- Pancreatic glucokinase activity changes by plasma glucose levels in diabetic KK-mice
-
Choi JH, Han SH, Kim H
- KMID: 1700081
- J Korean Diabetes Assoc.
- 1993 Dec;17(4):367-375.
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Identification of Maturity-Onset Diabetes of the Young Caused by Glucokinase Mutations Detected Using Whole-Exome Sequencing
-
Cho EH, Min JW, Choi SS, Choi HS, Kim SW
- KMID: 2384090
- Endocrinol Metab.
- 2017 Jun;32(2):296-301.
- doi: 10.3803/EnM.2017.32.2.296
Glucokinase maturity-onset diabetes of the young (GCK-MODY) represents a distinct subgroup of MODY that does not require hyperglycemia-lowering treatment and has very few diabetes-related complications. Three patients from two families... -
- CITED
-
- Close
- SHARE
-
- Close
- MODY Syndrome
-
Hwang JS
- KMID: 2192880
- J Korean Soc Pediatr Endocrinol.
- 2010 Apr;15(1):1-6.
Maturity-onset diabetes of the young (MODY) is a heterogenous form of diabetes characterized by the early onset of diabetes, autosomal dominant inheritance, and impaired insulin secretion. MODY is mostly caused... -
- CITED
-
- Close
- SHARE
-
- Close
- The variation of pancreatic beta-cell specific glucokinase gene promoter at the position of -30 bp in Koreans with gestational diabetes mellitus
-
Kim JW, Yang IM, Kim SW, Kim YS, Choi YK, Woo JT, Kim SY, Oh SJ, Paeng JR, Chang HC
- KMID: 2143094
- Korean J Med.
- 1999 Nov;57(5):916-924.
Glucokinase is expressed only in both liver and pancreatic beta cells and has a key role in the regulation of glucose metabolism in these tissues. A number of gene defects associated... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of medicinal herb water extracts on expression of hepatic glucokinase, pyruvate dehydrogenase and acetyl-CoA carboxylase mRNA
-
Kim HS, Kim TW, Kim DJ, Lee JS, Choe M
- KMID: 2269389
- Korean J Nutr.
- 2013 Apr;46(2):119-125.
- doi: 10.4163/kjn.2013.46.2.119
We studied the anti-diabetic effects of medicinal herb water extracts on expression of hepatic glucokinase (GCK), pyruvate dehydrogenase (PDH), and acetyl-CoA carboxylase (ACC) mRNA. The medicinal herbs used for experiments... -
- CITED
-
- Close
- SHARE
-
- Close
- Study of the mechanisms underlying increased glucose absorption in Smilax china L. leaf extract-treated HepG2 cells
-
Kang YH, Kim DJ, Kim KK, Lee SM, Choe M
- KMID: 2327149
- J Nutr Health.
- 2014 Jun;47(3):167-175.
PURPOSE: Previous studies have shown that treatment with Smilax china L. leaf extract (SCLE) produces antidiabetic effects due to alpha-glucosidase inhibition. In this study, we examined the mechanism underlying these... -
- CITED
-
- Close
- SHARE
-
- Close
- HNF1 and/or HNF3 may contribute to the tissue specific expression of glucokinase gene
-
Cha JY, Kim HI, Im SS, Li TZ, Ahn YH
- KMID: 1085740
- Exp Mol Med.
- 2001 Jun;33(2):59-63.
A possible role of hepatocyte nuclear factor 1 (HNF1) or HNF3, a predominant trans-acting factors of hepatic or pancreatic beta-cells, was examined on the tissue specific interdependent expression of glucokinase... -
- CITED
-
- Close
- SHARE
-
- Close
- A Case of Persistent Hyperinsulinemic Hypoglycemia Treated with Diazoxide
-
Kim MS, Park EH, Kim SY, Lee DY
- KMID: 1520749
- J Korean Soc Pediatr Endocrinol.
- 2007 Dec;12(2):164-167.
Congenital hyperinsulinism (CHI), the most important cause of hyperglycemia in early infancy, is a heterogenous disease characterized by dysregulation of insulin secretion. Mutations in five proteins have been associated with... -
- CITED
-
- Close
- SHARE
-
- Close
- Glucose Regulated Production of Human Insulin in Genetically Modified Myoblast Cell Line (C2C12)
-
Oh S, Woo JT, Kim SW, Kim JW, Kim YS
- KMID: 2391907
- J Korean Endocr Soc.
- 2006 Dec;21(6):526-535.
BACKGROUND: To develop somatic gene therapy model for diabetes mellitus, it is the most important to control it by glucose concentration. In order to develop the myoblasts that produce insulin... -
- CITED
-
- Close
- SHARE
-
- Close
- A Journey to Understand Glucose Homeostasis: Starting from Rat Glucose Transporter Type 2 Promoter Cloning to Hyperglycemia
-
Ahn YH
- KMID: 2449622
- Diabetes Metab J.
- 2018 Dec;42(6):465-471.
- doi: 10.4093/dmj.2018.0116
My professional journey to understand the glucose homeostasis began in the 1990s, starting from cloning of the promoter region of glucose transporter type 2 (GLUT2) gene that led us to... -
- CITED
-
- Close
- SHARE
-
- Close
- Glucokinase gene mutation in non-insulin-dependent diabetes mellitus (NIDDM), and secondary diabetes in Koreans
-
Nam JH, Lee HC, Kim YE, Kwon SH, Yoon YS, Park SW, Cha BS, Won YJ, Song YD, Lee EJ, Lim SK, Kim KR, Huh KB
- KMID: 2306363
- Korean J Med.
- 1998 Jun;54(6):755-764.
OBJECTIVES: Mutations in the glucokinase (GCK) gene are considered a possible cause of maturity-onset diabetes of the young. The purpose of this study was to evaluate the contribution of this... -
- CITED
-
- Close
- SHARE
-
- Close
- New Perspectives in Pediatric Nonalcoholic Fatty Liver Disease: Epidemiology, Genetics, Diagnosis, and Natural History
-
Ko JS
- KMID: 2462089
- Pediatr Gastroenterol Hepatol Nutr.
- 2019 Nov;22(6):501-510.
- doi: 10.5223/pghn.2019.22.6.501
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. The global prevalence of pediatric NAFLD from general populations is 7.6%. In obese children,... -
- CITED
-
- Close
- SHARE
-
- Close
- Sargassum coreanum extract alleviates hyperglycemia and improves insulin resistance in db/db diabetic mice
-
Park MH, Nam YH, Han JS
- KMID: 2313867
- Nutr Res Pract.
- 2015 Oct;9(5):472-479.
- doi: 10.4162/nrp.2015.9.5.472
BACKGROUND/OBJECTIVES: The goal of this study was to examine the effect of Sargassum coreanum extract (SCE) on blood glucose concentration and insulin resistance in C57BL-KsJ-db/db mice. MATERIALS/METHODS: For 6 weeks, male... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of Fermented Yacon (Smallanthus Sonchifolius) Leaves Tea on Blood Glucose Levels and Glucose Metabolism in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Mice
-
Kim IS, Lee J, Lee JS, Shin DY, Kim MJ, Lee MK
- KMID: 2268021
- Korean J Nutr.
- 2010 Aug;43(4):333-341.
- doi: 10.4163/kjn.2010.43.4.333
The aim of this study was to investigate the hypolgycemic activity of water extract of fermented yacon (Smallanthus sonchifolius) leaves tea (Yacon LWE) in high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic mice.... -
- CITED
-
- Close
- SHARE
-
- Close
- Hyperglycemia in pediatric age: could it be maturity onset diabetes of the young? Case reports and review of the literature
-
Cascais M, Pereira E, Vieira A, Venâncio , Ramos L, Moleiro P
- KMID: 2468730
- Ann Pediatr Endocrinol Metab.
- 2019 Dec;24(4):262-266.
- doi: 10.6065/apem.2019.24.4.262
Maturity Onset Diabetes of the Young (MODY) includes a clinically and genetically heterogeneous group of diabetes subtypes with MODY-2 being the second most prevalent form. We report 2 cases of... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Phytoestrogens on Glucose Metabolism in C57BL/KsOlaHsd-db/db Mice
-
Seo BH, Kim KO, Lee JH, Lee HS
- KMID: 2268543
- Korean J Nutr.
- 2011 Aug;44(4):275-283.
- doi: 10.4163/kjn.2011.44.4.275
This study was conducted to evaluate the antihyperglycemic effects of three phytoestrogens, genistein, coumestrol, and enterolactone, in type 2 diabetic animals. Forty male C57BL/KsOlaHsd-db/db mice were used as a diabetic... -
- CITED
-
- Close
- SHARE
-
- Close
- Hypoglycemic effect of Rehmannie Radix Preparata (Sookjihwang) extract in streptozotocin-induced diabetic rats
-
Kang SJ, Bao CL, Park S, Kim AJ
- KMID: 2313478
- Nutr Res Pract.
- 2010 Oct;4(5):438-442.
Rhemannie Radix Preparata (RRP) has been previously employed in traditional oriental medicine as a treatment for diabetic thirst and improving blood flow. The aim of this study was to evaluate... -
- CITED
-
- Close
- SHARE
-
- Close
- Transdifferentiation of Enteroendocrine K-cells into Insulin-expressing Cells
-
Lee E, Yu JM, Lee MK, Ryu GR, Ko SH, Ahn YB, Moon SD, Song KH
- KMID: 2298053
- Korean Diabetes J.
- 2009 Dec;33(6):475-484.
- doi: 10.4093/kdj.2009.33.6.475
BACKGROUND: Despite a recent breakthough in human islet transplantation for treating type 1 diabetes mellitus, the limited availability of donor pancreases remains a major obstacle. Endocrine cells within the gut... -
- CITED
-
- Close
- SHARE
-
- Close
- Increased glucose metabolism and alpha-glucosidase inhibition in Cordyceps militaris water extract-treated HepG2 cells
-
Kim DJ, Kang YH, Kim KK, Kim TW, Park JB, Choe M
- KMID: 2407765
- Nutr Res Pract.
- 2017 Jun;11(3):180-189.
- doi: 10.4162/nrp.2017.11.3.180
BACKGROUND/OBJECTIVES: Recent living condition improvements, changes in dietary habits, and reductions in physical activity are contributing to an increase in metabolic syndrome symptoms including diabetes and obesity. Through such societal... -
- CITED
-
- Close
- SHARE
-
- Close
- Mitochondrial DNA point mutations in Korean NIDDM patients
-
Kim SK, Park KS, Shin CS, Kim SY, Cho BY, Lee HK, Koh CS
- KMID: 2008300
- J Korean Diabetes Assoc.
- 1997 Jun;21(2):147-155.
BACKGROUND: There are a few genes with proven potential for causing some form of NIDDM, These include the insulin gene, the insulin receptor gene, a gene linked to the adenosine... -
- CITED
-
- Close
- SHARE
-
- Close
