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Antifungal Resistance in Yeasts and Filamentous Fungi

Shin JH

The incidence of invasive fungal infection has increased worldwide along with the increasing population of high risk patients. Recently developed antifungal agents, such as second-generation triazoles and echinocandins, provide the...
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Systemic Antifungal Agents and Clinical Application

Jun JB, Choi SH, Ryu JS, Woo JH

  • KMID: 1596125
  • Korean J Med Mycol.
  • 2005 Mar;10(1):1-10.
In the past, even two decades ago, it was not easy for the physicians to diagnose the systemic fungal infection especially in immuno-compromised host. However, as malignant neoplasm and organ...
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Current and Emerging Antifungal Agents in Japan

Yamaguchi

  • KMID: 1517382
  • Korean J Med Mycol.
  • 2003 Jun;8(2):35-42.
Currently available antifungal agents for the treatment of systemic fungal infections in Japan are smaller in number than those in the United States and Europe and probably in Korea. Therefore,...
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Systemic Antifungal Agents

Woo JH, Chung DR, Ryu J

  • KMID: 1549919
  • Korean J Med Mycol.
  • 1997 Dec;2(2):110-122.
There is an increasing tendency of systemic fungal infection because of increase in the number of immunocomproised patients such as the patients receiving anticancer chmotherapy or organ transplant. The frequency...
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Current Usage and Prospect of New Antifungal agents in Korea

Kim SI, Kang MW

The incidence of invasive fungal infections has been increased worldwide along with the increasing population at high risk for fungal infection. However, no data is available for the current status...
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In Vitro Susceptibilities of Clinical Isolates of Aspergillus Species against Echinocandins

Lee JS, Shin JH, Jung SI, Park KH, Choi HW, Cho D, Kee SJ, Kim SH, Shin MG, Suh SP, Ryang DW

  • KMID: 2170202
  • Infect Chemother.
  • 2007 Jun;39(3):151-158.
BACKGROUND: Echinocandins are a new class of antifungal agents with potent in vitro and in vivo activities against Aspergillus species. We investigated the in vitro activity of caspofungin and micafungin...
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A Case of Candida pelliculosa Prosthetic Valve Endocarditis Treated with Anidulafungin and Valve Replacement

Kang SJ, Jang MO, Jang HC, Jung SI, Shin JH, Park KH

Candida pelliculosa is a rare cause of human infection. In this report, we describe a case of infective endocarditis caused by C. pelliculosa in a patient with a prosthetic heart...
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Peritonitis due to Aspergillus niger in Two Continuous Ambulatory Peritoneal Dialysis Patients

Cho HJ, Yoon K, Kim JY, Kim JS, Park SW, Wang JK, Lee YM, Lee JE, Pyo HJ, Kwon YJ

  • KMID: 2253077
  • Korean J Nephrol.
  • 2010 Mar;29(2):280-284.
Aspergillus peritonitis is a rare but serious cause of peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients. We report 2 cases of peritonitis caused by Aspergillus niger in CAPD which...
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Identification and Antifungal Susceptibility Profiles of Cyberlindnera fabianii in Korea

Park JH, Oh J, Sang H, Shrestha B, Lee H, Koo J, Cho SI, Choi JS, Lee MH, Kim J, Sung GH

Invasive fungal infections caused by Cyberlindnera fabianii have recently increased. However, biochemical kits such as API 20 C AUX and Vitek-2C have misidentified this species as other Candida spp. such...
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High-dose caspofungin salvage in a very-low-birth-weight infant with refractory candidemia

Seo ES, Park GH, Kim SM, Jung HA, Kim BK

Candidiasis is one of the most common causes of late-onset infection among very-low-birth-weight infants (VLBW) in most neonatal intensive care units and is associated with significant morbidity and mortality. Standard...
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In Vitro Susceptibilities to Caspofungin and Micafungin of Clinical Isolates of Candida Species

Choi HW, Shin JH, Lee JS, Cho D, Shin MG, Suh SP, Ryang DW

BACKGROUND: Caspofungin and micafungin are echinochandins with potent activities against Candida species. However, in vitro susceptibility to these agents of clinical Candida isolates in Korea has not been fully surveyed....
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Voriconazole plus caspofungin for treatment of invasive fungal infection in children with acute leukemia

Lee KH, Lim YT, Hah JO, Kim YK, Lee CH, Lee JM

BACKGROUND: Invasive fungal infections (IFIs) are a life-threatening problem in immunocompromised patients. Despite timely diagnosis and appropriate antifungal therapy, clinical outcomes of IFIs remain unsatisfactory, necessitating treatment with a combination...
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Species Distribution and Antifungal Susceptibility of Yeasts Isolated from Ear Specimens

Kwon YJ, Byun SA, Choi MJ, Won EJ, Kim SH, Shin JH

BACKGROUND: Candida auris was first isolated from the ears of Japanese and Korean patients. However, the prevalence of yeast isolates from ear cultures and their antifungal susceptibility profiles in these...
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A Case of Delayed Onset Chest Wall Abscess after Candidemia

Yoo H, Chung CS, Jung SW, Moh IH, Song W, Lee J

Recently, the incidence of candida infection has increased. Candida species often show hematogenous spread to the kidney, brain, heart, and eyes. And delayed onset of hematogenous spread is relatively rare....
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A Fatal Case of Candida orthopsilosis Fungemia

Choi HJ, Shin JH, Park KH, Shin MG, Suh SP, Ryang DW

Candida orthopsilosis is a recently described Candida species phenotypically indistinguishable from Candida parapsilosis. This new species can be identified only by using molecular methods. We describe here a fatal case...
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Catheter-related Candidemia Caused by Candida haemulonii in a Patient in Long-term Hospital Care

Kim S, Ko KS, Moon SY, Lee MS, Lee MY, Son JS

Candida haemulonii, one of the non-albicans Candida species, is an emerging yeast pathogen that is known to be resistant to amphotericin B and other antifungal agents such as azoles. These...
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Are Systemic Voriconazole and Caspofungin Ototoxic? An Experimental Study with Rats

Aydin E, Aydogan F, Tastan E, Iriz A, Karaca G, Haberal Can I

OBJECTIVES: To determine whether systemic administration of voriconazole and caspofungin causes ototoxicity. METHODS: This study was conducted on 32 healthy male Wistar albino rats. The baseline auditory brainstem response (ABR) thresholds...
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Efficacy and Safety of Micafungin for Prophylaxis of Invasive Fungal Infection in Hematopoietic Stem Cell Transplantation Recipients

Kim SH, Lee DG, Choi SM, Kwon JC, Park SH, Choi JH, Yoo JH, Lee SE, Cho BS, Kim YJ, Lee S, Kim HJ, Min CK, Cho SG, Kim DW, Lee JW, Min WS, Park JW

BACKGROUND: Micafungin, a potent inhibitor of 1,3-beta-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well...
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In vitro Evaluation of Antibiotic Lock Technique for the Treatment of Candida albicans, C. glabrata, and C. tropicalis Biofilms

Ko KS, Lee JY, Song JH, Peck KR

Candidaemia associated with intravascular catheter-associated infections is of great concern due to the resulting high morbidity and mortality. The antibiotic lock technique (ALT) was previously introduced to treat catheter-associated bacterial...
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