- Thalidomide Accelerates the Degradation of Extracellular Matrix in Rat Hepatic Cirrhosis via Down-Regulation of Transforming Growth Factor-beta1
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Lv P, Meng Q, Liu J, Wang C
- KMID: 2345885
- Yonsei Med J.
- 2015 Nov;56(6):1572-1581.
- doi: 10.3349/ymj.2015.56.6.1572
PURPOSE: The degradation of the extracellular matrix has been shown to play an important role in the treatment of hepatic cirrhosis. In this study, the effect of thalidomide on the... -
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- The Increased Expression of Matrix Metalloproteinases Associated with Elastin Degradation and Fibrosis of the Ligamentum Flavum in Patients with Lumbar Spinal Stenosis
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Park JB, Kong CG, Suhl KH, Chang ED, Riew KD
- KMID: 1122637
- Clin Orthop Surg.
- 2009 Jun;1(2):81-89.
- doi: 10.4055/cios.2009.1.2.81
BACKGROUND: One of the characteristics of spinal stenosis is elastin degradation and fibrosis of the extracellular matrix of the ligamentum flavum. However, there have been no investigations to determine which... -
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- Relaxin Modulates the Expression of MMPs and TIMPs in Fibroblasts of Patients with Carpal Tunnel Syndrome
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Kang YM, Lee HM, Moon SH, Kang H, Choi YR
- KMID: 2427132
- Yonsei Med J.
- 2017 Mar;58(2):415-422.
- doi: 10.3349/ymj.2017.58.2.415
PURPOSE: The aim of this study was to investigate the anti-fibrotic effect of relaxin in subsynovial fibroblasts activated by transforming growth factor beta (TGF-β). MATERIALS AND METHODS: To test the anti-fibrotic... -
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- Regulatory Role of Hypoxia Inducible Factor in the Biological Behavior of Nucleus Pulposus Cells
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Li H, Liang CZ, Chen QX
- KMID: 2158211
- Yonsei Med J.
- 2013 Jul;54(4):807-812.
- doi: 10.3349/ymj.2013.54.4.807
Intervertebral disc (IVD) degeneration is implicated as a major cause of low back pain. The alternated phenotypes, reduced cell survival, decreased metabolic activity, loss of matrix production and dystrophic mineralization... -
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- In vitro model of atherosclerosis using coculture of arterial wall cells and macrophage
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Wada Y, Sugiyama A, Kohro T, Kobayashi , Takeya M, Naito M, Kodama T
- KMID: 1114562
- Yonsei Med J.
- 2000 Dec;41(6):740-755.
- doi: 10.3349/ymj.2000.41.6.740
In order to determine the precise mechanism of the interactions between different types of cells, which are common phenomena in tissues and organs, the importance of coculture techniques are becoming... -
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- c-Jun N-terminal kinase is involved in motility of endothelial cell
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Shin EY, Kim SY, Kim EG
- KMID: 1457542
- Exp Mol Med.
- 2001 Dec;33(4):276-283.
Cell motility is essential for a wide range of cellular activities including anigogenesis as well as metastasis of tumor cells. Ras has been implicated in cell migration and invasion, and... -
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- Chronic liver injury, TGF-beta, and cancer
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Bissell DM
- KMID: 1457528
- Exp Mol Med.
- 2001 Dec;33(4):179-190.
Cells termed myofibroblasts are prominent in the injury response of all epithelial tissues. They exhibit proliferation, migration, production of collagen and other extracellular matrix (ECM) molecules, and contraction, all for... -
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- Expression of Cell Cycle Regulators During Smooth Muscle Cell Proliferation After Balloon Catheter Injury of Rat Artery
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Chung JK, Lee T, Jung IM, Kim YK, Min SK, Suh JW, Kim SJ
- KMID: 1786807
- J Korean Med Sci.
- 2004 Jun;19(3):327-332.
- doi: 10.3346/jkms.2004.19.3.327
Intimal hyperplasia is defined as the abnormal migration and proliferation of vascular smooth muscle cells (VSMCs) with deposition of extracellular matrix. However, the cell cycle regulatory mechanisms of injury-induced VSMC... -
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