- Role of GTP - binding Protein in Signal Transduction
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Cha BY
- KMID: 2461507
- J Korean Soc Endocrinol.
- 1994 Sep;9(3):163-179.
No abstract available. -
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- cGAS-cGAMP Signaling and Antiviral Defense
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Manzoor Z, Koh YS
- KMID: 2135365
- J Bacteriol Virol.
- 2014 Mar;44(1):112-114.
- doi: 10.4167/jbv.2014.44.1.112
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that plays an important role in innate immunity. Transfection of DNA or DNA virus infection results in the... -
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- Anti-Tumor Effect of AG60 against Ehrlich Tumor
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Lee KY, Yoo BI, Yoon JS, Chung YS, Han YB
- KMID: 2095361
- J Korean Surg Soc.
- 1998 Jun;54(6):765-771.
BACKGROUND: AG60 is a complex of acriflavine and guanosine. Our previous study revealed that AG60 had not only in vitro antitumor activities in several human cancer cell lines, but also... -
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- Metabolic loading of guanosine induces chondrocyte apoptosis via the Fas pathway
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Kim DJ, Chung JH, Ryu EK, Rhim JH, Ryu YS, Park SH, Kim KT, Kang HS, Chung HK, Park SC
- KMID: 1110124
- Exp Mol Med.
- 2006 Aug;38(4):401-407.
Although the apoptosis of chondrocytes plays an important role in endochondral ossification, its mechanism has not been elucidated. In this study, we show that guanosine induces chondrocyte apoptosis based on... -
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- The Protective Effect of Mannitol and Methylprednisolone in the Acute Focal Cerebral Ischemia in Cats
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Shin KM
- KMID: 2170822
- Ewha Med J.
- 1988 Dec;11(4):283-297.
- doi: 10.12771/emj.1988.11.4.283
It is the purpose of the this experimental study to investigate the protective effect of pretreatment of mannitol and methylprednisolone(MP) on the changes of the high-energy metabolites(nucleotides ; derivatives of... -
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- Role of Cyclic GMP-AMP Synthase in Sensing Human Immunodeficiency Virus
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Park YS, Kim IH, Koh YS
- KMID: 2168696
- J Bacteriol Virol.
- 2014 Jun;44(2):206-207.
- doi: 10.4167/jbv.2014.44.2.206
Cyclic guanosine monophosphate adenosine monophosphate (cGAMP) synthase (cGAS) detects human immunodeficiency virus (HIV) and produces cGAMP to induce cytokines. Reverse transcribed DNA of HIV is critical for triggering innate immune... -
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- A Case of Hyperinsulinism/hyperammonemia Syndrome
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Sung JY, Hong SY, Shin CH, Yang SW
- KMID: 1838802
- J Korean Soc Pediatr Endocrinol.
- 2005 Dec;10(2):236-240.
The hyperinsulinism/hyperammonemia (HI/HA) syndrome is a form of congenital hyperinsulinism. The children with HI/HA syndrome present recurrent symptomatic hypoglycemia and asymptomatic, persistent hyperammonemia, caused by mutations of the GLUD1 encoding... -
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- Evaluation for the Effects of Intrathecal Sildenafil on the Formalin- and Thermal-induced Nociception of Rats
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Yoon MH, Bae HB, Shin DJ, Kim CM, Jeong ST, Kim SJ, Choi JI
- KMID: 2278011
- Korean J Pain.
- 2006 Jun;19(1):17-21.
- doi: 10.3344/kjp.2006.19.1.17
BACKGROUND: Cyclic guanosine monophosphate (cGMP) plays an important role in the modulation of nociception. Although local sildenafil produces antinociception, by increasing cGMP through the inhibition of phosphodiesterase 5, the effect... -
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- Penile Erection Induced by Scoparone from Artemisia capillaris through the Nitric Oxide-Cyclic Guanosine Monophosphate Signaling Pathway
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Choi BR, Kim HK, Park JK
- KMID: 2398569
- World J Mens Health.
- 2017 Dec;35(3):196-204.
- doi: 10.5534/wjmh.17023
PURPOSE: The objective of this study was to evaluate the relaxant effect of scoparone from Artemisia capillaris on rabbit penile corpus cavernosum smooth muscle (PCCSM) and to elucidate the mechanism... -
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- Anti-tumor Effect of the Complex of Acriflavine and Guanosine (AG60)
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Hong EK, Kim HM, Lee KY, Chung YS, Yoo BI, Kim SG, Ahn ET, Han YB
- KMID: 1531906
- J Korean Cancer Assoc.
- 1997 Feb;29(1):29-37.
PURPOSE: The anti-tumor effect of the complex of acriflavine and guanosine (AG60) was investigated. MATERIALS AND METHODS: In vitro cytotoxicity of AG60 was measured using SRB assay, and in vivo... -
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- Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis
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Zhang X, Kim KM
- KMID: 2367617
- Biomol Ther.
- 2017 Jan;25(1):26-43.
- doi: 10.4062/biomolther.2016.186
Endocytosis is a process by which cells absorb extracellular materials via the inward budding of vesicles formed from the plasma membrane. Receptor-mediated endocytosis is a highly selective process where receptors... -
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- Nucleoside Diphosphate Kinase from Microorganisms
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Choi CH
- KMID: 2168678
- J Bacteriol Virol.
- 2013 Jun;43(2):92-98.
- doi: 10.4167/jbv.2013.43.2.92
Nucleoside diphosphate kinase (Ndk) is ubiquitous and highly conserved multifunctional key enzyme in nucleotide metabolism. It generates nucleoside triphosphates (NTPs) by transfer of gamma-phosphates from nucleoside triphosphates such as ATP... -
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- Medical Care Quality Improvement on the Groundwork of National Healthcare Insurance Financial Stability
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Chi HS
- KMID: 2185920
- J Korean Med Assoc.
- 2008 Aug;51(8):682-683.
- doi: 10.5124/jkma.2008.51.8.682
According to 2005 OECD health data, the total Korean expenditure on health in percentage of GDP is 6%, while other OECD countries spend an average 10% of their GDP. Accordingly,... -
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- Mycophenolic Acid Induced Apoptotic Signal Transduction in Molt-4 T-cells
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Choi SJ, Chung SY, Kim SK
- KMID: 2004711
- J Korean Surg Soc.
- 2002 Jan;62(1):8-17.
PURPOSE: Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase (IMPDH), is the active metabolite of the immunosuppressive drug, mycophenolate mofetil (MMF). MMF is used to prevent an immune-... -
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- Alteration of Nitric Oxide Synthase and Guanylyl Cyclase Activity in Rats with Ischemia/Reperfusion Renal Injury
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Bae EH, Kim SW
- KMID: 1587475
- Korean J Physiol Pharmacol.
- 2006 Dec;10(6):337-341.
The present study was designed to investigate the protein expression of nitric oxide synthase (NOS) and guanylyl cyclase (GC) activity in ischemia/perfusion (I/R) renal injury in rats. Renal I/R injury... -
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- Isolation of GTP binding from bovine brain
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Kim JH
- KMID: 2320404
- Yeungnam Univ J Med.
- 1993 Dec;10(2):360-368.
GTP binding protein (G-protein) associated with membrane and involved in signal transduction was isolated from bovine brain, and molecular weight of G protein was observed. As the results, cell membranes were... -
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- Prostaglandin E1 (Alprostadil) Intracavernosal Self-Injection Therapy in Erectile Dysfunction
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Seong BM, Kim JJ
- KMID: 1960313
- J Korean Androl Soc.
- 1997 Jun;15(1):65-69.
BACKGROUND: Intracavernosal self-injection is widely used as the first line therapy of erectile dysfunction. The principal drugs used are papaverine, phentolamine, and prostaglandin E1 (PGE1): other agents are phenoxybenxamine, thymoxamine,... -
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- Effect of Zaprinast, a Phosphodiesterse Inhibitor, on Formalin-induced Nociception and Hemodynamics in the Rat Spinal Cord
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Park SK, Kim CM, Jeong ST, Kim SJ, Shin DJ, Bae HB, Choi JI, Jeong SW, Chung SS, Yoo KY, Jeong CY, Yoon MH
- KMID: 2238924
- Korean J Anesthesiol.
- 2005 Jun;48(6):651-655.
- doi: 10.4097/kjae.2005.48.6.651
BACKGROUND: Cyclic guanosine monophosphate (cGMP) is involved in antinociception and vascular relaxation. The effects of zaprinast, which increases the level of cGMP by inhibiting phosphodiesterase, in the spinal cord... -
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- Guanosine 5′-monophosphate-chelated calcium and iron feed additives maintains egg production and prevents Salmonella Gallinarum in experimentally infected layers
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Noh HJ, Kim H, Heo SJ, Cho HH, Koh HB
- KMID: 2412446
- J Vet Sci.
- 2017 Sep;18(3):291-97.
- doi: 10.4142/jvs.2017.18.3.291
We evaluated the effects of guanosine 5′-monophosphate (GMP)-chelated calcium and iron (CaFe-GMP) on health and egg quality in layers experimentally infected with Salmonella Gallinarum. In this study, a CaFe-GMP feed... -
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- Effects of cGMP on Smooth Muscle alpha-Actin Expression in Cultured Human Corporal Smooth Muscle Cells
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Kim SW, Seo SI, Paick JS
- KMID: 1960294
- J Korean Androl Soc.
- 1997 Dec;15(2):91-96.
PURPOSE: Knowledge of the mechanisms controlling intracellular signal propagation in smooth muscle is of major importance in understanding erectile function and dysfunction. We examined the effects of cGMP on alpha-actin... -
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