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Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis

Osani MC, Bannuru RR

About 21% of adults with osteoarthritis (OA) are diagnosed with concomitant depression in addition to chronic pain. Duloxetine, an anti-depressant medication, has been recently approved for managing Knee OA. We...
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Combined Use of Duloxetine and Olanzapine in the Treatment of Urologic Chronic Pelvic Pain Syndromes Refractory to Conventional Treatment: A Case Report

Bi B, Shan L, Zhou D

Patients with urologic chronic pelvic pain syndromes (UCPPS) report interstitial cystitis/bladder pain syndrome and/or chronic prostatitis/chronic pelvic pain syndrome. The pathogenesis of these syndromes remains unclear and there is currently...
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Duloxetine-Induced Liver Injury in Patients with Major Depressive Disorder

Kang SG, Park YM, Lee HJ, Yoon B

  • KMID: 2316095
  • Psychiatry Investig.
  • 2011 Sep;8(3):269-271.
Duloxetine is a balanced serotonin-norepinephrine reuptake inhibitor. Duloxetine-induced liver injury in patients with preexisting liver disease or chronic alcohol use is known. However, we have found that duloxetine can also...
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Two Cases of Hyponatremia Induced by Duloxetine for Treating Peripheral Neuropathic Pain

Ra JE, Hwang IK, Seo BS, Lee JK, Mok YM, Kim H, Lee JE

  • KMID: 2264795
  • Korean J Med.
  • 2012 Dec;83(6):813-816.
Duloxetine is a balanced serotonin and norepinephrine reuptake inhibitor available for treating peripheral neuropathic pain. The occurrence of hyponatremia as an adverse event of duloxetine treatment, but it has not...
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New Frontiers in the Treatment of Overactive Bladder

Kim DK, Chancellor MB

  • KMID: 2330480
  • J Korean Continence Soc.
  • 2003 Jun;7(1):1-8.
No abstract available.
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Acute Dystonia after Using Single Dose Duloxetine: Case Report

Karakas Ugurlu G, Onen S, Bayindirli D, Caykoylu A

  • KMID: 2316253
  • Psychiatry Investig.
  • 2013 Mar;10(1):95-97.
Duloxetine is a balanced and potent serotonin and noradrenaline reuptake inhibitor which is known to be effective in depression and anxiety disorders. The common adverse effects include dry mouth, nausea,...
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A Case of Serotonin Syndrome Induced by Fluoxetine and Duloxetine Independently in a Same Patient

You S, Noh JS

  • KMID: 2287474
  • Korean J Psychopharmacol.
  • 2012 Apr;23(2):74-77.
Here we report a case of serotonin syndrome caused by fluoxetine 20 mg and duloxetine 60 mg independently eight week apart. A 65-year old man developed fever, agitation and change...
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Rapid-Onset Hyponatremia Induced by Duloxetine in a Middle-Aged Male with Depression and Somatic Symptoms

Choi JS, Lee HW, Lee JY, Jung HY

  • KMID: 2316166
  • Psychiatry Investig.
  • 2012 Mar;9(1):83-84.
Duloxetine is a relatively balanced selective serotonin and noradrenaline reuptake inhibitor. We report a case of hyponatremia induced by duloxetine developed rapidly after starting the medication in a middle-aged male...
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Overactive Bladder Successfully Treated with Duloxetine in a Female Adolescent

Wang SM, Lee HK, Kweon YS, Lee CT, Lee KU

Overactive bladder (OAB) is defined as urgency, usually with frequency and nocturia, and with or without urge incontinence. Duloxetine, an antidepressant that inhibits reuptake of serotonin and norepinephrine, is indicated...
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Depression masquerading as chest pain in a patient with Wolff Parkinson White syndrome

Madabushi , Agarwal A, Tewari S, Gautam SK, Khuba S

Wolff Parkinson White (WPW) syndrome is a condition in which there is an aberrant conduction pathway between the atria and ventricles, resulting in tachycardia. A 42-year-old patient, who was treated...
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Serotonin Syndrome following Duloxetine Administration in a Fibromyalgia Patient: Case Report and Literature Review

Choi JS, Lee JH, Park SK, Shim BJ, Choi WK, Kim SH, Hwang SC

Serotonin syndrome, an adverse drug reaction, is a consequence of excess serotonergic agonism of central nervous system receptors and peripheral serotonergic receptors. Serotonin syndrome has been associated with large numbers...
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Neuroprotective Effect of Duloxetine on Chronic Cerebral Hypoperfusion-Induced Hippocampal Neuronal Damage

Park JA, Lee CH

Chronic cerebral hypoperfusion (CCH), which is associated with onset of vascular dementia, causes cognitive impairment and neuropathological alterations in the brain. In the present study, we examined the neuroprotective effect...
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Effectiveness of Duloxetine Monotherapy Compared to Combination Therapy with Other Antidepressants in Patients with Major Depressive Disorder: A Short-Term, Retrospective Study

Cheon EJ, Lee JY, Choi JH, Lee YJ, Koo BH

OBJECTIVE: The purpose of this study was to compare duloxetine monotherapy to combination therapy with other antidepressants in patients with major depressive disorder in a clinical, real world setting. METHODS: An...
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Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder

Park YM, Lee BH, Lee HJ, Kang SG

  • KMID: 2315894
  • Psychiatry Investig.
  • 2010 Sep;7(3):228-230.
Duloxetine is a balanced and potent serotonin and noradrenaline reuptake inhibitor (SNRI) and has adverse effects that are commonly associated with such drugs, including nausea, dry mouth, constipation, insomnia, and...
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The Combination of Antidepressant Duloxetine with Piracetam in Mice does not Produce Enhancement of Nootropic Activity

Kale PP, Addepalli , Sarkar A, Patel S, Savai J

There is a strong association between depression and memory impairment. The present study aims to assess the nootropic activity of duloxetine and piracetam combination. Male Swiss Albino mice were divided...
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Report of Bilateral Acute Angle-closure Crisis Induced by Serotonin-norepinephrine Reuptake Inhibitors

Yoo J, Jun RM, Choi KR, Han KE

PURPOSE: This study reports a case of bilateral acute angle-closure crisis induced by two kinds of serotonin-norepinephrine reuptake inhibitors (SNRIs), duloxetine and tramadol. CASE SUMMARY: A 55-year-old female visited our clinic,...
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Pharmacokinetics and Safety of Duloxetine Enteric-coated Tablets in Chinese Healthy Volunteers: A Randomized, Open-label, Single- and Multiple-dose Study

Li H, Li T, Li Y, Shen Y

  • KMID: 2171194
  • Clin Psychopharmacol Neurosci.
  • 2013 Apr;11(1):28-33.
OBJECTIVE: Duloxetine hydrochloride is a selective serotonin (5-hydroxytryptamine) and norepinephrine reuptake inhibitor. It is approved for effective treatment for major depressive disorder. The pharmacokinetics (PK) of duloxetine has been studied,...
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Effectiveness of Pregabalin for Treatment of Burning Mouth Syndrome

Amasyalı , Gürses AA, Aydın ON, Akyol A

Treatment of burning mouth syndrome (BMS) is challenging because there is no consensus regarding pharmalogical or nonpharmalogical therapies. The use of anticonvulsants is controversial. We present nine patients BMS who...
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Botulinum Toxin Type A Injection for Neuropathic Pain in a Patient With a Brain Tumor: A Case Report

Nam KE, Kim JS, Hong BY, Sul B, Choi H, Jun SY, Lim SH

Neuropathic pain is usually managed pharmacologically, rather than with botulinum toxin type A (BTX-A). However, medications commonly fail to relieve pain effectively or have intolerable side effects. We present the...
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Duloxetine, a Selective Noradrenaline Reuptake Inhibitor, Increased Plasma Levels of 3-Methoxy-4-hydroxyphenylglycol but Not Homovanillic Acid in Patients with Major Depressive Disorder

Atake K, Yoshimura , Hori H, Katsuki A, Ikenouchi-Sugita A, Umene-Nakano W, Nakamura J

  • KMID: 2171127
  • Clin Psychopharmacol Neurosci.
  • 2014 Apr;12(1):37-40.
OBJECTIVE: We investigated the effects of duloxetine on the plasma levels of catecholamine metabolites and serum brain-derived neurotrophic factor (BDNF) in 64 patients with major depressive disorder (MDD). METHODS: Major depressive...
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