10.4093/dmj.2015.39.1.1
Type 2 diabetes (T2D) has been known as 'bi-hormonal disorder' since decades ago, the role of glucagon from alpha-cell has languished whereas beta-cell taking center stage. Recently, numerous findings indicate... -
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- Autophagy in Diabetes
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Jung HS, Lee MS
- KMID: 2298049
- Korean Diabetes J.
- 2009 Dec;33(6):453-457.
- doi: 10.4093/kdj.2009.33.6.453
Diabetes mellitus is characterized by decreased insulin secretion and action. Decreased insulin secretion results from a reduction in mass and/or function of pancreatic beta-cells. Apoptosis, oxidative stress, mitochondrial dysfunction, and... -
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- Cell Replacement and Regeneration Therapy for Diabetes
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Jun HS
- KMID: 2222380
- Korean Diabetes J.
- 2010 Apr;34(2):77-83.
- doi: 10.4093/kdj.2010.34.2.77
Reduction of beta cell function and a beta cell mass is observed in both type 1 and type 2 diabetes. Therefore, restoration of this deficiency might be a therapeutic option... -
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- Pathophysiology of Type 2 Diabetes in Koreans
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Kwak SH, Park KS
- KMID: 2407116
- Endocrinol Metab.
- 2018 Mar;33(1):9-16.
- doi: 10.3803/EnM.2018.33.1.9
The pathophysiology of type 2 diabetes is characterized by variable degrees of insulin resistance and impaired insulin secretion. Both genetic and environmental factors serve as etiologic factors. Recent genetic studies... -
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- Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic beta cells
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Ma WN, Park SY, Han JS
- KMID: 1078361
- Exp Mol Med.
- 2010 Jun;42(6):456-464.
- doi: 10.3858/emm.2010.42.6.047
As glucose is known to induce insulin secretion in pancreatic beta cells, this study investigated the role of a phospholipase D (PLD)-related signaling pathway in insulin secretion caused by high... -
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- Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic beta-cells
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Quan W, Lim YM, Lee MS
- KMID: 1120126
- Exp Mol Med.
- 2012 Feb;44(2):81-88.
- doi: 10.3858/emm.2012.44.2.030
Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic beta-cells producing insulin. Autophagy plays a crucial role in cellular homeostasis through degradation and recycling of organelles... -
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- Latent Autoimmune Diabetes in Adults: A Review on Clinical Implications and Management
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Pieralice , Pozzilli P
- KMID: 2449621
- Diabetes Metab J.
- 2018 Dec;42(6):451-464.
- doi: 10.4093/dmj.2018.0190
Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by a less intensive autoimmune process and a broad clinical phenotype compared to classical type 1 diabetes mellitus (T1DM),... -
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- The Roles of Clusterin on Morphogenesis of Beta Cells During Pancreas Regeneration
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Hong SW, Ranjan K, Lee S, Shin YJ, Min BH, Park IS
- KMID: 2008091
- J Korean Diabetes Assoc.
- 2007 Jan;31(1):1-8.
- doi: 10.4093/jkda.2007.31.1.1
Clusterin is a highly glycosylated heterodimeric glycoprotein that plays diverse biological roles in various organs. The secreted clusterin has been established as a major form of the protein that exerts... -
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- Decreased Expression and Induced Nucleocytoplasmic Translocation of Pancreatic and Duodenal Homeobox 1 in INS-1 Cells Exposed to High Glucose and Palmitate
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Ryu GR, Yoo JM, Lee E, Ko SH, Ahn YB, Song KH
- KMID: 2281494
- Diabetes Metab J.
- 2011 Feb;35(1):65-71.
- doi: 10.4093/dmj.2011.35.1.65
BACKGROUND: Type 2 diabetes mellitus (T2DM) is often accompanied by increased levels of circulating fatty acid. Elevations in fatty acids and glucose for prolonged periods of time have been suggested... -
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- Role of Glucocorticoid Receptor on Insulin Secretion and Synthesis in INS-1 Cells
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Yang JY, Kang MS, Song TH, Jeong IK, Seo PJ, Kim HJ
- KMID: 2331791
- J Korean Diabetes Assoc.
- 2006 Nov;30(6):428-434.
BACKGROUND: Glucocorticoids play important roles in the regulation of glucose homeostasis. It is well known that glucocorticoids reduce hepatic and peripheral tissue sensitivity to insulin, but the roles of glucocorticoids... -
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- Oxidative Stress and Cell Dysfunction in Diabetes: Role of ROS Produced by Mitochondria and NAD(P)H Oxidase
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Kim SS, Son SM
- KMID: 2298076
- Korean Diabetes J.
- 2008 Oct;32(5):389-398.
- doi: 10.4093/kdj.2008.32.5.389
Oxidative stress has been considered to be a major contributor to the pathogenesis of the diabetic macrovascular and microvascular complications. In the absence of an appropriate antioxidant defense mechanism, increased... -
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- Prevention of Diabetes Using Adenoviral Mediated Hepatocyte Growth Factor Gene Transfer in Mice
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Lee HJ, Kim HJ, Roh MS, Lee JI, Lee SW, Jung DS, Kim DK, Park MK
- KMID: 1517042
- Korean J Physiol Pharmacol.
- 2003 Oct;7(5):261-266.
Type 1 diabetes is an organ-specific autoimmune disease caused by the cytotoxic T cells-mediated destruction of the insulin-producing beta cells in the Langerhans pancreatic islets. Hepatocyte growth factor (HGF) is... -
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- Defective Mitochondrial Function and Motility Due to Mitofusin 1 Overexpression in Insulin Secreting Cells
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Park KS, Wiederkehr A, Wollheim C
- KMID: 2285443
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):71-77.
- doi: 10.4196/kjpp.2012.16.1.71
Mitochondrial dynamics and distribution is critical for their role in bioenergetics and cell survival. We investigated the consequence of altered fission/fusion on mitochondrial function and motility in INS-1E rat clonal... -
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- Effect of Intracellular ATP on Zn2+ Blockade of KATP Channels in Pancreatic Beta Cells
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Song DK, Bae JH, Hong YS, Park WK
- KMID: 2298571
- Korean J Aerosp Environ Med.
- 1999 Mar;9(1):60-65.
In the therapeutic or the nutritional aspects, Zn2+ has been used as a supplement in a variety of drugs. Most of divalent or trivalent cations affect ion channels in the... -
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- In Vitro Effect of Fatty Acids Identified in the Plasma of Obese Adolescents on the Function of Pancreatic β-Cells
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Velasquez , Vasquez JS, Balcazar N
- KMID: 2392471
- Diabetes Metab J.
- 2017 Aug;41(4):303-315.
- doi: 10.4093/dmj.2017.41.4.303
BACKGROUND: The increase in circulating free fatty acid (FFA) levels is a major factor that induces malfunction in pancreatic β-cells. We evaluated the effect of FFAs reconstituted according to the... -
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- Activin A Converts Pancreatic Ductal Cells into Insulin-Secreting Cells
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Lee KH, Park MK, Kang HW, Kim HJ, Jeong IK, Yoo HJ, Jeong JH, Min YK, Lee MS, Kim KW, Lee MK
- KMID: 2008137
- J Korean Diabetes Assoc.
- 2004 Feb;28(1):20-27.
BACKGROUND: Islet transplantation as a potential treatment for diabetes has been investigated extensively over the past years. One of the major limitations to successful islet transplantation is shortage of insulin-producing... -
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- Retinoic Acid-induced Differentiation of Rat Mesenchymal Stem Cells into beta-Cell Lineage
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Kim JH, Kim KS, Lee SW, Kim HW, Joo DJ, Kim YS, Suh H
- KMID: 2202584
- J Korean Soc Transplant.
- 2015 Sep;29(3):118-129.
- doi: 10.4285/jkstn.2015.29.3.118
BACKGROUNDS: Type I diabetes mellitus (T1DM), an autoimmune disease, is associated with insulin deficiency due to the death of beta-cells. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are capable of tissue... -
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- The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36
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Yoon JS, Moon JS, Kim YW, Won KC, Lee HW
- KMID: 2363693
- J Korean Med Sci.
- 2016 Apr;31(4):547-552.
- doi: 10.3346/jkms.2016.31.4.547
Inhibition of CD36, a fatty acid transporter, has been reported to prevent glucotoxicity and ameliorate high glucose induced beta cell dysfunction. Ezetimibe is a selective cholesterol absorption inhibitor that blocks... -
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