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Understanding Disease Susceptibility through Population Genomics

Han S, Lee J, Kim S

Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression...
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Gender Difference in Mediating Effects of Self-Efficacy for the Prevention of Sexually Transmitted Diseases (STD) among College Students' STD Knowledge, Susceptibility, and Sexual Autonomy

Park M

PURPOSE: The purpose of the study was to examine the impact of self-efficacy in the prevention of sexually transmitted diseases (STD), knowledge of and susceptibility to STD, and the role...
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Nutrition, Epigenetics, and Diseases

Jang H, Serra C

Increasing epidemiological evidence suggests that maternal nutrition and environmental exposure early in development play an important role in susceptibility to disease in later life. In addition, these disease outcomes seem...
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Discriminant analysis of prion sequences for prediction of susceptibility

Lee JH, Bae SE, Jung S, Ahn I, Son HS

  • KMID: 2154267
  • Exp Mol Med.
  • 2013 Oct;45(10):e48.
Prion diseases, including ovine scrapie, bovine spongiform encephalopathy (BSE), human kuru and Creutzfeldt-Jakob disease (CJD), originate from a conformational change of the normal cellular prion protein (PrPC) into abnormal protease-resistant...
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Analysis of the markers related with relapse after withdrawal of antithyroid drug in patients with Graves' disease

Kim KW, Park YJ, Lee YJ, Lee EJ, Lee EK, Park MH, Park DJ, Cho BY

  • KMID: 2256414
  • Korean J Med.
  • 2007 May;72(5):522-528.
BACKGROUND: Graves' disease is an organ-specific autoimmune disease that is characterized by thyrotoxicosis, and this is caused by TSH receptor stimulating autoantibody. Antithyroid drugs have been a mainstay of treatment...
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Correlation between GenoType MTBDRplus Assay and Phenotypic Susceptibility Test for Prothionamide in Patients with Genotypic Isoniazid Resistance

Lee JH, Jo KW, Shim TS

BACKGROUND: The purpose of this study was to analyze the relationship between the gene mutation patterns by the GenoType MTBDRplus (MTBDRplus) assay and the phenotypic drug susceptibility test (pDST) results...
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Susceptibility of some vertebrate hosts to infection with early third-stage larvae of Gnathostoma hispidum

Sohn WM, Lee SH

Susceptibility of some vertebrates was examined to the early third-stage larvae (EL3) of Gnathostoma hispidum. The larvae collected from the Chinese loaches were infected to 4 silk carps,...
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Sunburn Deteriorated to a Deep Second-Degree Wound in a Healthy Young Female without Risk Factors

Yoon HS, Na YC

Sunburn is the transient inflammatory response of skin caused by excessive exposure to ultraviolet radiation (UVR). The rate of disease progression varies because each individual has different levels of sunburn...
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Association of HLA Class II and Non-HLA Gene Polymorphisms with Disease Susceptibility in Korean Children with Type 1 Diabetes Mellitus

Jung MH, Suh BK, Kim TG, Shin CH, Lee BC

  • KMID: 1568739
  • J Korean Soc Pediatr Endocrinol.
  • 2004 Dec;9(2):136-144.
Purpose : The main genetic contribution to type 1 diabetes susceptibility is the human leukocyte antigen (HLA) class II gene. Several non-HLA chromosomal regions are also known to be involved....
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Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer

Lee HC, Yoon YB, Kim CY

  • KMID: 1051581
  • Korean J Intern Med.
  • 1997 Jun;12(2):128-136.
OBJECTIVES: Metabolic activation is a prerequisite for the carcinogenic effect of many carcinogens, and considerable interindividual variation exists in the metabolic capacity to activate the carcinogens. The cytochromes P-450 (CYPs)...
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Diabetes-Related Cardiac Dysfunction

Williams L, Nye BG, Wende AR

The proposal that diabetes plays a role in the development of heart failure is supported by the increased risk associated with this disease, even after correcting for all other known...
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Familial systemic lupus erythematosus in two Korean male siblings

Kang HS, Oh HJ, Kim YR, Kim JW, Shin KS

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of a wide range of autoantibodies, resulting in tissue damage. Although the susceptibility to SLE has been...
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Pathogenesis of Ankylosing Spondylitis

Hur JW, Kim TH

  • KMID: 2334810
  • J Korean Rheum Assoc.
  • 2005 Sep;12(3):163-172.
The hallmark of ankylosing spondylitis (AS) is acute and chronic spinal inflammation initiating in the sacroiliac joints, often coupled with enthesitis, presenting as chronic inflammation at the sites of ligamentous...
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Prevalence of ICA and anti-GAD, HLA DRB1 / DQA1 / DQB1 Polymorphism in Korean IDDM Patients

Park YS, Shin JH, Kim JB, Choi WH, Ahn YH, Kim TW, Kim MH, Yang SW, Hwang SD, Rhee HB

  • KMID: 2137374
  • J Korean Diabetes Assoc.
  • 1997 Sep;21(3):289-299.
BACKGROUND: Although the HLA class II genes are cleaily associated with insulin-dependent diabetes mellitus(IDDM) in all ethnic. Groups, considerable variation in the associated genotypes is observed among the different ethnic...
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HLA and Disease Associations in Koreans

Ahn S, Choi HB, Kim TG

The human leukocyte antigen (HLA), the major histocompatibility complex (MHC) in humans has been known to reside on chromosome 6 and encodes cell-surface antigen-presenting proteins and many other proteins related...
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Apolipoprotein E (APOE) Polymorphisms and Susceptibility to Breast Cancer: A Meta-Analysis

Saadat M

  • KMID: 2167597
  • Cancer Res Treat.
  • 2012 Jun;44(2):121-126.
PURPOSE: Apolipoprotein E (APOE, MIM: 107741) has three functionally distinct isoforms of the protein (E2, E3, and E4), encoded by corresponding alleles epsilon2, epsilon3, and epsilon4, which have been well...
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Association between Lung Cancer Susceptibility Variants Identified by Genome-Wide Association Studies and the Survival of Non-Small Cell Lung Cancer

Hong MJ, Choi YY, Do SK, Jeon HS, Yoo SS, Lee WK, Lee SY, Lee J, Cha SI, Kim CH, Lee E, Park JY

PURPOSE: Nowadays, chromosomal regions containing genes associated with the risk of lung cancer are identified by a number of genome-wide association studies (GWASs). As part of the study, GWAS has...
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The Factors Related to Musculoskeletal Symptoms of Male Taxi Drivers

Eum MJ, Jung HS

PURPOSE: This study was conducted to understand the subjective symptom rate of musculoskeletal disease of male taxi drivers and comprehend general features, health behavior features, and factors related to the...
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Copy Number Variations in the Human Genome: Potential Source for Individual Diversity and Disease Association Studies

Kim TM, Yim SH, Chung YJ

  • KMID: 2166314
  • Genomics Inform.
  • 2008 Mar;6(1):1-7.
The widespread presence of large-scale genomic variations, termed copy number variation (CNVs), has been recently recognized in phenotypically normal individuals. Judging by the growing number of reports on CNVs, it...
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Immunosuppressive effect of Cryptosporidium baileyi infection on vaccination against avian infectious bronchitis in chicks

Rhee JK, Yang HJ, Yook SY, Kim HC

Two-day-old commercial chicks were inoculated orally with 2 x 10(6) oocysts of Cryptosporidium baileyi and vaccinated with 10(3.5) EID50/head of a commercially available avian infectious bronchitis (IB) live virus vaccine...
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