- Effect of MK-801 on Methamphetamine - Induced Dopaminergic Neurotoxicity: Long-Term Attenuation of Methamphetamine - Induced Dopamine Release
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Kim SE, Kim YR, Hwang SH
- KMID: 1611502
- Korean J Nucl Med.
- 2001 Aug;35(4):258-267.
No abstract available. -
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- The Effect of MK801 on SSEP and Patholoy in Chronic Spinal Cord Injured Rat
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Roh SW, Kim YS, Yoon DH, Rhim SC, Kong KY, Park SH, Lee KH
- KMID: 2118477
- J Korean Neurosurg Soc.
- 2000 Sep;29(9):1153-1160.
No abstract available. -
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- Effects of MK-801, CNQX, Cycloheximide and BAPTA-AM on Anoxic Injury of Hippocampal Organotypic Slice Culture
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Moon SH, Kwon TH, Park YK, Chung HS, Suh JK
- KMID: 1547771
- J Korean Neurosurg Soc.
- 2000 Aug;29(8):1008-1018.
No abstract available. -
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- The Ototoxicity of Cisplatin is Mediated by NO: A Study using L-NAME and MK-801 in Guinea pigs
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Rhee CK, Oh YH, Jeon SJ, Chung SY, Oh CH
- KMID: 2275942
- Korean J Otolaryngol-Head Neck Surg.
- 2002 Aug;45(8):741-746.
BACKGROUND AND OBJECTIVES: Nitric oxide has been suggested to play an important role in the pathogenesis of cisplatin ototoxicity. L-NAME (NG-Nitroarginine Methyl Ester) is an inhibitor of nitric oxide synthase.... -
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- Neuroprotective Effect of Dizocilpine (MK-801) via Anti-apoptosis on Hypoxic-ischemic Brain Injury in Neonatal Rats
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Seo MA, Lee HJ, Choi EJ, Kim JK, Chung HL, Kim WT
- KMID: 2321487
- J Korean Soc Neonatol.
- 2010 Nov;17(2):181-192.
PURPOSE: Current studies have demonstrated the neuroprotective effects of dizocilpine (MK-801) in many animal models of brain injury, including hypoxic-ischemic (HI) encephlopathy, trauma and excitotoxicity, but limited data are available... -
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- Neuroprotective Effects of Dizocilpine (MK-801) Via Mediation of Nitric Oxide Synthase on Hypoxic-ischemic Brain Injury in Neonatal Rats
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Jo JY, Lee HJ, Choi EJ, Kim JK, Chung HL, Kim WT
- KMID: 2280826
- Korean J Perinatol.
- 2011 Sep;22(3):181-193.
PURPOSE: Current studies have demonstrated the neuroprotective effects of dizocilpine (MK-801) in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma and excitotoxicity, but limited data are available... -
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- Effect of MK-801 on the Prevention and Treatment of Tardive Dyskinesia
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Seo JS, Chung YC, Park KY, Eun HB, Kim YH
- KMID: 2202987
- J Korean Soc Biol Psychiatry.
- 1997 Nov;4(2):246-250.
Tardive dyskinesia(TD) is a serious side effect of long-term treatment with neuroleptic medications. To investigate if glutamatergic hyperfunction is associated with TD, effect of MK-801 on the prevention and treatment... -
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- Effects of Dizocilpine (MK-801) via Up-modulation of N-methyl-D-aspartate (NMDA) Receptors on Hypoxic-Ischemic Brain Injury in Neonatal Rats
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Kim JH, Lee HJ, Lee EJ, Choi EJ, Kim JK, Chung HL, Kim WT
- KMID: 2280991
- Korean J Perinatol.
- 2014 Sep;25(3):166-177.
- doi: 10.14734/kjp.2014.25.3.166
OBJECTIVE: Several studies have demonstrated the neuroprotective effects of (+)-MK-801 hydrogen maleate (dizocilpine), in various animal models of hypoxic-ischemic (HI) brain injury. However limited data are available on the neonatal... -
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- Effect of Antioxidant and NMDA Receptor Antagonist on Mercury-Induced Toxicity in Cultured Preimplantation Embryos
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Hong GY, Pak ST
- KMID: 2260873
- Korean J Obstet Gynecol.
- 1998 Mar;41(3):695-701.
The embryotoxicity of methylmercuric chloride[MMC] was evaluated by the calculation of cell developmental rate in order to clarify the mechanism of oxidative injury induced by MMC. 2-cell embryos derived from... -
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- Neuroprotective Effects of MK-801 (Dizocilpine) on Bilirubin Neurotoxicity in Mouse Cortical Cell Culture
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Hwang JH, Choi CW, Chang YS, Park WS
- KMID: 1609582
- Korean J Perinatol.
- 2004 Mar;15(1):34-40.
OBJECTIVE: To evaluate whether MK-801, N-methyl-D-aspartate (NMDA) receptor antagonist, could protect against bilirubin neurotoxicity in mouse neuronal cells. METHODS: Mouse cerebral cortical cells were obtained from 14 day-old mouse fetal cerebral... -
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- Mediation of N-methyl-D-aspartate on neuropeptide Y expression induced by morphine in mouse cerebellum
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Kwon GY, Kim SK
- KMID: 1607136
- Korean J Physiol Pharmacol.
- 2001 Dec;5(6):479-485.
The existence of opioid receptors in mammalian cerebellum except human, has not been clearly understood. In the present study, we found that NPY was inducible by morphine in the mouse... -
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- Excitotoxic Cell Death in Cultured Retinal Neurons
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Yoon YH, Shim MJ, Lee J
- KMID: 2123633
- J Korean Ophthalmol Soc.
- 1997 Nov;38(11):1987-1999.
We examined excitotoxicity, putatively a major mechanism of ischemic neuronal death, in primary rat retinal cultures. Retinal cultures were prepared from newborn rats (day 1 or 2). Exposure of these... -
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- The expression of the immediate early genes, c-fos, krox-24 and the late response gene, BKNF induced by antiepileptic drugs
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Suh SC, Park YC, Kim SK
- KMID: 2066085
- J Korean Neurol Assoc.
- 1997 Jun;15(3):542-554.
The expression of the c-fos and krox-24 (immediate early genes: IEGs) and the BDNF (late response gene) were investigated by convulsants such as kainate (KA, 200 micrometer), N-methyl-D-aspartate (NMDA, 10... -
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- Effect of MK801 and CNQX on Retinal Injury Induced by Ischemia, NMDA, or Kainate
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Choi JS, Gwag BJ, Yoon SK, Joo CK
- KMID: 2108525
- J Korean Ophthalmol Soc.
- 1998 Aug;39(8):1794-1800.
To examine the protection of retinal cell death by glutamate antagonists in vivo, this study was carried out in pressure-induced ischemia model. Firstly, we observed that ischemia resulted in the... -
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- The Role of the Glutamate Receptor in the Transient Focal Cerebral Ischemia in Rats
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Chae CH, Kim HK, Kim KH, Baik SW, Kim IS
- KMID: 2155260
- Korean J Anesthesiol.
- 2000 Jun;38(6):1062-1067.
- doi: 10.4097/kjae.2000.38.6.1062
BACKGROUND: To investigate the role of glutamate in the transient focal cerebral ischemia, a reversible middle cerebral artery occlusion model was induced in 25 male Sprague-Dawley rats. METHODS: Triphenyltetrazolium chloride (TTC)... -
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- Effects of MK801 on Neuronal Activity of the Contralateral Medial Vestibular Nuclei Following Unilateral Labyrinthectomy in Rats
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Kang GW, Jang CH, Lee JH, Lee MY, Kim MS, Park BR
- KMID: 2074344
- Korean J Otolaryngol-Head Neck Surg.
- 1999 Feb;42(2):139-144.
BACKGROUND AND OBJECTIVES: Several lines of evidence suggest that recovery of symptoms following unilateral labyrinthectomy (ULX) is due to the restoration of neuronal activity in the ipsilateral vestibular nuclei, leading... -
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- Comparison of neurotoxicity induced by some glutathione depletors in mouse cortical cell cultures
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Lee GW, Lee KS, Park SH, Bae CS, Kim JK
- KMID: 1580804
- Korean J Physiol Pharmacol.
- 2000 Jun;4(3):177-183.
We examined the neurotoxic effects of 3 glutathione (GSH) depletors, buthionine sulfoximine (BSO), diethyl maleate (DEM) and phorone, under the presence of trolox, cycloheximide (CHX), pyrrolidine dithiocarbamate (PDTC) or MK-801 in primary mouse... -
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- The Effect of Intrathecal NMDA and non-NMDA Receptor Antagonist on the Hyperalgesia Observed after Thermal Injury in the Rat
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Jun JH
- KMID: 2039879
- Korean J Anesthesiol.
- 1998 Apr;34(4):708-715.
- doi: 10.4097/kjae.1998.34.4.708
BACKGROUND: Previous reports have described NMDA antagonist reduced the nerve injury induced or inflammatory thermal hyperalgesia. This study evaluated the effects of spinally administered excitatory amino acid antagonists on the... -
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- (3H)MK-801 binding to the synaptic membranes of rat forebrains: Age-related regulation by glutamate, glycine and spermine
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Cho J, Kong JY
- KMID: 1554547
- Korean J Physiol Pharmacol.
- 1997 Apr;1(2):117-125.
The N-methyl-D-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission is involved in synaptic plasticity, developmental processes, learning and memory and many neuropathological disorders including age-related diseases. In the present study, regulation of the NMDA receptor properties by... -
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- Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice
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Jeon SJ, Kim B, Ryu B, Kim E, Lee S, Jang DS, Ryu JH
- KMID: 2378802
- Biomol Ther.
- 2017 May;25(3):249-258.
- doi: 10.4062/biomolther.2016.058
To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time... -
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