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In vitro model of atherosclerosis using coculture of arterial wall cells and macrophage

Wada Y, Sugiyama A, Kohro T, Kobayashi , Takeya M, Naito M, Kodama T

In order to determine the precise mechanism of the interactions between different types of cells, which are common phenomena in tissues and organs, the importance of coculture techniques are becoming...
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Activated platelets induce secretion of interleukin-1beta, monocyte chemotactic protein-1, and macrophage inflammatory protein-1alpha and surface expression of intercellular adhesion molecule-1 on cultured endothelial cells

Cha JK, Jeong MH, Bae HR, Han JY, Jeong SJ, Jin HJ, Lim YJ, Kim SH, Kim JW

Atherosclerosis is an inflammatory disease. Platelet-endothelium interaction plays an important role in the pathophysiology of atherogenesis. We investigated the role of activated platelets for secretion of interleukin (IL)-1beta, monocyte chemotactic...
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Receptors for Treponema pallidum Attachment to the Surface and Matrix Proteins of Cultured Human Dermal Microvascular Endothelial Cells

Lee JH, Choi HJ, Jung J, Lee MG, Lee JB, Lee KH

Pathogenicity of Treponema pallidum may depend upon the binding of Treponema pallidum to matrix proteins, especially to fibronectin. Infectious organism or cell to matrix interactions are mediated by a family...
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Behcet's disease sera containing antiendothelial cell antibodies promote adhesion of T lymphocytes to cultured human dermal microvascular endothelial cells

Lee KH, Chung HS, Bang D, Lee S

Antiendothelial cell antibodies (AECA) have been detected in the sera of patients of autoimmune diseases showing vasculitis. Using IgM-ELISA, we found AECA in 42 (56%) of 75 sera...
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Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells

Kim SA, Hong KJ

  • KMID: 755077
  • Exp Mol Med.
  • 2000 Sep;32(3):135-140.
Thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, inhibits neovascularization and is implicated in the regression of tumor growth and metastasis. We found that the synthesis of TSP-1 in...
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Viability of cells in cryopreserved canine cardiovascular organs for transplantation

Park JC, Sung HJ, Lee DH, Park YH, Cho BK, Suh H

To determine applicability of the cryopreservation procedure for vessel grafts, the viability of endothelial cells (ECs) among the whole cells in three kinds of organs artery, vein, trachea in mongrel...
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Morphine Attenuates Endothelial Cell Adhesion Molecules Induced by the Supernatant of LPS-Stimulated Colon Cancer Cells

Min TJ, Park SH, Ji YH, Lee YS, Kim TW, Kim JH, Kim WY, Park YC

A large reservoir of bacterial lipopolysaccharide (LPS) is available in the colon and this could promote colon cancer metastasis by enhancing tumor cell adhesion, intravasation, and extravasation. Furthermore, adhesion molecules...
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Biomedical significance of endothelial cell specific growth factor, angiopoietin

Koh GY, Kim I, Kwak HJ, Yun MJ, Leem JC

  • KMID: 1093591
  • Exp Mol Med.
  • 2002 Mar;34(1):1-11.
Until recently, vascular endothelial growth factor (VEGF) was the only growth factor proven to be specific and critical for blood vessel formation. Other long-known factors, such as the fibroblast growth...
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Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells

Chung HK, Lee IK, Kang HK, Suh JM, Kim H, Park KC, Kim DW, Kim YK, Ro HK, Shong MH

  • KMID: 1121099
  • Exp Mol Med.
  • 2002 Dec;34(6):451-461.
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known as statins, are widely used for primary and secondary prevention of coronary artery atherosclerosis. Pathogenesis of atherosclerosis is multistep processes where...
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Purification and characterization of recombinant murine endostatin in E. coli

You WK, So SH, Lee H, Park SY, Yoon MR, Chang SI, Kim HK, Joe YA, Hong YK, Chung SI

  • KMID: 1029927
  • Exp Mol Med.
  • 1999 Dec;31(4):197-202.
Endostatin, a carboxyl-terminal fragment of collagen XVIII is known as an anti-angiogenic agent, that specifically inhibits the proliferation of endothelial cell and the growth of several primary tumor....
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Vibrio vulnificus cytolysin induces hyperadhesiveness of pulmonary endothelial cells for neutrophils through endothelial P-selectin: a mechanism for pulmonary damage by Vibrio vulnificus cytolysin

Kim BS, Kim JS

  • KMID: 931882
  • Exp Mol Med.
  • 2002 Sep;34(4):308-312.
Vibrio vulnificus cytolysin forms transmembrane pores that are permeable to calcium ions in pulmonary endothelial cells, and has been suggested as an important virulence factor that sequestrate neutrophils primarily...
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Shear stress stimulates phosphorylation of protein kinase A substrate proteins including endothelial nitric oxide synthase in endothelial cells

Boo YC

  • KMID: 1105278
  • Exp Mol Med.
  • 2006 Feb;38(1):63-71.
Fluid shear stress plays a critical role in vascular health and disease. While protein kinase A (PKA) has been implicated in shear-stimulated signaling events in endothelial cells, it remains unclear...
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Effect of Ultraviolet Light on the Expression of Adhesion Molecules and T Lymphocyte Adhesion to Human Dermal Microvascular Endothelial Cells

Chung KY, Chang NS, Park YK, Lee KH

In order to determine the effect of ultraviolet radiation (UVR) on the cell adhesion molecules expressed in human dermal microvascular endothelial cells (HDMEC), the cells were exposed to varying UVR...
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Morphine Postconditioning Attenuates ICAM-1 Expression on Endothelial Cells

Min TJ, Kim JI, Kim JH, Noh KH, Kim TW, Kim WY, Lee YS, Park YC

The purpose of this study is to determine 1) whether morphine postconditiong (MPostC) can attenuate the intercellular adhesion molecules-1 (ICAM-1) expression after reoxygenation injury and 2) the subtype(s) of the...
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Propofol and Aminophylline Antagonize Each Other During the Mobilization of Intracellular Calcium in Human Umbilical Vein Endothelial Cells

Son HJ, Lim YC, Ha KS, Kang SS, Cheong IY, Lee SJ, Park SW, Hwang BM

This study examined whether propofol and aminophylline affect the mobilization of intracellular calcium in human umbilical vein endothelial cells. Intracellular calcium was measured using laser scanning confocal microscopy. Cultured and...
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Potential Role of Homer-2a on Cutaneous Vascular Anomaly

Kim JT, Park SH, Kim SK, Kwon EY, Do MH, Hwang TH

Homer protein was identified based on its rapid induction in rat hippocampal granule cell neurons following excitatory synaptic activity. Although the presence of the Homer gene in the peripheral...
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Role of Hepatic Stellate Cells in the Angiogenesis of Hepatoma

Jung JO, Gwak GY, Lim YS, Kim CY, Lee HS

  • KMID: 772536
  • Korean J Gastroenterol.
  • 2003 Aug;42(2):142-148.
BACKGROUND/AIMS: Hepatic stellate cells (HSCs) in the hepatocellular carcinoma are responsible for tumor encapsulation as a host defense mechanism. Recently, it was suggested that HSCs might play an important...
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Expression and Regulation of Endothelial Nitric Oxide Synthase by Vascular Endothelial Growth Factor in ECV 304 Cells

Park JS, Hong GR, Baek SW, Shin DG, Kim YJ, Shim BS

Nitric oxide (NO) seems to play a pivotal role in the vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation. This study was designed to investigate the role and intracellular signal...
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c-Jun N-terminal kinase is involved in motility of endothelial cell

Shin EY, Kim SY, Kim EG

  • KMID: 1457542
  • Exp Mol Med.
  • 2001 Dec;33(4):276-283.
Cell motility is essential for a wide range of cellular activities including anigogenesis as well as metastasis of tumor cells. Ras has been implicated in cell migration and invasion, and...
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Tissue Responses to Stent Grafts with Endo-Exo-Skeleton for Saccular Abdominal Aortic Aneurysms in a Canine Model

Kim YI, Choi YH, Chung JW, Kim HC, So YH, Kim HB, Min SK, Park JH

OBJECTIVE: We evaluated the effect of close contact between the stent and the graft on the induction of endothelial covering on the stent graft placed over an aneurysm. MATERIALS AND METHODS:...
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