- Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells
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Song JS, Cho KS, Yoon HK, Moon HS, Park SH
- KMID: 1115250
- Korean J Intern Med.
- 2005 Dec;20(4):275-283.
- doi: 10.3904/kjim.2005.20.4.275
BACKGROUND: Neutrophil elastase (NE) was found to increase the respiratory mucin gene, MUC5AC, although the molecular mechanisms of this process remain unknown. We attempted to determine the signal transduction pathway... -
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- Synergistic Effect of Interleukin-6 and Hyaluronic Acid on Cell Migration and ERK Activation in Human Keratinocytes
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Choi JH, Jun JH, Kim JH, Sung HJ, Lee JH
- KMID: 2151415
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S210-S216.
- doi: 10.3346/jkms.2014.29.S3.S210
Wound healing is initiated and progressed by complex integrated process of cellular, physiologic, and biochemical events, such as inflammation, cell migration and proliferation. Interleukin 6 (IL-6) is a multifunctional cytokine,... -
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- Autocrine Extracellular Signal-regulated Kinase Activation in Normal Human Keratinocytes is not Interrupted by Calcium Triggering and is Involved in the Control of Cell Cycle at the Early Stage of Calciuminduced Differentiation
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Park GT, Kim HY, Kim EK, Yang JM
- KMID: 1713190
- J Korean Med Sci.
- 2007 Apr;22(2):290-297.
- doi: 10.3346/jkms.2007.22.2.290
Normal human epidermal keratinocytes (NHEK) respond to the autocrine activated extracellular signal-regulated kinase (ERK) signaling pathway, which contributes to the survival of keratinocytes. However, during the condition of calcium-induced differentiation,... -
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- Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells
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Kim BS, Kang HJ, Park JY, Lee J
- KMID: 2155393
- Exp Mol Med.
- 2015 Jan;47(1):e128.
- doi: 10.1038/emm.2014.95
Fucoidan has attracted attention as a potential drug because of its biological activities, which include osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of fucoidan in human alveolar... -
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- Sphingosine 1-Phosphate Triggers Apoptotic Signal for B16 Melanoma Cells via ERK and Caspase Activation
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Shin JH, Choi GS, Kang WH, Myung KB
- KMID: 1713191
- J Korean Med Sci.
- 2007 Apr;22(2):298-304.
- doi: 10.3346/jkms.2007.22.2.298
The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), recently was reported to induce apoptosis of some cancer cells and neurons, although it generally known to exert mitogenic and antiapoptotic effects. In... -
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- p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells
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Ko J, Yun CY, Lee JS, Kim JH, Kim IS
- KMID: 1094653
- Exp Mol Med.
- 2007 Apr;39(2):129-138.
9-cis-retinoic acid (9CRA) plays an important role in the immune response; this includes cytokine production and cell migration. We have previously demonstrated that 9CRA increases expression of chemokine receptors CCR1... -
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- Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway
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Yang L, Zou X, Liang Q, Chen H, Feng J, Yan L, Wang Z, Zhou D, Li S, Yao S, Zheng Z
- KMID: 1103682
- Exp Mol Med.
- 2007 Feb;39(1):65-73.
Cardiomyocyte hypertrophy is a major cause of morbidity and mortality worldwide. The aim of this study is to determine the effects of sodium tanshinone IIA sulfonate (STS) on cardiomyocyte hypertrophy... -
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- Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway
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Moon BS, Yoon JY, Kim MY, Lee SH, Choi T, Choi KY
- KMID: 1109434
- Exp Mol Med.
- 2009 Feb;41(2):116-125.
- doi: 10.3858/emm.2009.41.2.014
Bone morphogenic protein 4 (BMP4), a member of the TGF-beta superfamily, induced neural differentiation of neural stem cells (NSCs) grown in a medium containing basic fibroblast growth factor (bFGF). The... -
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- Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo
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Kim EC, Kim SH, Piao SJ, Kim TJ, Bae K, Kim HS, Hong SS, Lee BI, Nam M
- KMID: 2164486
- J Korean Med Sci.
- 2015 Jul;30(7):979-987.
- doi: 10.3346/jkms.2015.30.7.979
Angiogenesis, the formation of new blood vessels, is critical for tumor growth and metastasis. Notably, tumors themselves can lead to angiogenesis by inducing vascular endothelial growth factor (VEGF), which is... -
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- Duration and Magnitude of Extracellular Signal-Regulated Protein Kinase Phosphorylation Determine Adipogenesis or Osteogenesis in Human Bone Marrow-Derived Stem Cells
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Jung HS, Kim YH, Lee JW
- KMID: 1106452
- Yonsei Med J.
- 2011 Jan;52(1):165-172.
- doi: 10.3349/ymj.2011.52.1.165
PURPOSE: Imbalances between osteogenic and adipogenic differentiation leads to diseases such as osteoporosis. The aim of our study was to demonstrate the differences in extracellular signal-regulated kinase (ERK) phosphorylation during... -
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- Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway
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Park MH, Lee DH
- KMID: 1103592
- Exp Mol Med.
- 2008 Feb;40(1):92-97.
- doi: 10.3858/emm.2008.40.1.92
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and... -
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