- Erythropoietin and autoimmune neuroinflammation: lessons from experimental autoimmune encephalomyelitis and experimental autoimmune neuritis
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Shin T, Ahn M, Moon C, Kim S
- KMID: 2133907
- Anat Cell Biol.
- 2012 Dec;45(4):215-220.
- doi: 10.5115/acb.2012.45.4.215
Erythropoietin (EPO) is known to have numerous biological functions. While its primary function is during haematopoiesis, recent studies have shown that EPO plays important role in cytoprotection, immunomodulation, and antiapoptosis.... -
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- A Case of Relapsed Acute Disseminated Encephalomyelitis
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Park JH, Lee JS, Coe CJ, Yoon CS
- KMID: 2177140
- J Korean Child Neurol Soc.
- 1998 May;5(2):377-382.
Acute disseminated encephalomyelitis(ADEM) and acute relapsing disseminated encephalomyelitis(ARDEM) are representative demyelination diseases that occur among young children with a fulminant onset similar to encephalitis or meningitis. The diseases often occur... -
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- Effects of Dexamethasone on Neurogenic Bladder in Experimental Autoimmune Encephalomyelitis Rat
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Park JH, Ko YJ, Choi ES, Kim HW, Kim JH, Park SH
- KMID: 2323906
- J Korean Acad Rehabil Med.
- 2003 Oct;27(5):682-687.
OBJECTIVE: We studied effects of dexamethasone on neurogenic bladder and paralysis in experimental autoimmune encephalomyelitis (EAE) rat model for multiple sclerosis. METHOD: Thirty-five female Lewis rats were used in the... -
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- Mechanism of experimental autoimmune encephalomyelitis in Lewis rats: recent insights from macrophages
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Shin T, Ahn M, Matsumoto
- KMID: 2046740
- Anat Cell Biol.
- 2012 Sep;45(3):141-148.
- doi: 10.5115/acb.2012.45.3.141
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is an acute monophasic paralytic central nervous system disease, in which most rats spontaneously recover from paralysis. EAE in Lewis rats is induced... -
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- Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis
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Ahn M, Kang S, Park C, Kim J, Jung K, Yang M, Kim SH, Moon C, Shin T
- KMID: 2368754
- Korean J Vet Res.
- 2016 Jun;56(2):117-120.
- doi: 10.14405/kjvr.2016.56.2.117
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by transient paralysis followed by recovery. To evaluate whether transient paralysis in EAE affects bone density, tibiae of EAE rats were... -
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- Immunohistochemical Localization of Bcl-2 in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis
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Moon CJ, Lee YD, Shin TK
- KMID: 1097344
- J Vet Sci.
- 2002 Dec;3(4):279-283.
We examined the localization of the anti-apoptotic molecule Bcl-2 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis (EAE). Western blot analysis showed that Bcl-2 was constitutively expressed... -
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- Melatonin ameliorates autoimmune encephalomyelitis through suppression of intercellular adhesion molecule-1
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Kang JC, Ahn M, Kim YS, Moon C, Lee Y, Wie MB, Lee YJ, Shin T
- KMID: 1103513
- J Vet Sci.
- 2001 Aug;2(2):85-89.
Melatonin (N-acetyl-5-methoxytryptamine), a pineal neurohormone, is a hydroxyl radical scavenger and antioxidant, and plays an important role in the immune system. We studied the effect of exogenous melatonin on the... -
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- Amelioration of experimental autoimmune encephalomyelitis by Ishige okamurae
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Ahn M, Kim J, Yang W, Choi Y, Ekanayake , Ko H, Jee Y, Shin T
- KMID: 2430197
- Anat Cell Biol.
- 2018 Dec;51(4):292-298.
- doi: 10.5115/acb.2018.51.4.292
Experimental autoimmune encephalomyelitis (EAE) is a T-cell-mediated autoimmune central nervous system disease characterized by inflammation with oxidative stress. The aim of this study was to evaluate an anti-inflammatory effect of... -
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- Experimental autoimmune encephalomyelitis in cynomolgus monkeys
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Nam KH
- KMID: 1094651
- J Vet Sci.
- 2000 Dec;1(2):127-131.
Experimental autoimmune encephalomyelitis was induced in macaques. T cell clones infiltrated into the brain lesion area were compared with those in blood. Intradermal immunization of macaques with brain white matter... -
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- Embryonic Intermediate Filaments, Nestin and Vimentin, Expression in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis
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Shin TK, Lee YD, Sim KB
- KMID: 1099815
- J Vet Sci.
- 2003 Apr;4(1):9-13.
Intermediate filaments, including nestin and vimentin, are found in specific cell types in central nervous system (CNS) tissues, particularly immature glial cells and multipotent progenitor cells. In the present study,... -
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- Increased expression of neuronal nitric oxide synthase in astrocytes and macrophages in the spinal cord of Lewis rats with autoimmune encephalomyelitis
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Shin T
- KMID: 1119215
- J Vet Sci.
- 2001 Dec;2(3):195-199.
Neuronal nitric oxide synthase (nNOS) is constitutively expressed in neurons of the central nervous system, where it plays a physiological role in neurotransmission. In this study, we examined the functional... -
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- The Anti-Inflammatory Effects of Oral-Formulated Tacrolimus in Mice with Experimental Autoimmune Encephalomyelitis
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Kim MJ, Sung JJ, Kim SH, Kim JM, Jeon GS, Mun SK, Ahn SW
- KMID: 2385958
- J Korean Med Sci.
- 2017 Sep;32(9):1502-1507.
- doi: 10.3346/jkms.2017.32.9.1502
Multiple sclerosis (MS) is a T-lymphocyte-mediated autoimmune disease that is characterized by inflammation in the central nervous system (CNS). Although many disease-modifying therapies (DMTs) are presumed effective in patients with... -
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- Immunopathogenic Mechanism Based Treatment of Multiple Sclerosis
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Cho JY, Kim HJ
- KMID: 2053703
- Hanyang Med Rev.
- 2006 Feb;26(1):69-76.
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination, focal infiltration of inflammatory cells and axonal injury, which leads to loss of... -
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- Glatiramer acetate inhibits the activation of NFkappaB in the CNS of experimental autoimmune encephalomyelitis
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Hwang I, Ha D, Kim DS, Joo H, Jee Y
- KMID: 1991802
- Korean J Vet Res.
- 2011 Sep;51(3):217-225.
Glatiramer acetate (GA; Copaxone) has been shown to be effective in preventing and suppressing experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). It has been recently shown... -
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- Increased expression of galectin-9 in experimental autoimmune encephalomyelitis
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Cho J, Bing SJ, Kim A, Yu HS, Lim YK, Shin T, Choi J, Jee Y
- KMID: 2307885
- Korean J Vet Res.
- 2014 Dec;54(4):209-218.
- doi: 10.14405/kjvr.2014.54.4.209
Experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis (MS), reflects pathophysiologic steps in MS such as the influence of T cells and antibodies reactive to the myelin... -
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- A study of experimental autoimmune encephalomyelitis in dogs as a disease model for canine necrotizing encephalitis
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Moon JH, Jung HW, Lee HC, Jeon JH, Kim NH, Sur JH, Ha J, Jung DI
- KMID: 2164530
- J Vet Sci.
- 2015 Jun;16(2):203-211.
- doi: 10.4142/jvs.2015.16.2.203
In the present study, the use of dogs with experimental autoimmune encephalomyelitis (EAE) as a disease model for necrotizing encephalitis (NE) was assessed. Twelve healthy dogs were included in this... -
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- Therapeutic Efficacy of Mesenchymal Stem Cells and Mesenchymal Stem Cells-derived Neural Progenitors in Experimental Autoimmune Encephalomyelitis
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Nasri F, Mohtasebi , Hashemi E, Zarrabi M, Gholijani , Sarvestani EK
- KMID: 2413502
- Int J Stem Cells.
- 2018 Jun;11(1):68-77.
- doi: 10.15283/ijsc17052
BACKGROUND AND OBJECTIVES: The goal of treatment for MS is to reduce the inflammation and induce the regeneration of degenerated axons. Considering the anti-inflammatory and regenerative capacity of mesenchymal stem... -
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- Sex-specific regulation of immune responses by PPARs
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Park HJ, Choi JM
- KMID: 2389292
- Exp Mol Med.
- 2017 Aug;49(8):e364.
- doi: 10.1038/emm.2017.102
The prevalence of autoimmune, infectious and metabolic diseases is different for men and women owing to the respective ability of their immune systems to respond to self and foreign antigens.... -
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- Expression of Erythropoietin in the Spinal Cord of Lewis Rats with Experimental Autoimmune Encephalomyelitis
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Kang SY, Kang JH, Choi JC, Lee JS, Lee CS, Shin T
- KMID: 2400398
- J Clin Neurol.
- 2009 Mar;5(1):39-45.
BACKGROUND AND PURPOSE: Erythropoietin (Epo), originally recognized for its central role in erythropoiesis, has been shown to improve the outcomes in patients with various neurological disorders. The aim of this... -
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- The Effects of Intradermal Vaccination with DNA Encoding for the T-cell Receptor on the Induction of Experimental Autoimmune Encephalomyelitis in B10.PL Mice
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Kwon SS, Kim N, Yoo TJ
- KMID: 2157759
- J Korean Med Sci.
- 2005 Dec;20(6):1039-1045.
- doi: 10.3346/jkms.2005.20.6.1039
Intradermal gene administration was found to induce a more profound immune response than direct intramusclular gene injection. We performed intradermal vaccination of B10.PL mice with DNA encoding for the V... -
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