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WNKs: protein kinases with a unique kinase domain

Huang CL, Cha SK, Wang HR, Xie J, Cobb MH

  • KMID: 1090959
  • Exp Mol Med.
  • 2007 Oct;39(5):565-573.
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in...
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Effect of IOP elevation on matrix metalloproteinase-2 in rabbit anterior chamber

Kim CY, Kim SS, Koh HJ, You YS, Seong GJ, Hong YJ

To investigate changes in the level of matrix metalloproteinase-2 (MMP-2) in the anterior chamber of rabbit with intraocular pressure (IOP) elevation. The IOP was elevated with scleral encircling in 12...
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Differentially-altered vascular guanylate cyclase isoforms in experimental hypertensive rats

Lee JU, Kang DG, Kook H, Kim IK, Oh BS

Pathophysiological implications of the vascular nitric oxide (NO)/cGMP pathway were investigated in various rat models of hypertension. The expression of brain and endothelial constitutive NO synthases (bNOS, ecNOS) was determined...
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Altered renal expression of nitric oxide synthase isozymes in spontaneously hypertensive rats

Kim SW, Moon KH, Lee SC, Kim NH, Kang DG, Lee JU, Choi KC, Kang YJ

  • KMID: 759080
  • Korean J Intern Med.
  • 1999 Jan;14(1):21-26.
OBJECTIVES: The present study was aimed at exploring whether the pathogenesis of hypertension is related with an altered expression of nitric oxide synthase (NOS) isozymes, i.e., bNOS, iNOS...
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HMG-CoA Reductase Inhibitor Improves Endothelial Dysfunction in Spontaneous Hypertensive Rats Via Down-regulation of Caveolin-1 and Activation of Endothelial Nitric Oxide Synthase

Suh JW, Choi DJ, Chang HJ, Cho YS, Youn TJ, Chae IH, Kim KI, Kim CH, Kim HS, Oh BH, Park YB

Hypertension is associated with endothelial dysfunction and increased cardiovascular risk. Caveolin-1 regulates nitric oxide (NO) signaling by modulating endothelial nitric oxide synthase (eNOS). The purpose of this study was to...
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