- Osteoinduction Using Recombinant Bone Morphogenetic Protein-7 Gene
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Jang WS, Kim JR, Sohn WJ, Seo JS, Ahn MW, Jang YS, Kim HK, Kim JR
- KMID: 2399131
- J Korean Orthop Assoc.
- 2004 Oct;39(6):598-606.
PURPOSE: The aim of this study was to develop recombinant human Bone Morphogenetic Protein-7 (BMP7)-stable cells and recombinant human BMP7 adenoviruses (AdBMP7) for osteoinduction and osteoregeneration in musculoskeletal diseases. MATERIALS... -
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- Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IkappaBalpha in TNFalpha-stimulated HEK293 cells
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Lee Y, Choi J, Ha KH, Jue DM
- KMID: 1387362
- Exp Mol Med.
- 2012 Aug;44(8):513-520.
During ischemia-reperfusion injury, brief pre-exposure to oxidative stress renders organs resistant to subsequent severe damage. NF-kappaB is a transcription factor that is involved in reperfusion-induced inflammatory and immune responses. The... -
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- TRPM7 Is Essential for RANKL-Induced Osteoclastogenesis
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Yang YM, Jung HH, Lee SJ, Choi HJ, Kim MS, Shin DM
- KMID: 1432765
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):65-71.
- doi: 10.4196/kjpp.2013.17.1.65
The transient receptor potential melastatin type 7 (TRPM7) channel is a widely expressed non-selective cation channel with fusion to the C-terminal alpha kinase domain and regarded as a key regulator... -
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- Eugenol Inhibits ATP-induced P2X Currents in Trigeminal Ganglion Neurons
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Li HY, Lee BK, Kim JS, Jung SJ, Oh SB
- KMID: 2285358
- Korean J Physiol Pharmacol.
- 2008 Dec;12(6):315-321.
- doi: 10.4196/kjpp.2008.12.6.315
Eugenol is widely used in dentistry to relieve pain. We have recently demonstrated voltage-gated Na+ and Ca2+ channels as molecular targets for its analgesic effects, and hypothesized that eugenol acts... -
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- Activation of DDR2 Involved in Atherosclerosis by Oxidative Stress
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Yang K, Yang BS
- KMID: 2015171
- J Korean Geriatr Soc.
- 2007 Dec;11(4):181-188.
BACKGROUND: Reactive Oxygen species have been known to be a key factor to promote atherosclerosis. DDR2(Discoidin Domain Receptor 2) is a cell surface receptor tyrosine kinase which is activated... -
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- Modulation of Telomerase Activity and Human Telomerase Reverse Transcriptase Expression by Caspases and Bcl-2 Family Proteins in Cisplatin-Induced Cell Death
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Park YP, Choi SC, Cho MY, Song EY, Kim JW, Paik SG, Kim YK, Kim JW, Lee HG
- KMID: 2238837
- Korean J Lab Med.
- 2006 Aug;26(4):287-293.
- doi: 10.3343/kjlm.2006.26.4.287
BACKGROUND: Human telomerase is a ribonucleoprotein polymerase, which synthesizes telomeric repeat sequences, and human telomerase reverse transcriptase (hTERT) has been identified as the catalytic subunit, as well as the rate-limiting... -
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- Role of a 19S Proteasome Subunit- PSMD10(Gankyrin) in Neurogenesis of Human Neural Progenitor Cells
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Sahu I, Nanaware P, Mane M, Mulla SW, Roy S, Venkatraman P
- KMID: 2465887
- Int J Stem Cells.
- 2019 Nov;12(3):463-473.
- doi: 10.15283/ijsc19007
PSMD10(Gankyrin), a proteasome assembly chaperone, is a widely known oncoprotein which aspects many hall mark properties of cancer. However, except proteasome assembly chaperon function its role in normal cell function... -
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- Effects of glucosamine on Ca2+ signaling and K+ channel currents in T lymphocytes
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Suh EY, Pang B, Kim SJ, Kim WK
- KMID: 1458431
- Korean J Med.
- 2010 Nov;79(5):536-542.
BACKGROUND/AIMS: Glucosamine is widely taken as a functional food, and some studies reported its anti-inflammatory effects. K+ channels and intracellular signal play important roles in the activation of immune cells... -
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- Wide Spectrum of Inhibitory Effects of Sertraline on Cardiac Ion Channels
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Lee HA, Kim KS, Hyun SA, Park SG, Kim SJ
- KMID: 1493965
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):327-332.
- doi: 10.4196/kjpp.2012.16.5.327
Sertraline is a commonly used antidepressant of the selective serotonin reuptake inhibitors (SSRIs) class. In these experiments, we have used the whole cell patch clamp technique to examine the effects... -
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- (E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone displays suppression of inflammatory responses via inhibition of Src, Syk, and NF-kappaB
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Kim Y, Jeong EJ, Han Lee IS, Kim MY, Cho JY
- KMID: 2150478
- Korean J Physiol Pharmacol.
- 2016 Jan;20(1):91-99.
- doi: 10.4196/kjpp.2016.20.1.91
(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone (MPP) is an aldol condensation product resulting from pyrrole-2-carbaldehyde and m- and p- substituted acetophenones. However, its biological activity has not yet been evaluated. Since it has been reported... -
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- Characterization of the Rho GTPase-Activating Protein RhoGAP68F
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Nahm M, Lee S
- KMID: 2165343
- Exp Neurobiol.
- 2011 Mar;20(1):29-34.
- doi: 10.5607/en.2011.20.1.29
Rho small GTPases control multiple aspects of neuronal morphogenesis by regulating the assembly and organization of the actin cytoskeleton. Although they are negatively regulated by GTPase activating proteins (GAPs), the... -
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- Increases in Doxorubicin Sensitivity and Radioiodide Uptake by Transfecting shMDR and Sodium/Iodide Symporter Gene in Cancer Cells Expressing Multidrug Resistance
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Ahn SJ, Lee YJ, Lee YL, Choi CI, Lee SW, Yoo J, Ahn BC, Lee IK, Lee J
- KMID: 1518943
- Nucl Med Mol Imaging.
- 2007 Jun;41(3):209-217.
PURPOSE: Multidrug resistance (MDR) of the cancer cells related to mdr1 gene expression can be effectively treated by selective short hairpin RNA for mdr1 gene (shMDR). Sodium/iodide symporter (NIS) gene... -
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- Production of TNF-alpha and IL-6 in Macrophages by Mycobacterial Protein Antigens
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Ahn HJ, Cho SN, Paik TH, Lee J, Choi IH
- KMID: 2150624
- Immune Netw.
- 2007 Mar;7(1):26-30.
- doi: 10.4110/in.2007.7.1.26
BACKGROUND: Mycobacterial antigens released as PIM, LM, LAM, lipoproteins and other cellular factors may contribute to macrophage and dendritic cell activation through pattern recognition receptors such as TLRs. In... -
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- CKD-712, (S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-kappaB Activation and Augments Akt Activation during TLR4 Signaling
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Lee J, Yang EJ, Shin JS, Kim DH, Lee SS, Choi IH
- KMID: 2150730
- Immune Netw.
- 2011 Dec;11(6):420-423.
- doi: 10.4110/in.2011.11.6.420
Since CKD-712 has been developed as an anti-inflammatory agent, we examined the effect of CKD-712 during TLR4 signaling. Using HEK293 cells expressing TLR4, CKD-712 was pre-treated 1 hr before LPS... -
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- Onion peel extract and its constituent, quercetin inhibits human Slo3 in a pH and calcium dependent manner
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Wijerathne TD, Kim JH, Kim MJ, Kim CY, Chae MR, Lee SW, Lee KP
- KMID: 2455814
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):381-392.
- doi: 10.4196/kjpp.2019.23.5.381
Sperm function and male fertility are closely related to pH dependent K⺠current (KSper) in human sperm, which is most likely composed of Slo3 and its auxiliary subunit leucine-rich repeat-containing... -
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- Functional Defect of the Fas Mutants Detected in Gastric Cancers
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Park WS, Cho YG, Kim CJ, Park CH, Kim YS, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY
- KMID: 2372731
- J Korean Gastric Cancer Assoc.
- 2003 Dec;3(4):186-190.
PURPOSE: The balance between cell proliferation and apoptosis is crucial for homeostatic maintenance in a cell population. Decreased apoptosis or uncontrolled proliferation can lead to cancer. The Fas receptor signal... -
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- The Role of Foxo3 in Leydig Cells
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Choi YS, Song JE, Kong BS, Hong JW, Novelli S, Lee EJ
- KMID: 2345887
- Yonsei Med J.
- 2015 Nov;56(6):1590-1596.
- doi: 10.3349/ymj.2015.56.6.1590
PURPOSE: Foxo3 in female reproduction has been reported to regulate proliferation of granulose cells that form follicles. There are no reports so far that discuss on the role of Foxo3... -
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- Construction of hNGF-betarecombinant adenovirus and screening of its expression after transfection into various cell lines
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Gao EF, Chung HJ, Ahn KM, Kim YT, Park HJ, Sung MA, Kim NY, Yoo SB, Myoung H, Hwang SJ, Kim MJ, Kim SM, Jang JW, Lee JH
- KMID: 2005033
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2005 Sep;27(5):446-456.
Nerve growth factor(NGF) has a critical role in peripheral nerve regeneration. The aim of this study is to construct a well-functioning hNGF-betarecombinat adenovirus for the ultimate development of improved method... -
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- Hydroquinone suppresses IFN-β expression by targeting AKT/IRF3 pathway
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Kim Y, Kim HG, Han SY, Jeong D, Yang WS, Kim JI, Kim JH, Yi YS, Cho JY
- KMID: 2388699
- Korean J Physiol Pharmacol.
- 2017 Sep;21(5):547-554.
- doi: 10.4196/kjpp.2017.21.5.547
Previous studies have demonstrated the role of hydroquinone (HQ), a hydroxylated benzene metabolite, in modulating various immune responses; however, its role in macrophage-mediated inflammatory responses is not fully understood. In... -
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- The Production Mechanism of TNF-alpha and IL-6 by Group IIA Phospholipase A2
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Ahn JH, Park DW, Kim JH, Bae JJ, Bae YK, Park YK
- KMID: 2320216
- Yeungnam Univ J Med.
- 2004 Dec;21(2):177-190.
BACKGROUND: Secretory phospholipase A2 (sPLA2) are a group of extracellular enzymes that release fatty acids at the sn-2 position of phospholipids. Group IIA sPLA2 (sPLA2-IIA) has been detected in the... -
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