- Targeting efficiency of a-1,3-galactosyl transferase gene in pig fetal fibroblast cells
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Jin DI, Lee SH, Choi JH, Lee JS, Lee JE, Park KW, Seo JS
- KMID: 1119341
- Exp Mol Med.
- 2003 Dec;35(6):572-577.
Animal cloning technology with somatic cells provides an alternative tool to conventional methods for producing transgenic animals. Gene targeting in animals is made feasible using somatic cells with homologous recombination... -
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- Development of a Mycobacterial Gene Knock-out System using Sequence-specific Recombinase FLP/FRT and its Application to the Construction of a Rhamnose Biosynthetic Gene rmlD Deletion Mutant
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Lee KC, Lee JS, Lee SJ, Lee KH, Lee TJ, Shin HJ, Choi JE, Park HS, Kim SK, Lee TY
- KMID: 1573280
- J Bacteriol Virol.
- 2002 Sep;32(3):221-230.
Development of a new and effecient tuberculosis vaccine is very important since the efficacy of the only available vaccine against tuberculosis, BCG, is variable among races and different ages. Attempts... -
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- Blood Pressure Regulation by Vasoactive Peptide Genes: Transgenic And Knockout Animal Models
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Ahn D
- KMID: 2134792
- Electrolyte Blood Press.
- 2005 Mar;3(1):14-23.
Hypertension is a polygenic and multifactorial disease and is intimately related to salt homeostasis. Four important vasoactive peptide systems participate in regulating blood pressure and salt homeostasis. Their interplay is... -
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- Isolation of Mouse Ig Heavy and Light Chain Genomic DNA Clones, and Construction of Gene Knockout Vector for the Generation of Humanized Xenomouse
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Lee HK, Cha SH
- KMID: 1974523
- Immune Netw.
- 2002 Dec;2(4):233-241.
- doi: 10.4110/in.2002.2.4.233
BACKGROUND: Monoclonal antibodies (mAb) of rodent origin are produced with ease by hybridoma fusion technique, and have been successfully used as therapeutic reagents for humans after humanization by genetic engineering.... -
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- Ovarian cancer related gene targeting with large circular antisense library
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Doh KO, Chun GS, Sim JC, Yang HS
- KMID: 2273741
- Korean J Obstet Gynecol.
- 2009 Jul;52(7):724-733.
OBJECTIVE: The aim of this study is to find out the genes which are related to ovarian cancer cell growth using large circular antisense library. METHODS: Clones for antisense library were... -
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- IL-12 p40-Expressing Immune Cells Revealed by Cytokine Reporter Mouse System
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Gi M, Kim J, Im W, Youn J, Hong S
- KMID: 2283675
- Korean J Phys Anthropol.
- 2009 Mar;22(1):95-105.
Interleukin-12 (IL-12), consisting of p35 and p40, plays important roles in linking innate and adaptive immunity. While p35 is constitutively expressed, IL-12 p40 gene expression is induced upon activation by... -
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- Molecular regulation of kidney development
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Chai OH, Song CH, Park SK, Kim W, Cho ES
- KMID: 2046754
- Anat Cell Biol.
- 2013 Mar;46(1):19-31.
- doi: 10.5115/acb.2013.46.1.19
Genetically engineered mice have provided much information about gene function in the field of developmental biology. Recently, conditional gene targeting using the Cre/loxP system has been developed to control the... -
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- Transcriptional targeting of gene expression in breast cancer by the promoters of protein regulator of cytokinesis 1 and ribonuclease reductase 2
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Yun HJ, Cho YH, Moon Y, Park YW, Yoon HK, Kim YJ, Cho SH, Lee YI, Kang BS, Kim WJ, Park K, Seo W
- KMID: 756337
- Exp Mol Med.
- 2008 Jun;40(3):345-353.
- doi: 10.3858/emm.2008.40.3.345
For cancer gene therapy, cancer-specific over-expression of a therapeutic gene is required to reduce side effects derived from expression of the gene in normal cells. To develop such an expression... -
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- Targeted RNA recombination of the membrane and nucleocapsid protein genes between mouse hepatitis virus and bovine coronavirus
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Koljesar G, Yoo D
- KMID: 1119210
- J Vet Sci.
- 2001 Dec;2(3):149-157.
The targeted RNA recombination was attempted to substitute the membrane (M) protein gene and part of the nucleocapsid (N) protein gene of mouse hepatitis virus with the corresponding sequences from... -
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- Isolation and Characterization of Human scFv Molecules Specific for Recombinant Human Heat Shock Protein (HSP) 70.1
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Baek HJ, Lee JS, Seo JS, Cha SH
- KMID: 2054238
- Immune Netw.
- 2004 Mar;4(1):7-15.
- doi: 10.4110/in.2004.4.1.7
BACKGROUND: The heat shock proteins (HSPs) play an important role in cellular protection mechanisms against physical or chemical stresses. In this study scFv antibodies specific for human HSP70.1 were isolated... -
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- High-Intensity Focused Ultrasound Therapy: an Overview for Radiologists
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Kim YS, Rhim H, Choi MJ, Lim HK, Choi D
- KMID: 1076454
- Korean J Radiol.
- 2008 Aug;9(4):291-302.
- doi: 10.3348/kjr.2008.9.4.291
High-intensity focused ultrasound therapy is a novel, emerging, therapeutic modality that uses ultrasound waves, propagated through tissue media, as carriers of energy. This completely non-invasive technology has great potential for... -
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- Recent technological updates and clinical applications of induced pluripotent stem cells
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Diecke S, Jung SM, Lee J, Ju JH
- KMID: 1794617
- Korean J Intern Med.
- 2014 Sep;29(5):547-557.
- doi: 10.3904/kjim.2014.29.5.547
Induced pluripotent stem cells (iPSCs) were first described in 2006 and have since emerged as a promising cell source for clinical applications. The rapid progression in iPSC technology is still... -
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