- Immunohistochemical Classification of Primary and Secondary Glioblastomas
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Lee KS, Choe G, Nam KH, Seo AN, Yun S, Kim KJ, Cho HJ, Park SH
- KMID: 2012155
- Korean J Pathol.
- 2013 Dec;47(6):541-548.
BACKGROUND: Glioblastomas may develop de novo (primary glioblastomas, P-GBLs) or through progression from lower-grade astrocytomas (secondary glioblastomas, S-GBLs). The aim of this study was to compare the immunohistochemical classification of... -
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- Role of Epidermal Growth Factor Receptor and the HER-2 Gene in Hormone Refractory Prostate Cancer
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Cho KS, Kim DJ, Lee JS, Cho NH, Park K, Ham WS, Choi YD
- KMID: 2312032
- Korean J Urol.
- 2008 Jan;49(1):24-30.
PURPOSE: Amplification and mutation of the epidermal growth factor receptor(EGFR) and HER-2 genes were analyzed in the tissues of hormone refractory prostate cancer(HRPC) patients. MATERIALS AND METHODS: Gene amplifications of the... -
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- Neuroepithelial Tumor Relevant Genes
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Lee HC, Kim DW, Choi IJ, Lee JC, Son EI, Yim MB, Kim IH
- KMID: 1673073
- J Korean Neurosurg Soc.
- 1994 Aug;23(8):924-931.
Cancer may be a disease of genes, arising from genetic damage of diverse sorts-recessive and dominant mutations, large rearrangement of DNA and gene translocation on chromosomes, all leading to distorisions... -
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- Gefitinib Treatment for Pulmonary Sarcomatoid Carcinoma Driven by an EGFR Mutation: Two Cases
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Kim JY, Lim Y, Lee E, Kim MS, Lee DW, Kim TM, Lee SH
- KMID: 1833860
- Korean J Med.
- 2013 Mar;84(3):446-451.
- doi: 10.3904/kjm.2013.84.3.446
Sarcomatoid carcinoma of the lung is defined as a group of poorly differentiated non-small cell carcinomas that contain a component of sarcoma or a sarcoma-like element. Most sarcomatoid carcinomas are... -
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- Peptide Nucleic Acid Clamping Versus Direct Sequencing for the Detection of EGFR Gene Mutation in Patients with Non-small Cell Lung Cancer
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Yoon SH, Choi YD, Oh IJ, Kim KS, Choi H, Chang J, Shin HJ, Park CK, Kim YC
- KMID: 2403384
- Cancer Res Treat.
- 2015 Oct;47(4):661-669.
- doi: 10.4143/crt.2014.282
PURPOSE: Direct sequencing (DS) is the standard method for detection of epidermal growth factor receptor (EGFR) gene mutation in non-small cell lung cancer (NSCLC); however, low detection sensitivity is a... -
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- Mutational Analysis of the Epidermal Growth Factor Receptor Gene in Gastrointestinal Stromal Tumors
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Yoo NJ, Lee JW, Soung YH, Jeon HM, Nam SW, Kim SY, Park WS, Lee JY, Lee SH
- KMID: 2372342
- J Korean Gastric Cancer Assoc.
- 2004 Dec;4(4):268-271.
PUPOSE: Most gastrointestinal stromal tumors (GISTs) have gain-of-function mutations of the KIT or the platelet-derived growth factor receptor alpha (PDGFRA) genes, but approximately 10% of the GISTs are wild types... -
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- Molecular Diagnosis in Lung Cancer
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Lee KY
- KMID: 2200022
- J Lung Cancer.
- 2010 Jun;9(1):9-14.
- doi: 10.6058/jlc.2010.9.1.9
The advent of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib and erlotinib has opened a new horizon for the therapeutic options for patients with advanced lung cancer.... -
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- Cyto - molecular Biologic Characterization of c - myc , erb B and EGF - Receptor in Squamous Cell Carcinoma
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Lee KS, Choi YY, Song JY, Choi IJ, Jang SI, Baek WK, Suh MH
- KMID: 2230813
- Korean J Dermatol.
- 1994 Apr;32(2):223-233.
BACKGROUND: Oncogenes and EGF-Receptor(EGFR) may be involved n different stages of the multistep carcinogenesis process. A specific pattern of karyotypic abnormalities in solid tumors can be detected by cytogenetic methods. OBJECTIVE:... -
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- Increased expression of the epidermal growth factor receptor gene in psoriasis
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Choi YY, Lee KS, Lee SS, Chang ES, Song JY
- KMID: 2303592
- Korean J Dermatol.
- 1992 Aug;30(4):431-438.
Psoriasis is characterized by disregulation of keratinocyte growth with profound epidermal hyperplasia. Keratinocyte hyperplasia in psoriasis may be expained in part by overproduction of growth factor, and by altered metabolism... -
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- Screening of Epidermal Growth Factor Receptor Gene Mutation in Non-Small Cell Lung Cancer Using a PCR-Based Enzymatic Digestion Method
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Jung YJ, Park SJ, Lee SB, Kim YT, Park JY, Park IK, Kang CH, Kim JH
- KMID: 2199833
- J Lung Cancer.
- 2012 Dec;11(2):77-83.
- doi: 10.6058/jlc.2012.11.2.77
PURPOSE: We applied a simplified method using polymerase chain reaction (PCR)-based enzymatic digestion for the detection of epidermal growth factor receptor (EGFR) mutation. MATERIALS AND METHODS: We selected 74 samples of... -
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- Clinicopathologic Analysis of Epidermal Growth Factor Receptor Status in Non-small Cell Lung Cancer: Protein Expression, Gene Amplification and Survival Analysis
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Lee S, Choi J, Jang SJ
- KMID: 1521612
- Korean J Pathol.
- 2007 Dec;41(6):387-392.
BACKGROUND: Abnormal over-expression or gene amplification of epidermal growth factor receptor (EGFR) is important in the prognosis of non-small cell lung cancer (NSCLC). We investigated the frequency of EGFR protein... -
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- The EGFR Protein Expression and the Gene Copy Number Changes in Renal Cell Carcinomas
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Lee S, An J, Kim A, Kim YS, Kim I, Genitourinary Pathology Study Group
- KMID: 1472619
- Korean J Pathol.
- 2009 Oct;43(5):413-419.
- doi: 10.4132/KoreanJPathol.2009.43.5.413
BACKGROUND: The epidermal growth factor receptor (EGFR) is known to be involved in many tumor promoting activities. EGFR inhibition has been tried as a therapeutic modality in many human malignancies. METHODS:... -
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- EGFR Gene Amplification and Protein Expression in Invasive Ductal Carcinoma of the Breast
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Hwangbo W, Lee JH, Ahn S, Kim S, Park KH, Kim CH, Kim I
- KMID: 2277454
- Korean J Pathol.
- 2013 Apr;47(2):107-115.
BACKGROUND: The epidermal growth factor receptor (EGFR) is a surrogate marker for basal-like breast cancer. A recent study suggested that EGFR may be used as a target for breast cancer... -
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- Intron 1 Polymorphism, Mutation and the Protein Expression of Epidermal Growth Factor Receptor in Relation to the Gefitinib Sensitivity of Korean Lung Cancer Patients
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Kim MJ, Shin KC, Lee KH
- KMID: 1472635
- Korean J Pathol.
- 2009 Dec;43(6):509-516.
- doi: 10.4132/KoreanJPathol.2009.43.6.509
BACKGROUND: Epidermal growth factor receptor (EGFR) intron 1 polymorphism in non-small cell lung cancer (NSCLC) has been found to have therapeutic implications for the patients treated with EGFR tyrosine kinase... -
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- Mutations of the Epidermal Growth Factor Receptor Gene in Triple-Negative Breast Cancer
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Kim A, Jang MH, Lee SJ, Bae YK
- KMID: 2389752
- J Breast Cancer.
- 2017 Jun;20(2):150-159.
- doi: 10.4048/jbc.2017.20.2.150
PURPOSE: Epidermal growth factor receptor (EGFR) is considered a potential therapeutic target for anti-EGFR therapy in triple-negative breast cancer (TNBC). However, the frequency of EGFR gene mutation in TNBC is... -
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- Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosine Kinase Inhibitor Treatment
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Lee HJ, Xu X, Kim H, Jin Y, Sun P, Kim JE, Chung JH
- KMID: 1837571
- Korean J Pathol.
- 2013 Feb;47(1):52-60.
BACKGROUND: The aims of this study were to evaluate the abilities of direct sequencing (DS), peptide nucleic acid (PNA) clamping, and pyrosequencing methods to detect epidermal growth factor receptor (EGFR)... -
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- In Situ Hybridization of EGFR mRNA in Normal, Dysplasic, Carcinoma In Situ and Malignant Cervical Tissues
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Kim TE, Kim HK, Park JS, Kim JW, Kang JH, Lee AH, Kim JH, Namkoong S
- KMID: 1675665
- Korean J Gynecol Oncol Colposc.
- 1995 Dec;6(4):235-243.
The specific receptor for epidermal growth factor(EGFR) was first purified from the A431 cell line which was derived from an epiderrnal carcinoma of the vulva. It is a 170,000 dalton... -
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- Factors that Predict Clinical Benefit of EGFR TKI Therapy in Patients with EGFR Wild-Type Lung Adenocarcinoma
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Kim SY, Myung JK, Kim HR, Na II, Koh JS, Baek HJ, Kim CH
- KMID: 2441731
- Tuberc Respir Dis.
- 2019 Jan;82(1):62-70.
- doi: 10.4046/trd.2018.0004
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancers have emerged as key predictive biomarkers in EGFR tyrosine kinase inhibitor (TKI) treatment. However, a few patients with... -
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- Comparative Analysis of Peptide Nucleic Acid (PNA)-Mediated Real-Time PCR Clamping and DNA Direct Sequencing for EGFR Mutation Detection
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Kim HJ, Kim WS, Shin KC, Lee GH, Kim MJ, Lee JE, Song KS, Kim SY, Lee KY
- KMID: 2319463
- Tuberc Respir Dis.
- 2011 Jan;70(1):21-27.
BACKGROUND: Although the gold standard method for research trials on epidermal growth factor receptor (EGFR) mutations has been direct sequencing, this approach has the limitations of low sensitivity and of... -
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- Predicting the Treatment Response Using a Direct Sequencing Method for EGFR in Non-Squamous, Non-Small Cell Lung Cancer
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Park JY, Jang SH, Kim HJ, Park YB, Kwon JH, Song HH, Lee KW, Kim JH, Kim JH, Park SH, Hwang YI, Kim DG, Jung KS
- KMID: 2264117
- Korean J Med.
- 2011 Nov;81(5):611-622.
BACKGROUND/AIMS: Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancers (NSCLCs) have emerged as a key predictive biomarker for EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment and should be... -
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