- Lack of multi-organ carcinogenesis in female N:GP(S) mice by benzo(a) pyrene, dimethylnitrosamine and dibutylnitrosamine
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Lee YS, Cho KJ, Jang JJ
- KMID: 1742249
- J Korean Cancer Assoc.
- 1993 Aug;25(4):572-577.
No abstract available. -
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- Morphologic Change of Rat Liver Induced by Repeated Administration of Carbon Tetrachloride and Dimethylnitrosamine
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Lee TS
- KMID: 2373920
- Yeungnam Univ J Med.
- 1987 Aug;4(1):89-96.
- doi: 10.12701/yujm.1987.4.1.89
Carbon tetrachloride and dimethylnitrosamine, both potent hepatotoxic agents, affect the hepatic lobules with fatty changes and central necrosis, and hemorrhagic necrosis. To study the effects on morphologic changes of the... -
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- Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters
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Lee JH, Rim HJ, Bak UB
- KMID: 1715491
- Korean J Parasitol.
- 1993 Mar;31(1):21-30.
- doi: 10.3347/kjp.1993.31.1.21
The study was carried out to observe the effects of Clonorchis sinensis infection on induction of cholangiocarcinoma in Syrian golden hamsters to which 15 ppm dimethylnitrosamine (DMN) solution was administered... -
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- Immunohistochemical Reaction of Hepatic Stellate Cells in Dimethylnitrosamine-induced Rat Liver Damage
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Son HI, Lee CH, Suh KS
- KMID: 1548545
- Korean J Gastroenterol.
- 1999 Oct;34(4):479-488.
BACKGROUND/AIMS: Hepatic stellate cell (HSC) is the major source of extracellular matrix in the liver. The purpose of this study was to evaluate the pattern of immunocytochemical expression in HSC... -
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- Promoting role of Clonorchis sinensis infection on induction of cholangiocarcinoma during two-step carcinogenesis
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Lee JH, Yang HM, Bak UB, Rim HJ
- KMID: 1715452
- Korean J Parasitol.
- 1994 Mar;32(1):13-18.
- doi: 10.3347/kjp.1994.32.1.13
Chronic Clonorchis sinensis (CS) infection is etiologically related to cholangiocarcinoma (CHCA) in human and animals. This study was carried out to clarify the role of CS infection on dimethylnitrosamine (DMN)-induced... -
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- Protective Effect of Pentoxifylline and Ciprofloxacin on Dimethylnitrosamine-induced Hepatic Fibrosis in Rats
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Suh KS, Lee CH, Sol MY, Lee SK
- KMID: 2241262
- Korean J Hepatol.
- 2001 Mar;7(1):34-46.
BACKGROUND/AIMS: Hepatic fibrosis is known to be a predisposing condition of cirrhosis for which there is no proven effective therapy. The aim of this study was to investigate the effect... -
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- Cellular Distribution of TGF-beta1 Peptide in Dimethylnitrosamine Induced Fibrosis of Rat Liver
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Lee SN, Park DY, Lee SK
- KMID: 2037292
- Korean J Pathol.
- 1997 Nov;31(11):1157-1165.
Recently attention has been focused on the biology of transforming growth factor-beta1 (TGF-beta1). TGF-beta1, a potent regulator of cell proliferation, stimulates the proliferation of many cell types of mesenchymal origin... -
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- Effects of Excretory/Secretory Products from Clonorchis sinensis and the Carcinogen Dimethylnitrosamine on the Proliferation and Cell Cycle Modulation of Human Epithelial HEK293T Cells
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Kim EM, Kim JS, Choi MH, Hong ST, Bae YM
- KMID: 1720554
- Korean J Parasitol.
- 2008 Sep;46(3):127-132.
- doi: 10.3347/kjp.2008.46.3.127
Clonorchis sinensis is one of the most prevalent parasitic helminths in Korea. Although cholangiocarcinoma can be induced by C. sinensis infection, the underlying mechanism is not clearly understood. To assess... -
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- Effects of carbon tetrachloride on structures in hepatocytes following DMN induced hepatotoxicity
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Kang YC, Nam HJ, Kim DS, Choi WH, Lee TS
- KMID: 2377363
- Yeungnam Univ J Med.
- 1991 Dec;8(2):84-94.
- doi: 10.12701/yujm.1991.8.2.84
The purpose of this study was to evaluate the influence of high dose carbon tetrachloride (CCI4) on the hepatotoxic effect of dimethylnitrosamine (DMN) which induces acute hemorrhagic necrosis in liver.... -
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- Issues on carcinogen contaminated antihypertensive drugs and constructing drug safety management system
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Park BJ
- KMID: 2442732
- J Korean Med Assoc.
- 2019 Apr;62(4):182-185.
- doi: 10.5124/jkma.2019.62.4.182
European Medicines Agency withdrew valsartan from European market in July 2018 because it was contaminated with carcinogen, N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA). Medicines and Healthcare Products Regulatory Agency also found... -
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- Effect of dietary supplementation of grape skin and seeds on liver fibrosis induced by dimethylnitrosamine in rats
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Shin MO, Moon JO
- KMID: 2313468
- Nutr Res Pract.
- 2010 Oct;4(5):369-374.
Grape is one of the most popular and widely cultivated fruits in the world. Although grape skin and seeds are waste product of the winery and grape juice industry, these... -
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- Evaluation of Liver Function Using 99mTc-Lactosylated Serum Albumin Liver Scintigraphy in Rat with Acute Hepatic Injury Induced by Dimethylnitrosamine
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Jeong SY, Lee J, Seo M, Yoo JA, Bae JH, Ahn BC, Hwang JS, Jeong JM, Ha JH, Lee KB
- KMID: 1516877
- Korean J Nucl Med.
- 2003 Dec;37(6):418-427.
OBJECTS: 99mTc-lactosylated human serum albumin (LSA) is a newly synthesized radiopharmaceutical that binds to asialoglycoprotein receptors, which are specifically presented on the hepatocyte membrane. Hepatic uptake and blood clearance of... -
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- Cell cycle protein profile of the hepatic stellate cells (HSCs) in dimethylnitrosamine-induced rat hepatic fibrosis
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Kim MR, Kim HS, Lee MS, Lee MJ, Jang JJ
- KMID: 1093468
- Exp Mol Med.
- 2005 Aug;37(4):335-342.
Cell cycle regulating proteins are known to have close relation with the proliferation of the mammalian cells. In injured liver, the number of HSCs is increased from proliferation. However, the... -
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- Gene therapy via adenovirus vector carrying matrix metalloproteinase-3 (MMP-3) in a rat model of liver cirrhosis
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Kim SY, Her WH, Ryu JS, Wang JS, Bae SH, Jang JW, Kim CW, Dong MS, Yoon SK
- KMID: 2256495
- Korean J Med.
- 2006 Dec;71(6):609-619.
BACKGROUND: Liver cirrhosis is characterized by fibrous scarring and hepatocellular regeneration. Matrix metalloproteinases (MMPs) comprise a family of zinc-dependent enzymes that degrade the extracellular matrix (ECM) components. This study examined... -
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- Ingestion Exposure to Nitrosamines in Chlorinated Drinking Water
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Kim H, Han K
- KMID: 2380153
- Environ Health Toxicol.
- 2011 ;26(1):e2011003.
OBJECTIVES: N-Nitrosodimethylamine (NDMA) is classified as a probable human carcinogen by the United States Environmental Protection Agency (US EPA) and is formed during the chlorination of municipal drinking water. In... -
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- Suppressive Effects of Antioxidant DA-9601 on Hepatic Fibrosis in Rats
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Cheong JY, Oh TY, Lee KM, Kim DH, Ahn BO, Kim WB, Kim YB, Yoo BM, Hahm KB, Kim JH, Cho SW
- KMID: 863119
- Korean J Hepatol.
- 2002 Dec;8(4):436-447.
BACKGROUND/AIMS: Oxidative stress is one of the important underlying mechanisms of hepatic fibrosis. DA-9601, the ethanol extracts of Artemisia asiatica, has been reported to possess strong antioxidative and cytoprotective... -
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- C3H/He Mice as an Incompatible Cholangiocarcinoma Model by Clonorchis sinensis, Dicyclanil and N-Nitrosodimethylamine
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Uddin MH, Li S, Jin Y, Choi MH, Jang JJ, Hong ST
- KMID: 2348269
- Korean J Parasitol.
- 2016 Jun;54(3):281-289.
- doi: 10.3347/kjp.2016.54.3.281
Clonorchis sinensis is a Group-I bio-carcinogen, associated with cholangiocarcinoma (CCA). The hamster is the only experimental model of C. sinensis-mediated CCA, but we oblige another animal model. The present study... -
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- Development of Urinary Bladder Pre-Neoplasia by Schistosoma haematobium Eggs and Chemical Carcinogen in Mice
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Chala B, Choi MH, Moon KC, Kim HS, Kwak C, Hong ST
- KMID: 2374799
- Korean J Parasitol.
- 2017 Feb;55(1):21-29.
- doi: 10.3347/kjp.2017.55.1.21
Schistosoma haematobium is a biocarcinogen of human urinary bladder (UB). The present study investigated developing UB cancer mouse model by injecting S. haematobium eggs into the bladder wall and introduction... -
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- Genetic Polymorphism of Cytochrome P450 2E1 in Hepatocellular Carcinoma Patients in Korea
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Paik SW, Yoon JH, Hwang YJ, Jang YH, Lee HS, Kim CY
- KMID: 2084763
- Korean J Gastroenterol.
- 1997 Oct;30(4):503-512.
Background/Airns: Cytochrome P450 2E1 (CYP2EI) is the only enzyme that rnetabolizes very low doses of N-nitrosodimethylamine (NDMA) and is characterized by its ethanol inducibility. Recently, it has been shown in... -
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- Lectin Histochemistry for Effects of N - Nitrosodimethylamine on Glycoconjugates in the Rat Lingual Salivary Glands
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Jo UB, Choi YJ, Jo GJ, Park SM
- KMID: 2283102
- Korean J Phys Anthropol.
- 1998 Dec;11(2):281-297.
The effect of NDMA after oral administration (17 mg/ml) on the glycoconjugates of lingual von Ebner's gland and mucous gland were investigated with lectin histochemical methods. For lectin histochemical studies,... -
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