- Gene Therapy and Cell Transplantation for Alzheimer's Disease and Spinal Cord Injury
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Blesch A, Tuszynski
- KMID: 1726142
- Yonsei Med J.
- 2004 Jun;45(Suppl):S28-S31.
- doi: 10.3349/ymj.2004.45.Suppl.28
The targeted delivery of genes and the transplantation of suitable cell types into the adult nervous system have received considerable interest over the last years. The development of improved vector... -
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- Gene therapy of scarring: a lesson learned from fetal scarless wound healing
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Liu W, Cao Y, Longaker M
- KMID: 720678
- Yonsei Med J.
- 2001 Dec;42(6):634-645.
- doi: 10.3349/ymj.2001.42.6.634
Cutaneous wounding in adult humans and higher vertebrate animals results in scar formation. In contrast, both human and animal fetuses, at early gestational ages, exhibit skin wound healing without scarring.... -
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- The effects of transferring tumor suppressor gene p16INK4A to p16INK4A-deleted cancer cells
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Lee KY, Yoo CG, Han SK, Shim YS, Kim YW
- KMID: 759084
- Korean J Intern Med.
- 1999 Jan;14(1):53-58.
OBJECTIVES: p16 is known to be an important tumor suppressor gene and is also called MTS1 (multiple tumor suppressive gene 1). Especially in the case of non-small cell... -
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- RNA Interference in Functional Genomics and Medicine
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Kim VN
- KMID: 2157643
- J Korean Med Sci.
- 2003 Jun;18(3):309-318.
- doi: 10.3346/jkms.2003.18.3.309
RNA interference (RNAi) is the sequence-specific gene silencing induced by double-stranded RNA (dsRNA). Being a highly specific and efficient knockdown technique, RNAi not only provides a powerful tool for functional... -
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- Combination treatment for osteosarcoma with baculoviral vector mediated gene therapy (p53) and chemotherapy (adriamycin)
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Song SU, Boyce FM
- KMID: 755117
- Exp Mol Med.
- 2001 Mar;33(1):46-53.
The insect baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) has been evaluated as a vector for gene delivery to human tumor cells. A human osteogenic sarcoma cell line, Saos-2,... -
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- Targeted Molecular Imaging
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Kim EE
- KMID: 1111248
- Korean J Radiol.
- 2003 Dec;4(4):201-210.
- doi: 10.3348/kjr.2003.4.4.201
Molecular imaging aims to visualize the cellular and molecular processes occurring in living tissues, and for the imaging of specific molecules in vivo, the development of reporter probes and dedicated... -
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- Adenoviral mediated hepatocyte growth factor gene attenuates hyperglycemia and beta cell destruction in overt diabetic mice
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Park MK, Kim DK, Lee HJ
- KMID: 1119330
- Exp Mol Med.
- 2003 Dec;35(6):494-500.
Hepatocyte growth factor (HGF) is a potent mitogen and promoter of proliferation of insulin producing beta cells of pancreatic islets. To study the role of HGF, an adenoviral vector carrying... -
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- Gene and Cell Replacement via Neural Stem Cells
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Kim HT, Kim IS, Lim SE, Lee IS, Park KI
- KMID: 1726143
- Yonsei Med J.
- 2004 Jun;45(Suppl):S32-S40.
- doi: 10.3349/ymj.2004.45.Suppl.32
Neural stem cells (NSCs) are operationally defined by their ability to self-renew, to differentiate into cells of all glial and neuronal lineages throughout the neuraxis, and to populate developing or... -
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- Enhanced Expressions and Histological Characteristics of Intravenously Administered Plasmid DNA in Rat Lung
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Rha SJ, Wang YP
- KMID: 2157563
- J Korean Med Sci.
- 2001 Oct;16(5):567-572.
- doi: 10.3346/jkms.2001.16.5.567
Cationic liposome-mediated gene transfection is a promising method for gene therapy. In this study, the transfection efficiency and histological patterns were evaluated in rat lung after intravenous administration via femoral... -
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- In vitro and in vivo gene therapy with CMV vector-mediated presumed dog beta-nerve growth factor in pyridoxine-induced neuropathy dogs
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Chung JY, Choi JH, Shin IS, Choi EW, Hwang CY, Lee SK, Youn HY
- KMID: 1104911
- J Vet Sci.
- 2008 Dec;9(4):367-373.
- doi: 10.4142/jvs.2008.9.4.367
Due to the therapeutic potential of gene therapy for neuronal injury, many studies of neurotrophic factors, vectors, and animal models have been performed. The presumed dog beta-nerve growth factor (pdbeta-NGF)... -
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- Adenovirus-mediated p53 tumor suppressor gene therapy against subcutaneous HuH7 hepatoma cell line nodule of nude mice
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Choi JY, Park YM, Byun BH, Kim BS, Hong EG, Shin DY, Seong YR, Im DS
- KMID: 646305
- J Korean Med Sci.
- 1999 Jun;14(3):271-276.
- doi: 10.3346/jkms.1999.14.3.271
Mutations of the tumor-suppressor gene p53 have been found in 30-50% cases of hepatocellular carcinoma (HCC). In this study, E1-negative adenoviral vector encoding wild-type p53 under the control of the... -
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- Biologic Therapy for Brain Cancers - Based on Cellular and Immunobiology
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Okada H
- KMID: 1726149
- Yonsei Med J.
- 2004 Jun;45(Suppl):S68-S70.
- doi: 10.3349/ymj.2004.45.Suppl.68
The overall goal of our research projects is to develop effective immunotherapeutic regimens, particularly combining vaccine and gene therapy/ cell therapy strategies. For the development of clinically effective immunotherapy for... -
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- Increased Anti-tumor Effect by a Combination of HSV Thymidine Kinase Suicide Gene Therapy and Interferon-gamma/GM-CSF Cytokine Gene Therapy in CT26 Tumor Model
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Yang SH, Oh TK, Kim ST
- KMID: 2157739
- J Korean Med Sci.
- 2005 Dec;20(6):932-937.
- doi: 10.3346/jkms.2005.20.6.932
The potential therapeutic benefit of introducing IFN-gamma and GM-CSF genes in combination with the HSVtk suicide gene into subcutaneously implanted CT26 tumor cells was compared with that from each treatment... -
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- Low-dose radiation response of the p21(WAF1/CIP1) gene promoter transduced by adeno-associated virus vector
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Nenoi M, Daino K, Ichimura S, Takahash S, Akuta T
- KMID: 1098090
- Exp Mol Med.
- 2006 Oct;38(5):553-564.
In cancer gene therapy, restriction of antitumor transgene expression in a radiation field by use of ionizing radiation-inducible promoters is one of the promising approaches for tumor-specific gene delivery. Although... -
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- Transplantation of neural stem cells: cellular & gene therapy for hypoxic-ischemic brain injury
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Park KI
- KMID: 1114570
- Yonsei Med J.
- 2000 Dec;41(6):825-835.
- doi: 10.3349/ymj.2000.41.6.825
We have tracked the response of host and transplanted neural progenitors or stem cells to hypoxic-ischemic (HI) brain injury, and explored the therapeutic potential of neural stem cells (NSCs) injected... -
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- Development of ligand-dependent regulatory system and its application to gene therapy of insulin-dependent diabetes mellitus
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Kim JM, Kim SJ, Lee HC, Kim KS
- KMID: 1110122
- Exp Mol Med.
- 2006 Aug;38(4):385-392.
To develop an inducible expression system, the enhanced artificial nuclear receptors and target reporters were constructed. Artificial nuclear receptors were generated by fusing three domains, consisting of DNA-binding domain (DBD)... -
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- Protective Effect of Recombinant Adeno-Associated Virus 2/8-Mediated Gene Therapy from the Maternal Hyperphenylalaninemia in Offsprings of a Mouse Model of Phenylketonuria
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Jung SC, Park JW, Oh HJ, Choi JO, Seo KI, Park ES, Park HY
- KMID: 1783076
- J Korean Med Sci.
- 2008 Oct;23(5):877-883.
- doi: 10.3346/jkms.2008.23.5.877
Phenylketonuria (PKU) is an autosomal recessively inherited metabolic disorder caused by a deficiency of phenylalanine hydroxylase (PAH). The accumulation of phenylalanine leads to severe mental and psychomotor retardation, and the... -
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- Prolonged hypotensive effect of human tissue kallikrein gene delivery and recombinant enzyme administration in spontaneous hypertension rats
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Sun H, Zhang L, Wang A, Xue Z
- KMID: 755661
- Exp Mol Med.
- 2004 Feb;36(1):23-27.
To evaluate the feasibility of treating hypertension by human tissue kallikrein gene (KLK1) delivery and by enzyme (rK1) administration, two recombinant vectors expressing KLK1 cDNA were constructed for gene delivery... -
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- Potentials and limitations of adenovirus-p53 gene therapy for brain tumors
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Hong YK, Joe YA, Yang YJ, Lee KS, Son BC, Jeun SS, Chung DS, Cho KK, Park CK, Kim MC, Kim HK, Yung WK, Kang JK
- KMID: 1128631
- J Korean Med Sci.
- 2000 Jun;15(3):315-322.
- doi: 10.3346/jkms.2000.15.3.315
We investigated the antineoplastic potentials of recombinant adenovirus containing wild-type p53 cDNA (Ad5CMV-p53) for malignant gliomas. In four human glioma cell lines (U-251 and LG expressing endogenous mutant p53, and... -
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- Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria
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Park ES, Oh HJ, Kruger WD, Jung SC, Lee JS
- KMID: 1115943
- Exp Mol Med.
- 2006 Dec;38(6):652-661.
Homocystinuria is a metabolic disorder caused by a deficiency of cystathionine b-synthase (CBS). The major clinical symptoms of this disease are mental retardation, lens dislocation, vascular disease with life-threatening thromboembolisms,... -
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