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The Effect of Diclofenac Sodium on Uncontrolled Postoperative Back Pain by IV-PCA

Lee J, Kim HY, Kim WS, Choe H

BACKGROUND: Although postoperative back pain has been reported to occur, as a frequent complication of anesthesia and surgery, it is usually mild and self-limited. However, we experienced cases of uncontrolled...
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Pharmacoknetic Study of Diclofenac and Its Interaction with Enrofloxacin in Buffalo Calves

Kumar N, Singh SD, Jayachandran C

  • KMID: 1089406
  • J Vet Sci.
  • 2003 Aug;4(2):155-159.
A comparative pharmacokinetic study of diclofenac (1 mg/kg, i.v.) when given alone or in combination with enrofloxacin (4 mg/kg, i.v.) in five buffalo calves was carried out by using HPLC....
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A Case of Nicolau Syndrome Due to Diclofenac Sodium

Kim SJ, Kang JD, Yoon NH, Park SD

  • KMID: 2302934
  • Korean J Dermatol.
  • 2004 Mar;42(3):370-372.
Nicolau syndrome is defined as local cutaneous and sometimes muscular necrosis observed at the injection site of intramuscular preparations. It is characterized by severe pain immediately after the injection and...
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Two cases of anaphylaxis to diclofenac with aspirin tolerance

Lee JY, Byun YH, Cho YB, Lee BH, Ahn Y, Kim SH

  • KMID: 1984652
  • Korean J Med.
  • 2005 Jul;69(1):113-116.
Anaphylaxis is an acute life-threatening reaction, usually mediated by immunologic and non- immunologic mechanisms. Non-steroidal anti-inflammatory drugs (NSAIDs) can produce anaphylactic reactions by different pathogenic mechanisms. The most of these...
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Nicolau Syndrome following Diclofenac Injection in an Emergency Department

Chung S, Kang J, Yeo J, Ko J

  • KMID: 2101643
  • J Korean Soc Clin Toxicol.
  • 2011 Dec;9(2):101-104.
Nicolau syndrome is a rare adverse reaction at the site of an intramuscular injection, and is characterized by severe pain immediately after the injection and rapid development of distinct skin...
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The Analgesic and Hemostatic Effects of Diclofenac as Adjuvant of Intravenous Opioid Using PCA after Cesarean Section

Kim CJ, Chea JS, Chung MY, Lee BH, Yoon JW

BACKGROUND: Diclofenac is a nonsteroidal anti-inflammatory drug widely used as adjuvant for postoperative pain management using intravenous Patient Controlled Analgesia (PCA). The analgesic and hemostatic effects of diclofenac were measured...
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Comparison of Diclofenac or Fentanyl for Pain Following Tonsillectomy

Kang WJ, Shin OY, Kwon MI, Choi YK, Yoo JW, Cho JS

BACKGROUND: This study was designed to compare intramuscular diclofenac with intravenous fentanyl in the prevention of pain after tonsillectomy and adenoidectomy for day-surgery. METHODS: We studied 60 patients, aged 3-13 years,...
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A Case of Nicolau Syndrome Treated by Surgical Excision

Ku BS, Lee YK, Kwon OE, Lee CW, Kim KH

  • KMID: 2248914
  • Korean J Dermatol.
  • 2006 Dec;44(12):1464-1466.
Nicolau syndrome or embolia cutis medicamentosa is an acute necrotic condition of skin that follows intramuscular injection of drugs. A 36-year-old man developed a painful, purpuric and erythematous patch on...
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Nicolau Syndrome in Patient Following Diclofenac Administration: A Case Report

Kim KK

  • KMID: 2383253
  • Ann Dermatol.
  • 2011 Nov;23(4):501-503.
Nicolau syndrome is a rare adverse reaction to a variety of intra-muscular drug preparations. The typical presentation is pain around the injection site soon after injection, followed by erythema, livedoid...
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Effect of Dexamethasone and Diclofenac on the Proliferation of Human Corneal Keratocytes

Lee JE, Lee SU, Kim JH, Lee JS

  • KMID: 2207589
  • J Korean Ophthalmol Soc.
  • 2005 Jan;46(1):133-143.
PURPOSE: To evaluate the inhibitory effect of dexamethasone and diclofenac on the proliferation of cultured human keratocytes, and to investigate the apoptotic response and the cellular morphologic changes associated with...
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A Case of Diclofenac-Induced Anaphylaxis with Elevated Serum Tryptase

  • KMID: 2299672
  • Korean J Asthma Allergy Clin Immunol.
  • 2005 Sep;25(3):228-230.
Diclofenac is a non-steroid anti-inflammatory drug (NSAID), which belongs to the phenylacetic acid group. It is commonly used in inflammatory conditions of various etiologies, degenerative joint disease, rheumatoid arthritis and...
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Diclofenac Inhibits 27-hydroxycholesterol-induced Differentiation of Monocytic Cells into Mature Dendritic Cells

Son Y, Kim BY, Park YC, Kim K

We investigated whether diclofenac could influence the development of antigen-presenting cells in an oxygenated cholesterol-rich environment by determining its effects on the 27-hydroxycholesterol (27OHChol)-induced differentiation of monocytic cells into mature...
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Efficacy of Topical NSAIDs and Anesthetic Drug in Reducing Post-PRK Pain: Comparative Study

Lim HT, Kim YK, Tchah HW

  • KMID: 2336737
  • J Korean Ophthalmol Soc.
  • 1999 Jan;40(1):61-69.
To evaluate the efficacy and safety of topical NSAIDs and topical anesthetics on post-PRK pain control, we performed a prospective, randomized, paralle group, placebe-controlled study of 105 consecutive eyes having...
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The Toxic Effects of Diclofenac Sodium on Cultured Rabbit Corneal Epithelium

Son WS, Hyun JK

  • KMID: 2123985
  • J Korean Ophthalmol Soc.
  • 1998 Jun;39(6):1087-1094.
Diclofenac sodium is a widely used drug for reducing inflammation and pain after cataract, surgery or excirner laser photorefractive keratectomy. However,we could find epithelial defect while using this drug postoperatively....
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A Study about the Cause and Clinicopathologic Findings of Injection-Induced Dermatitis

Oh YJ, Lew BL, Sim WY

BACKGROUND: Cases of dermatitis induced by the injection of certain drugs have been reported. OBJECTIVE: The aim of this study was to assess the cause and clinicopathologic findings of injection-induced dermatitis,...
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Embolia Cutis Medicamentosa Following Intramuscular Injection of Diclofenac

Go JW, Kim SH, Ro BI, Oh HE, Cho HK

  • KMID: 2088082
  • Korean J Dermatol.
  • 2010 Sep;48(9):786-789.
Nicolau syndrome or embolia cutis medicamentosa is a rare complication of a still largely unidentified pathogenesis at the site of intramuscular injections of various drugs. It is characterized by development...
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Morphine and Meperidine Analgesic Effect Using Intravenous PCA of Intramuscular Diclofenac after Cesarean Section

Lee BH, Lim YG, Chea JS, Kim CJ, Chung MY, Jung JY

BACKGROUND: Diclofenac is a nonsteroidal anti-inflammatory drug widely used as adjuvants for postoperative pain management with opioid sparing effect. The effect of diclofenac on postoperative opioid analgesia of morphine and...
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The Effects of Topical Anesthetics used in Phacoemulsification

Kwon JW, Tchah H

  • KMID: 2336941
  • J Korean Ophthalmol Soc.
  • 2000 Jul;41(7):1539-1543.
A total of 80 cases undergone the routine phacoemulsification and the posterior chamber lens implantation under various topical anesthetics have been studied. The patients were divided into four groups from...
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Comparison of safety and analgesic efficacy of diclofenac sodium with etodolac after surgical extraction of third molars: a randomized, double-blind, double-dummy, parallel-group study

Vaghela JH, Shah JH, Patel JH, Purohit BM

BACKGROUND: Surgical extraction of third molars is associated with postoperative pain and swelling at the extraction site. Pain is commonly managed using non-steroidal anti-inflammatory drugs (NSAIDs). Postoperative pain is usually...
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Nicolau Syndrome after Intramuscular Injection: 3 Cases

Kim SK, Kim TH, Lee KC

Nicolau syndrome is a rare complication of intramuscular injection consisting of ischemic necrosis of skin, soft tissue, and muscular tissue that arises locoregionally. The characteristic pattern is pain around the...
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