- R1467H Variants of Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) are Associated with Type 2 Diabetes Mellitus in Koreans
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Jin QS, Kim SH, Piao SJ, Lim HA, Lee SY, Hong SB, Kim YS, Lee HJ, Nam M
- KMID: 2222364
- Korean Diabetes J.
- 2010 Dec;34(6):368-373.
- doi: 10.4093/kdj.2010.34.6.368
BACKGROUND: The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) functions as an activator of Rho GTPases and is thought to influence insulin signaling. The R1467H variant of ARHGEF11 has... -
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- Conserved Roles of MonA in Fungal Growth and Development in Aspergillus Species
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Son YE, Park HS
- KMID: 2470178
- Mycobiology.
- 2019 Dec;47(4):457-465.
- doi: 10.1080/12298093.2019.1677380
MonA is a subunit of a guanine nucleotide exchange factor that is important for vacuole passing and autophagy processes in eukaryotes. In this study, we characterized the function of MonA,... -
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- Mon1 Is Essential for Fungal Virulence and Stress Survival in Cryptococcus neoformans
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Son YE, Jung WH, Oh SH, Kwak JH, Cardenas M, Park HS
- KMID: 2428809
- Mycobiology.
- 2018 Jun;46(2):114-121.
- doi: 10.1080/12298093.2018.1468053
Mon1 is a guanine nucleotide exchange factor subunit that activates the Ypt7 Rab GTPase and is essential for vacuole trafficking and autophagy in eukaryotic organisms. Here, we identified and characterized... -
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- Activation of small Rho GTPases by blebbistatin in PC12 cells
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Kim EG, Shin EY
- KMID: 1498922
- J Biomed Res.
- 2013 Jun;14(2):60-64.
Neuronal differentiation is a complex biological process accompanying cytoskeletal reorganization, including neurite outgrowth and growth cone formation. Therefore, neuronal differentiation is critically regulated by actin-related signaling proteins, such as small... -
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- The role of the exocyst in renal ciliogenesis, cystogenesis, tubulogenesis, and development
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Lipschutz
- KMID: 2457718
- Kidney Res Clin Pract.
- 2019 Sep;38(3):260-266.
- doi: 10.23876/j.krcp.19.050
The exocyst is a highly conserved eight-subunit protein complex (EXOC1–8) involved in the targeting and docking of exocytic vesicles translocating from the trans-Golgi network to various sites in renal cells.... -
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- Mechanisms of Platelet Activation and Integrin alphaIIbeta3
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Joo SJ
- KMID: 2028756
- Korean Circ J.
- 2012 May;42(5):295-301.
- doi: 10.4070/kcj.2012.42.5.295
Platelet aggregation is not only an essential part of hemostasis, but also initiates acute coronary syndrome or ischemic stroke. The precise understanding of the activation mechanism of platelet aggregation is... -
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- Involvement of betaPIX in angiotensin II-induced migration of vascular smooth muscle cells
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Shin EY, Lee CS, Park MH, Kim DJ, Kwak SJ, Kim EG
- KMID: 756231
- Exp Mol Med.
- 2009 Jun;41(6):387-396.
- doi: 10.3858/emm.2009.41.6.044
Angiotensin II (Ang II) stimulates migration of vascular smooth muscle cell (VSMC) in addition to its contribution to contraction and hypertrophy. It is well established that Rho GTPases regulate cellular... -
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- Vav3, a GEF for RhoA, Plays a Critical Role under High Glucose Conditions
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Sha J, Na J, Lee JO, Kim N, Lee SK, Kim JH, Moon JW, Kim SJ, Lee HJ, Choi JI, Park SH, Kim HS
- KMID: 2169474
- Endocrinol Metab.
- 2014 Sep;29(3):363-370.
- doi: 10.3803/EnM.2014.29.3.363
BACKGROUND: The role of small GTPase molecules is poorly understood under high glucose conditions. METHODS: We analyzed the expression pattern of Vav3 in skeletal muscle C2C12 cells under high glucose culture... -
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- Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiation
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Ha YJ, Jeong JH, Park Y, Lee JR
- KMID: 1120132
- Exp Mol Med.
- 2012 Feb;44(2):138-148.
- doi: 10.3858/emm.2012.44.2.009
Previously, we demonstrated that the p190 Rho guanine nucleotide exchange factor (p190RhoGEF) was induced following CD40 stimulation of B cells. In this study, we examined whether p190RhoGEF and a downstream... -
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- beta PAK-interacting exchange factor may regulate actin cytoskeleton through interaction with actin
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Lee CS, Kim KY, Im JB, Choi JW, Kim HK, Park JS, Shin EY, Kim SR, Kim EG
- KMID: 1103327
- Exp Mol Med.
- 2004 Dec;36(6):582-587.
p21-activated kinase (PAK)-interacting exchange factor (PIX) is known to be involved in regulation of Cdc42/Rac GTPases and PAK activity. PIX binds to the proline-rich region of PAK, and regulates biological... -
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- Gene Expression Changes Associated with Sustained p16 Expression in Hepatocellular Carcinoma Cells
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Oh SJ, Im JY, Jung CH, Lee YB
- KMID: 1515491
- Immune Netw.
- 2004 Dec;4(4):237-243.
- doi: 10.4110/in.2004.4.4.237
BACKGROUND: The normal functions of the cell cycle inhibitor p16INK4a are frequently inactivated in many human cancers. Over 80% of hepatocellular carcinoma (HCC) cases lack a functional p16/Rb pathway. p16/Rb... -
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- Protective Effects of KH-204 in the Bladder of Androgen-Deprived Rats
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Bae WJ, Ha US, Choi JB, Kim KS, Kim SJ, Cho HJ, Hong SH, Lee JY, Wang Z, Hwang SY, Kim SW
- KMID: 2032826
- World J Mens Health.
- 2015 Aug;33(2):73-80.
- doi: 10.5534/wjmh.2015.33.2.73
PURPOSE: We investigated the protective effects of the herbal formulation KH-204 in the bladder of androgen-deprived rats. MATERIALS AND METHODS: Male rats aged eight weeks were randomly divided into four groups,... -
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- Synergistic induction of cancer cell migration regulated by Gbetagamma and phosphatidylinositol 3-kinase
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Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Woo DH, Lee HS, Ha HK, Bae SS
- KMID: 1387359
- Exp Mol Med.
- 2012 Aug;44(8):483-491.
Phosphatidylinositol 3-kinase (PI3K) is essential for both G protein-coupled receptor (GPCR)- and receptor tyrosine kinase (RTK)-mediated cancer cell migration. Here, we have shown that maximum migration is achieved by full... -
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