- Inflammasomes in antiviral immunity: clues for influenza vaccine development
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Yamazaki T, Ichinohe T
- KMID: 2049091
- Clin Exp Vaccine Res.
- 2014 Jan;3(1):5-11.
- doi: 10.7774/cevr.2014.3.1.5
Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it has become increasingly evident that both DNA and... -
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- Role of inflammasomes in inflammatory autoimmune rheumatic diseases
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Yi YS
- KMID: 2398550
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):1-15.
- doi: 10.4196/kjpp.2018.22.1.1
Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of... -
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- Role of Innate Immunity in Diabetes and Metabolism: Recent Progress in the Study of Inflammasomes
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Lee MS
- KMID: 2150696
- Immune Netw.
- 2011 Apr;11(2):95-99.
- doi: 10.4110/in.2011.11.2.95
Type 1 diabetes is one of the classical examples of organ- specific autoimmune diseases characterized by lymphocytic infiltration or inflammation in pancreatic islets called 'insulitis'. In contrast, type 2 diabetes... -
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- Regulatory Roles of the Caspase-11 Non-Canonical Inflammasome in Inflammatory Diseases
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Yi YS
- KMID: 2429833
- Immune Netw.
- 2018 Dec;18(6):e41.
- doi: 10.4110/in.2018.18.e41
Inflammation is an immune response mediated by innate immune cells of tissues, against invading microbes and cellular stress. The hallmark of inflammatory responses is the activation of inflammasomes — multiprotein... -
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- Inflammasome as a Therapeutic Target for Cancer Prevention and Treatment
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Thi HT, Hong S
- KMID: 2400769
- J Cancer Prev.
- 2017 Jun;22(2):62-73.
- doi: 10.15430/JCP.2017.22.2.62
Chronic inflammation is a critical modulator of carcinogenesis through secretion of inflammatory cytokines, which leads to the formation of an inflammatory microenvironment. In this process, the inflammasome plays an important... -
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- NLRP6 as a Negative Regulator of Innate Immunity
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Manzoor Z, Koh YS
- KMID: 1782704
- J Bacteriol Virol.
- 2013 Mar;43(1):64-66.
- doi: 10.4167/jbv.2013.43.1.64
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) play important role in immune responses by regulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), type I interferon and inflammasomes. Nod-like receptor... -
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- PKR as a Regulator of Inflammasome Activation
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Manzoor Z, Koh YS
- KMID: 2168684
- J Bacteriol Virol.
- 2013 Jun;43(2):145-147.
- doi: 10.4167/jbv.2013.43.2.145
Detection of pathogen by pattern recognition receptors leads to activation of inflammasome which plays a crucial role in immune system. The inflammasome regulates the release of cytokines, such as interleukin... -
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- Pathogenic Role of Autophagy in Rheumatic Diseases
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Choi YJ, Yoo WH
- KMID: 2352464
- J Rheum Dis.
- 2016 Aug;23(4):202-211.
- doi: 10.4078/jrd.2016.23.4.202
Autophagy is a principle catabolic process mediated by lysosomes in eukaryotic cells. This is an intracellular homeostatic mechanism crucial for degradation in acidic lysosomal compartments of waste components from the... -
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- The Relationship between Mitochondria and NLRP3 Inflammasome
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Lee HA, Na HS, Chung J
- KMID: 2394576
- Int J Oral Biol.
- 2017 Sep;42(3):85-90.
- doi: 10.11620/IJOB.2017.42.3.085
Mitochondria participate in various intracellular metabolic pathways such as generating intracellular ATP, synthesizing several essential molecules, regulating calcium homeostasis, and producing the cell's reactive oxygen species (ROS). Emerging studies have... -
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- Expression of Inflammasome Complex Following Various Oral Bacterial Infection in THP-1 Cells
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Na HS, Kim SM, Song YR, Kim S, Chung J
- KMID: 2368588
- Int J Oral Biol.
- 2016 Dec;41(4):237-242.
- doi: 10.11620/IJOB.2016.41.4.237
Interleukin-1b (IL-1β), a proinflammatory cytokine, regulates the innate immune responses against bacterial infection. Mature IL-1β is produced from pro-IL-1β by activated caspase-1, which in turn is activated by the inflammasome... -
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- Functional and Mechanistic Integration of Infection and the Metabolic Syndrome
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Sommer P, Sweeney G
- KMID: 2222379
- Korean Diabetes J.
- 2010 Apr;34(2):71-76.
- doi: 10.4093/kdj.2010.34.2.71
The metabolic syndrome refers to a well defined group of risk factors, including central obesity and inflammation, for the development of diabetes and cardiovascular disease. Interestingly, many studies have recently... -
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- The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases
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Yang CS, Shin DM, Jo EK
- KMID: 2172999
- Int Neurourol J.
- 2012 Mar;16(1):2-12.
Among a number of innate receptors, the nucleotide-binding domain leucine-rich repeat containing (NLR) nucleotide oligomerization domain (NOD)-like receptor families are involved in the recognition of cytosolic pathogen- or danger-associated molecules.... -
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- Regulation of Cellular Antiviral Signaling by Modifications of Ubiquitin and Ubiquitin-like Molecules
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Li K, Zhong B
- KMID: 2404889
- Immune Netw.
- 2018 Feb;18(1):e4.
- doi: 10.4110/in.2018.18.e4
The initiation of cellular antiviral signaling depends on host pattern-recognition receptors (PRRs)-mediated recognition of viral nucleic acids that are known as classical pathogen-associated molecular patterns (PAMPs). PRRs recruit adaptor proteins... -
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- Human Immunity Against Campylobacter Infection
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Hameed A
- KMID: 2466608
- Immune Netw.
- 2019 Dec;19(6):e38.
- doi: 10.4110/in.2019.19.e38
Campylobacter is a worldwide foodborne pathogen, associated with human gastroenteritis. The efficient translocation of Campylobacter and its ability to secrete toxins into host cells are the 2 key features of... -
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- Flavonoids: Broad Spectrum Agents on Chronic Inflammation
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Lim H, Heo MY, Kim HP
- KMID: 2447851
- Biomol Ther.
- 2019 May;27(3):241-253.
- doi: 10.4062/biomolther.2019.034
Flavonoids are major plant constituents with numerous biological/pharmacological actions both in vitro and in vivo. Of these actions, their anti-inflammatory action is prominent. They can regulate transcription of many proinflammatory... -
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- Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2 Diabetes
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Lee MS
- KMID: 2129596
- J Korean Med Sci.
- 2014 Aug;29(8):1038-1041.
- doi: 10.3346/jkms.2014.29.8.1038
The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important... -
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- Pyrin Domain (PYD)-containing Inflammasome in Innate Immunity
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Hong S, Park S, Yu JW
- KMID: 1449888
- J Bacteriol Virol.
- 2011 Sep;41(3):133-146.
- doi: 10.4167/jbv.2011.41.3.133
Inflammasome is a cytosolic multiprotein complex to activate caspase-1 leading to the subsequent processing of inactive pro-interleukin-1-beta (Pro-IL-1beta) into its active interleukin-1 beta (IL-1beta) in response to pathogen- or danger-associated... -
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- Role of inflammasome activation in development and exacerbation of asthma
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Lee TH, Song HJ, Park CS
- KMID: 2397099
- Asia Pac Allergy.
- 2014 Oct;4(4):187-196.
- doi: 10.5415/apallergy.2014.4.4.187
Human airways contact with pathogen-associated molecular patterns and danger-associated molecular patterns present in many environments. Asthmatic's airways may be more susceptible to these patterns and lead to inflammasome activation; however,... -
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- The Progression of Liver Fibrosis in Non-alcoholic Fatty Liver Disease
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Kim MY
- KMID: 2384360
- Korean J Gastroenterol.
- 2017 Jun;69(6):341-347.
- doi: 10.4166/kjg.2017.69.6.341
Understanding the pathogenesis of non-alcoholic steatohepatitis (NASH) and its fibrosis progression is still evolving. Nonetheless, current evidence suggests that mechanisms involved are very complex parallel processes with multiple metabolic factors.... -
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- Inflammasomes, multi-cellular protein complex in myeloid cells, induce several metabolic diseases via interleukin-1beta maturation
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Lee GS
- KMID: 1703511
- J Biomed Res.
- 2013 Dec;14(4):195-200.
Inflammation mainly mediated by innate immune cells as the first line of host defense against pathogens is an acute response that limits tissue damage and eliminates pathogens in the body.... -
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