- Hereditary Spherocytosis Coexisting with UDP-Glucuronosyltransferase Deficiency Highly Suggestive of Crigler-Najjar Syndrome Type II
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Iijima S, Ohzeki T, Maruo Y
- KMID: 1779679
- Yonsei Med J.
- 2011 Mar;52(2):369-372.
- doi: 10.3349/ymj.2011.52.2.369
Patients with co-existing hereditary spherocytosis (HS) and UDP-glucuronosyltransferase 1A1 (UGT1A1) deficiency as Gilbert's syndrome (GS) have been reported, and previous studies have demonstrated an increased risk for developing gallstones in... -
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- A Case of Crigler-Najjar Syndrome Type 2 Diagnosed Using Genetic Mutation Analysis
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Kim SY, Lee SH, Koh H, Lee ST, Ki CS, Kim JW, Chung KS
- KMID: 2275358
- Korean J Pediatr Gastroenterol Nutr.
- 2008 Sep;11(2):219-222.
Crigler-Najjar syndrome is a rare inherited disease associated with unconjugated hyperbilirubinemia. It is inherited via an autosomal recessive pattern and is caused by mutation in one of the five exons... -
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- A Case of Congenital Hemolytic Anemia of Unknown Cause Combined with Gilbert's Syndrome
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Lim JW, Choi JH, Nam YH, Seo IS, Yoon SM, Koo MS
- KMID: 1485159
- Korean J Hematol.
- 2008 Mar;43(1):58-61.
- doi: 10.5045/kjh.2008.43.1.58
Congenital hemolytic anemia is mainly developed due to intrinsic defects of erythrocytes, but in some cases the cause of hemolytic anemia is unclear. Gilbert's syndrome shows mild, chronic unconjugated hyperbilirubinemia... -
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- A Case of Gilbert's Syndrome with Severe Neonatal Hyperbilirubinemia
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Hong YS, Jin JY, Lee WR
- KMID: 2321501
- J Korean Soc Neonatol.
- 2010 Nov;17(2):266-269.
Gilbert's syndrome is caused by a reduction in the activity of uridine diphosphate glucuronosyltransferase (UGT) and induces chronic, non-hemolytic unconjugated hyperbilirubinemia. It has been suggested that 3-10% of the population... -
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- UDP-glucuronosyltransferase 1A1 Gene Polymorphism in Severe Neonatal Hyperbilirubinemia
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Jeon JD, Jo HS, Lee SG, Byun SH, Yeo JS, Ahn YH, Chang SH, Kim SY, Choi JW
- KMID: 2144520
- J Korean Soc Neonatol.
- 2007 May;14(1):46-52.
PURPOSE: TATA box mutation/polymorphism in the promoter region of the bilirubin uridinediphosphoglucuronate glucuronosyltransferase 1A1 (UGT-1A1) gene is known to be an etiology of hyperbilirubinemia. This study examined if a TATA... -
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- A Study of Polymorphism in UDP-glucuronosyltransferase 1 (UGT-1A1) Promoter Gene in Korean Patients with Gilbert's Syndrome
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Kim YH, Yeon JE, Jung GM, Kim HJ, Kim JS, Byun KS, Bak YT, Lee CH
- KMID: 1123162
- Korean J Hepatol.
- 2002 Jun;8(2):132-138.
BACKGROUNDS/AIMS: Hepatic glucuronidating activity, essential for efficient biliary excretion of bilirubin, is reduced to about 30 percent of normal in patients with Gilbert's syndrome. Patients with Gilbert's syndrome have an... -
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- A Case of Hereditary Spherocytosis Coexisting with Gilbert's Syndrome
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Lee MJ, Chang YH, Kang SH, Mun SK, Kim H, Han CJ, Kim J, Kang HJ
- KMID: 1501640
- Korean J Gastroenterol.
- 2013 Mar;61(3):166-169.
- doi: 10.4166/kjg.2013.61.3.166
We recently encountered a case of hereditary spherocytosis coexisting with Gilbert's syndrome. Patient was initially diagnosed with Gilbert's syndrome and observed, but other findings suggestive of concurrent hemolysis, such as... -
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- The relationship between Gly71Arg and TATA box polymorphism of UGT1A1 gene and prolonged hyperbilirubinemia of breast milk feeding infant in Korean
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Lee JM, Han YJ, Kim JS, Kim ER
- KMID: 2280223
- Korean J Pediatr.
- 2008 Feb;51(2):150-155.
- doi: 10.3345/kjp.2008.51.2.150
PURPOSE: It has been known that breast milk cause prolonged unconjugated hyperbilirubinemia. UGT1A1 is a important gene of uridine diphosphate glucuronosyltransferase (UGT) which has a major role of bilirubin metabolism.... -
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- The Efficacy of UGT1A1 Polymorphism in Chemoradiation Therapy Using Irinotecan in Patients with Locally Advanced Rectal Cancer
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Oh SY, Kim YB, Chun MS, Suh KW
- KMID: 2334401
- J Korean Soc Coloproctol.
- 2007 Oct;23(5):344-349.
PURPOSE: Irinotecan (CPT-11) is hydrolyzed to an active SN-38, which is further detoxicated to SN-38G through conjugation by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) enzymes. There are many reports that UGT1A1... -
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- Correlation of UGT2B7 Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy
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Li H, Hu B, Guo Z, Jiang X, Su X, Zhang X
- KMID: 2428275
- Yonsei Med J.
- 2019 Jan;60(1):30-37.
- doi: 10.3349/ymj.2019.60.1.30
PURPOSE: The present study aimed to investigate correlations between uridine glucuronosyltransferase 2B7 (UGT2B7) -161 single nucleotide polymorphism C to T (C>T) and the occurrence of cardiotoxicity in Chinese breast cancer... -
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- Incidence of Atazanavir-associated Hyperbilirubinemia in Korean HIV Patients: 30 Months Follow-up Results in a Population with Low UDP-glucuronosyltransferase1A1*28 Allele Frequency
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Choe PG, Park WB, Song JS, Kim NH, Song KH, Park SW, Kim HB, Kim NJ, Oh MD
- KMID: 2157844
- J Korean Med Sci.
- 2010 Oct;25(10):1427-1430.
- doi: 10.3346/jkms.2010.25.10.1427
Hyperbilirubinemia is frequently observed in Caucasian HIV patients treated with atazanavir. UDP-glucuronosyltransferase 1A1 polymorphism, UGT1A1*28, which is associated with atazanavir-induced hyperbilirubinemia, is less common in Asians than in Caucasians. However,... -
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- Gene Expression in the Capsule Tissue of the Frozen Shoulder
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Kim JM, Kim YS, Ji JH, Lee JY, Yoo HH, Lee YK
- KMID: 2185596
- J Korean Orthop Assoc.
- 2010 Feb;45(1):65-72.
- doi: 10.4055/jkoa.2010.45.1.65
PURPOSE: To investigate the overall expression of extracellular matrix (ECM) and adhesion molecule genes using a gene array technique in the joint capsule of a frozen shoulder. MATERIALS AND METHODS: Tissues... -
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- Comprehensive Variant Screening of the UGT Gene Family
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Kim JY, Cheong HS, Park BL, Kim LH, Namgoong S, Kim JO, Kim HD, Kim YH, Chung MW, Han SY, Shin HD
- KMID: 1779911
- Yonsei Med J.
- 2014 Jan;55(1):232-239.
- doi: 10.3349/ymj.2014.55.1.232
PURPOSE: UGT1A1, UGT2B7, and UGT2B15 are well-known pharmacogenes that belong to the uridine diphosphate glucuronyltransferase gene family. For personalized drug treatment, it is important to study differences in the frequency... -
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- A case of concomitant Gilbert's syndrome and hereditary spherocytosis
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Lee HJ, Moon HS, Lee ES, Kim SH, Sung JK, Lee BS, Jeong HY, Lee HY, Eu YJ
- KMID: 1717328
- Korean J Hepatol.
- 2010 Sep;16(3):321-324.
- doi: 10.3350/kjhep.2010.16.3.321
We describe moderate hyperbilirubinemia in a 28-year-old man who suffered from gallstones and splenomegaly, with combined disorders of hereditary spherocytosis (HS) and Gilbert's syndrome (GS). Since it is difficult to... -
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- Enhancement of O-dealkylation in Mouse Liver by Dietary Administrations of BHA and BHT: Studies with Isolated Perfused Livers and Hepatic Microsomes
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Ji SC, Conway JG, Thurman RG, Cha YN
- KMID: 693021
- Yonsei Med J.
- 1986 Jun;27(2):106-113.
- doi: 10.3349/ymj.1986.27.2.106
Effects of feeding 2(3)-tert-butyl 4-hydroxyanisole (BHA) and 3, 5-di-tert-butyl 4-hydroxytoluene (BHT) on the rates of mixed function oxidation and conjugation enzyme reactions have been determined using isolated hepatic microsomal fractions... -
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- Transcriptional Regulation of Proteoglycans and Glycosaminoglycan Chain-synthesizing Glycosyltransferases by UV Irradiation in Cultured Human Dermal Fibroblasts
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Shin JE, Oh JH, Kim YK, Jung JY, Chung JH
- KMID: 2157881
- J Korean Med Sci.
- 2011 Mar;26(3):417-424.
- doi: 10.3346/jkms.2011.26.3.417
Various kinds of glycosaminoglycans (GAGs) and proteoglycans (PGs) have been known to be involved in structural and space-filling functions, as well as many physiological regulations in skin. To investigate ultraviolet... -
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