- Clinicopathologic Analysis of Epidermal Growth Factor Receptor Status in Non-small Cell Lung Cancer: Protein Expression, Gene Amplification and Survival Analysis
-
Lee S, Choi J, Jang SJ
- KMID: 1521612
- Korean J Pathol.
- 2007 Dec;41(6):387-392.
BACKGROUND: Abnormal over-expression or gene amplification of epidermal growth factor receptor (EGFR) is important in the prognosis of non-small cell lung cancer (NSCLC). We investigated the frequency of EGFR protein... -
- CITED
-
- Close
- SHARE
-
- Close
- Detection of MYC gene amplification in malignant lymphomas
-
Park CK, Lee CG, Lee JD
- KMID: 1064963
- J Korean Med Sci.
- 1998 Apr;13(2):159-164.
- doi: 10.3346/jkms.1998.13.2.159
The role of oncogene or tumor supressor gene in Epstein-Barr virus (EBV) associated malignant lymphomas (MLs) is poorly understood. We examined 36 MLs (21 EBV positive and 15 EBV... -
- CITED
-
- Close
- SHARE
-
- Close
- Loss of retinoblastoma gene and amplification of N-myc gene in retinoblastoma
-
Choi SW, Lee TW, Yang SW, Hong WS, Kim CM, Lee JO
- KMID: 1421955
- J Korean Med Sci.
- 1993 Feb;8(1):73-77.
- doi: 10.3346/jkms.1993.8.1.73
We have analyzed paired samples of genomic DNA from peripheral leukocyte and primary tumor tissue from nine patients with retinoblastoma (RB) and from two RB cell lines, WERI-Rb-1 and Y79,... -
- CITED
-
- Close
- SHARE
-
- Close
- Amplification and Overexpression of c-erbB-2 in Gastric Cancer
-
Jun SY, Chung HY, Lee SC, Huh TL, Yu W
- KMID: 2175010
- J Korean Cancer Assoc.
- 2000 Jun;32(3):467-475.
PURPOSE: We compared c-erbB-2 oncogene amplification and oncoprotein expression, trying to identify the biologic and prognostic significance of c-erbB-2 in adendegrees Carcinoma of the stomach. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue sections... -
- CITED
-
- Close
- SHARE
-
- Close
- Amplification and Overexpression of Cyclin D1 in Head and Neck Squamous Cell Carcinomas
-
Kim SH, Yeom BW
- KMID: 1920908
- Korean J Otolaryngol-Head Neck Surg.
- 1997 Dec;40(12):1801-1807.
BACKGROUND: Overexpression of the cell cycle control gene, cyclin D1 may, at least in some tumor types, provide a prognostic marker. Cyclin D1 is expressed during the G1 phase of... -
- CITED
-
- Close
- SHARE
-
- Close
- Gene Amplification and Overexpression in BPH by Means of One-step Real Time Quantitative PCR
-
Kim SW, Lee SJ, Lee JY, Lee CB, Kang SH, Cho YH, Yoon MS
- KMID: 1859357
- Korean J Androl.
- 2001 Dec;19(3):173-180.
PURPOSE: Gene amplification/overexpression of c-erbB2/neu is controversy in BPH by conventional detecting methods. To evaluate the amplification and overexpression of c-erbB2/neu gene in BPH we have used and validated a... -
- CITED
-
- Close
- SHARE
-
- Close
- Correlation between Amplification of c-myc Oncogene and Histophthologic Prognostic Factors in Endomentrial Cancer
-
Kim YT, Kim NK, Kim JW
- KMID: 2245018
- Korean J Gynecol Oncol Colposc.
- 1998 Sep;9(3):266-272.
The c-myc oncogene encodes a 62,000 daltons nuclear transcriptional factor and is believed to regulate cellular proliferation. Although its mechanism of action is incompletely understood, oncogene amplification followed by increased... -
- CITED
-
- Close
- SHARE
-
- Close
- Comparing Fluorescence In Situ Hybridization and Immunohistochemistry to Determine the HER-2/neu Status in Breast Carcinoma
-
Park K, Kim J, Lim S
- KMID: 1725912
- Korean J Pathol.
- 2002 Aug;36(4):243-248.
BACKGROUND: Identification of HER-2/neu status is important in predicting the response to specific chemotherapy in breast carcinoma patients and HER-2/neu status is associated with poor clinical outcome even with systemic... -
- CITED
-
- Close
- SHARE
-
- Close
- Prognostic Significance of HER2 Gene Amplification According to Stage of Breast Cancer
-
Kim YS, Won YS, Park KS, Song BJ, Kim JS, Oh SJ, Jeon HM, Jung SS, Park WC
- KMID: 1786878
- J Korean Med Sci.
- 2008 Jun;23(3):414-420.
- doi: 10.3346/jkms.2008.23.3.414
It is well known that the amplification of the HER2 gene is closely associated with poor prognosis of breast cancer. However, there is controversy about the clinical significance of HER2... -
- CITED
-
- Close
- SHARE
-
- Close
- Numerical aberrations of chromosome 17 and her2/neu gene amplification, her2/neu and p 53 protein expression in breast cancer
-
Han KT, Oh YH, Lim P
- KMID: 2119492
- J Korean Soc Plast Reconstr Surg.
- 1998 Dec;25(8):1416-1425.
Breast cancer is one of the leading causes of death attributable to cancer in women. In view of the limitations of conventional predictable factors of the breast cancer, additional second-generation... -
- CITED
-
- Close
- SHARE
-
- Close
- Comparison between L and E gene amplification analytical methods for human papillomavirus typing
-
Cho HB, Kim YJ, Kim KT
- KMID: 2173415
- J Gynecol Oncol.
- 2008 Dec;19(4):251-255.
- doi: 10.3802/jgo.2008.19.4.251
OBJECTIVE: L and E6/E7 gene amplification analyses were compared to identify human papillomavirus (HPV) infection and verify the HPV type, with the intent to minimize HPV typing errors. METHODS: L1 gene... -
- CITED
-
- Close
- SHARE
-
- Close
- The Analysis of HER-2/neu Gene Status and Correlation with Other Clinico-Pathologic Factors for Breast Cancer Using Tissue Microarray
-
Song CS, Kim SI, Park CH
- KMID: 2173498
- J Korean Breast Cancer Soc.
- 2004 Dec;7(4):251-255.
- doi: 10.4048/jkbcs.2004.7.4.251
PURPOSE: The main clinical significance of HER-2/neu gene amplification is derived from its use as (a) a prognostic indicator, (b) a predictive factor for the sensitivity to chemotherapy, and (c)... -
- CITED
-
- Close
- SHARE
-
- Close
- Correlation of EGFR and c-erbB-2 Gene Amplifications and Expression of COX-2 Protein in Invasive Ductal Carcinomas of the Breast
-
Hong BK, Kim BG, Cha SJ, Park SJ, Lim HM, Lee TJ
- KMID: 2210202
- J Korean Surg Soc.
- 2005 Oct;69(4):279-285.
PURPOSE: Abnormalities of epidermal growth factor receptor (EGFR) and c-erbB-2 have been actively investigated in breast cancer. Cyclooxygenase-2 (COX-2) seems to be involved in critical steps of cancer onset and... -
- CITED
-
- Close
- SHARE
-
- Close
- EGFR Gene Amplification and Protein Expression in Invasive Ductal Carcinoma of the Breast
-
Hwangbo W, Lee JH, Ahn S, Kim S, Park KH, Kim CH, Kim I
- KMID: 2277454
- Korean J Pathol.
- 2013 Apr;47(2):107-115.
BACKGROUND: The epidermal growth factor receptor (EGFR) is a surrogate marker for basal-like breast cancer. A recent study suggested that EGFR may be used as a target for breast cancer... -
- CITED
-
- Close
- SHARE
-
- Close
- Amplification and Overexpression of c-erbB2/neu in Bladder Tumor Using Real-time Quantitative PCR with TaqMan Detection System
-
Kim SW, Chung HS, Lee SJ, Lee JY, Cho YH, Yoon MS, Park YH
- KMID: 2292560
- Korean J Urol.
- 2001 Sep;42(9):924-933.
PURPOSE: C-erbB2/neu gene is potentially amplified and expressed in several tumors. In some cases, this genetic alteration seems to be a prognostic index of both overall survival and ... -
- CITED
-
- Close
- SHARE
-
- Close
- Malignant transformation in a Breast Adenomyoepithelioma Caused by Amplification of c-MYC: A Common pathway to Cancer in a Rare Entity
-
Febres-Aldana CA, Mejia-Mejia O, Krishnamurthy K, Mesko T, Poppiti R
- KMID: 2470885
- J Breast Cancer.
- 2020 Feb;23(1):93-99.
- doi: 10.4048/jbc.2020.23.e2
Breast adenomyoepitheliomas are composed of a biphasic proliferation of myoepithelial cells around small epithelial-lined spaces. Due to the rarity of adenomyoepitheliomas, the molecular data describing them are limited. Adenomyoepitheliomas are... -
- CITED
-
- Close
- SHARE
-
- Close
- Is Classification of Gastric Cancer According to Distinct Therapeutic Targets Applicable in Clinical Practice?
-
Kim KM
- KMID: 1775754
- Korean J Gastroenterol.
- 2013 Aug;62(2):140-141.
- doi: 10.4166/kjg.2013.62.2.140
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Chromogenic In Situ Hybridization Analysis to Determinate HER-2/neu Status in Breast Carcinoma
-
Kim JY, Choi KU, Jung YJ, Kwak HS, Bae YT
- KMID: 2096168
- J Korean Surg Soc.
- 2004 Jun;66(6):447-453.
PURPOSE: The determination of HER-2/neu gene amplification has become necessary for the selection of breast cancer patients to undergo anti-HER-2/neu therapy, using a humanized monoclonal antibody. Chromogenic in situ hybridization... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of Epidermal Growth Factor Receptor and the HER-2 Gene in Hormone Refractory Prostate Cancer
-
Cho KS, Kim DJ, Lee JS, Cho NH, Park K, Ham WS, Choi YD
- KMID: 2312032
- Korean J Urol.
- 2008 Jan;49(1):24-30.
PURPOSE: Amplification and mutation of the epidermal growth factor receptor(EGFR) and HER-2 genes were analyzed in the tissues of hormone refractory prostate cancer(HRPC) patients. MATERIALS AND METHODS: Gene amplifications of the... -
- CITED
-
- Close
- SHARE
-
- Close
- Clinicopathologic Implications of ALK Gene Copy Number Gain in Non-small Cell Lung Cancer
-
Yoo SB, Kim H, Xu X, Sun PL, Jin Y, Paik JH, Jheon S, Lee CT, Chung JH
- KMID: 2005739
- J Lung Cancer.
- 2011 Dec;10(2):87-93.
- doi: 10.6058/jlc.2011.10.2.87
PURPOSE: The anaplastic lymphoma kinase (ALK) gene is a potential molecular target in non-small cell lung carcinoma (NSCLC). The clinicopathologic implication of a change in the ALK gene copy number... -
- CITED
-
- Close
- SHARE
-
- Close
