- HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases
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Yoon S, Eom GH
- KMID: 2152651
- Chonnam Med J.
- 2016 Jan;52(1):1-11.
- doi: 10.4068/cmj.2016.52.1.1
Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also post-transcriptional modifiers that regulate the protein acetylation implicated in... -
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- Epigenetic Modifications: Novel Therapeutic Approach for Thyroid Cancer
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Zhu X, Cheng SY
- KMID: 2389812
- Endocrinol Metab.
- 2017 Sep;32(3):326-331.
- doi: 10.3803/EnM.2017.32.3.326
The incidence of thyroid cancer is growing the fastest among all cancers in the United States, especially in women. The number of patients with thyroid neoplasm is part of an... -
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- New Promising Therapeutic Modalities for Thyroid Cancers: Histone Deacetylase Inhibitor, PPAR-gamma Agonist, and Retinoic Acid
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Chung WY, Clark OH
- KMID: 2375954
- Korean J Endocr Surg.
- 2005 Dec;5(2):69-74.
- doi: 10.16956/kjes.2005.5.2.69
Most patients with thyroid cancer have well differentiated tumors that usually respond to conventional therapy including total or near total thyroidectomy, radioiodine ablation and TSH suppression. About 10% of patients,... -
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- IL-4 and HDAC Inhibitors Suppress Cyclooxygenase-2 Expression in Human Follicular Dendritic Cells
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Cho W, Hong SH, Choe J
- KMID: 1431929
- Immune Netw.
- 2013 Apr;13(2):75-79.
- doi: 10.4110/in.2013.13.2.75
Evidence for immunoregulatory roles of prostaglandins (PGs) is accumulating. Since our observation of PG production by human follicular dendritic cells (FDCs), we investigated the regulatory mechanism of PG production in... -
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- Apoptotic Effect of Combination Treatment with a Proteasome Inhibitor, Lactacystin, and a Histone Deacetylase Inhibitor, Trichostatin A, on MCF-7 Cells
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Kim GC, Shin YJ, Kim IR, Lee MH, Hwang YS, Gil YG, Park BS
- KMID: 1510218
- Korean J Anat.
- 2006 Dec;39(6):443-452.
Although much information has been accumulated about the synergistic interaction of proteasome inhibitors and HDAC inhibitors to induce apoptosis in a certain type of cells, much less is known currently... -
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- Sequence-Dependent Radiosensitization of Histone Deacetylase Inhibitors Trichostatin A and SK-7041
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Kim JH, Kim IH, Shin JH, Kim HJ, Kim IA
- KMID: 2167644
- Cancer Res Treat.
- 2013 Dec;45(4):334-342.
PURPOSE: This preclinical study is to determine whether the capacity of histone deacetylase (HDAC) inhibitors to enhance radiation response depends on temporal sequences of HDAC inhibition and irradiation. MATERIALS AND METHODS:... -
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- Activation of ATM-dependent DNA Damage Signal Pathway by a Histone Deacetylase Inhibitor, Trichostatin A
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Lee JS
- KMID: 1522935
- Cancer Res Treat.
- 2007 Sep;39(3):125-130.
PURPOSE: Ataxia-telangiectasia mutated (ATM) kinase regulates diverse cellular DNA damage responses, including genome surveillance, cell growth, and gene expression. While the role of histone acetylation/deacetylation in gene expression is well... -
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- Role of histone deacetylase activity in the developing lateral line neuromast of zebrafish larvae
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He Y, Mei H, Yu H, Sun S, Ni W, Li H
- KMID: 2155359
- Exp Mol Med.
- 2014 May;46(5):e94.
- doi: 10.1038/emm.2014.18
Histone deacetylases are involved in many biological processes and have roles in regulating cell behaviors such as cell cycle entry, cell proliferation and apoptosis. However, the effect of histone deacetylases... -
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- Effects of Histone Deacetylase Inhibitor (Valproic Acid) on the Expression of Hypoxia-inducible Factor-1 Alpha in Human Retinal Müller Cells
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Kim YJ, Park SJ, Kim NR, Chin HS
- KMID: 2368682
- Korean J Ophthalmol.
- 2017 Feb;31(1):80-85.
- doi: 10.3341/kjo.2017.31.1.80
PURPOSE: To evaluate the effects of valproic acid (VPA), a histone deacetylase inhibitor (HDACI), on the expression of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in human... -
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- Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
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Park S, Park JA, Jeon JH, Lee Y
- KMID: 2456216
- Biomol Ther.
- 2019 Sep;27(5):423-434.
- doi: 10.4062/biomolther.2019.051
HSP90 is a molecular chaperone that increases the stability of client proteins. Cancer cells show higher HSP90 expression than normal cells because many client proteins play an important role in... -
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- Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
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Min SK, Koh YH, Park Y, Kim HJ, Seo J, Park HR, Cho SJ, Kim IS
- KMID: 2011982
- Korean J Pathol.
- 2012 Apr;46(2):142-150.
BACKGROUND: It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma. METHODS:... -
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- Effect of Valproic acid, a Histone Deacetylase Inhibitor, on the Expression of Pluripotency and Neural Crest Specific Marker Genes in Murine Multipotent Skin Precursor Cells
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Hong J, Park SK, Roh S
- KMID: 1457215
- Int J Oral Biol.
- 2010 Dec;35(4):209-214.
Cells that have endogenous multipotent properties can be used as a starting source for the generation of induced pluripotent cells (iPSC). In addition, small molecules associated with epigenetic reprogramming are... -
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- Trichostatin A, a Histone Deacetylase Inhibitor, Potentiated Cytotoxic Effect of Ionizing Radiation in Human Head and Neck Cancer Cell Lines
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Kim JH, Shin JH, Chie EK, Wu HG, Kim JS, Kim IH, Ha SW, Park CI, Kang WS
- KMID: 2323831
- J Korean Soc Ther Radiol Oncol.
- 2004 Jun;22(2):138-144.
PURPOSE: We have previously reported that human glioblastoma cells are sensitized to radiation-induced death after their exposure to trichostatin A (TSA), a histone deacetylase inhibitor (HDAC-I), prior to the... -
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- New drugs in hematological disorders
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Park JS, Jeong SH
- KMID: 2259130
- Korean J Med.
- 2010 May;78(5):540-551.
Modern medical oncology has introduced various anti-cancer drugs since the World War I and II. Unlike for the solid tumors, hematological malignancies had been documented some limitations for curing it... -
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- A Novel Osteogenic Activity of Suberoylanilide Hydroxamic Acid is Synergized by BMP-2
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Lee ZH, Kim HJ, Ryoo HM
- KMID: 2170088
- J Bone Metab.
- 2015 May;22(2):51-56.
- doi: 10.11005/jbm.2015.22.2.51
BACKGROUND: Many histone deacetylase (HDAC) inhibitors are well recognized as potential anti-cancer drugs. Inhibition of HDACs induces temporal transcription or epigenetic control, thus regulating many different biological responses. Here, we... -
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- The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells
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Jin KL, Park JY, Noh EJ, Hoe KL, Lee JH, Kim JH, Nam JH
- KMID: 2173551
- J Gynecol Oncol.
- 2010 Dec;21(4):262-268.
- doi: 10.3802/jgo.2010.21.4.262
OBJECTIVE: To investigate the combined effects of cisplatin and the histone deacetylase (HDAC) inhibitors suberoylanilide hydroxamic acid (SAHA) or sirtinol on HeLa cells and assess the mechanism underlying HDAC inhibitor-cisplatin... -
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- Effects of Trichostatin A on the Chondrogenesis from Human Mesenchymal Stem Cells
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Lee J, Im GI
- KMID: 2394974
- Tissue Eng Regen Med.
- 2017 Aug;14(4):403-410.
- doi: 10.1007/s13770-017-0041-6
Histone deacetylase inhibitors (HDACi) are a class of compounds that suppress the function of histone deacetylases (HDACs). This study was performed to examine the effects of Trichostatin A (TSA), a... -
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- Recovery of Genes Epigenetically Altered by the Histone Deacetylase Inhibitor Scriptaid and Demethylating Agent 5-Azacytidine in Human Leukemia Cells
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Park E, Jeon E, Kim IH, Park S
- KMID: 1806201
- Genomics Inform.
- 2010 Dec;8(4):185-193.
Histone deacetylation and demethylation are epigenetic mechanisms implicated in cancer. Studies regarding the role of modulation of gene expression utilizing the histone deacetylase inhibitor scriptaid and the demethylating agent 5-azacytidine... -
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- Anti-Cancer Effect of 3-(4-dimethylamino phenyl)-N-hydroxy-2-propenamide in MCF-7 Human Breast Cancer
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Min KN, Joung KE, Kim DK, Sheen YY
- KMID: 2380177
- Environ Health Toxicol.
- 2012 ;27(1):e2012010.
OBJECTIVES: In recent years, a number of structurally diverse Histone deacetylase (HDAC) inhibitors have been identified and these HDAC inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in... -
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- Induction of growth inhibition and apoptosis in human endometrial cancer cells by histone deacetylase inhibitors
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Lim SY, Choi JK, Shin SJ, Kwon SH, Cho CH, Cha SD, Song DK
- KMID: 2273759
- Korean J Obstet Gynecol.
- 2009 Sep;52(9):911-919.
OBJECTIVE: Endometrial cancer is the most common malignant tumor of the female genital tract. Its incidence has increased in recent years, making up 13% of female genital cancers. Nevertheless, the... -
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